WormBase Tree Display for Gene: WBGene00002982

WBGene00002982 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: B0336
  Identity: Version: 2
    Name: CGC_name: lgg-3 Person_evidence: WBPerson321
      Sequence_name: B0336.8
      Molecular_name: B0336.8
        B0336.8.1
        CE00776
      Other_name (2)
      Public_name: lgg-3
    DB_info: Database: AceView gene 3G786
        WormQTL gene WBGene00002982
        WormFlux gene WBGene00002982
        NDB locus_tag CELE_B0336.8
        Panther gene CAEEL|WormBase=WBGene00002982|UniProtKB=Q10931
          family PTHR13385
        NCBI gene 175793
        RefSeq protein NM_065827.3
        SwissProt UniProtAcc Q10931
        TREEFAM TREEFAM_ID TF325131
        UniProt_GCRP UniProtAcc Q10931
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 15 Mar 2007 08:30:58 WBPerson2970 Name_change: Other_name: atg-12
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lgg
    Allele: WBVar00250621
      WBVar01500260
      WBVar01500122
      WBVar01500123
      WBVar00829183
      WBVar00829184
      WBVar00829185
      WBVar00275641
      WBVar02053280
    RNASeq_FPKM (74)
    GO_annotation (16)
    Contained_in_operon: CEOP3324
    Ortholog (34)
    Structured_description: Concise_description: lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. Paper_evidence: WBPaper00004403
            WBPaper00005654
            WBPaper00013631
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Involved in cellular response to toxic substance; determination of adult lifespan; and xenophagy. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Is an ortholog of human ATG12 (autophagy related 12). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: B0336.8
    Corresponding_transcript: B0336.8.1
    Associated_feature: WBsf651070
      WBsf655435
  Experimental_info: RNAi_result (34)
    Expr_pattern: Expr1014494
      Expr1031382
      Expr1143130
      Expr2013144
      Expr2031376
    Drives_construct: WBCnstr00036307
    Construct_product: WBCnstr00036307
    Antibody: WBAntibody00002571
    Microarray_results (16)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032097:CGH-1-associated-mRNA
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00038118:aak-2(gt33)_downregulated
      WBPaper00040560:hpl-2_embryo_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045316:prg-1_upregulated_L1
      WBPaper00045521:Oogenic
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00048926:miaserin_upregulated_adult-day5
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051461:pig-1(gm344)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00054626:NO_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056293:rpl-5(0)-rpl-33(0)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:pch-2-B0393.3
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00063930:BRD-1_interacting
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_9
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_F
      WBPaper00037147:heatshock_upregulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:oogenesis-enriched
    Interaction (26)
  Map_info: Map: III Position: -1.45276 Error: 0.000601
    Positive: Positive_clone: B0336 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (17)
  Remark: Sequence connection from [Kimura Y]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene