WormBase Tree Display for Gene: WBGene00002055

WBGene00002055 SMap: S_parent: Sequence: F37B4
  Identity: Version: 1
    Name: CGC_name: ifc-1 Person_evidence: WBPerson105
            WBPerson293
      Sequence_name: F37B4.2
      Molecular_name (3)
      Other_name: Cel IF C1 Accession_evidence: EMBL X70832
        CelIF c1
        CELE_F37B4.2 Accession_evidence: NDB BX284605
      Public_name: ifc-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ifc
    Allele (60)
    Strain: WBStrain00032410
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (49)
    Paralog (12)
    Structured_description: Concise_description: ifc-1 encodes a nonessential intermediate filament protein; IFC-1 is predicted to function as a structural component of the cytoskeleton; IFC-1 has no function in RNAi assays. Paper_evidence: WBPaper00001981
            WBPaper00004761
            WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cellular localization; heterochromatin formation; and nucleus organization. Predicted to be located in nuclear envelope and nuclear lamina. Expressed in hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; ichthyosis (multiple); and palmoplantar keratosis (multiple). Is an ortholog of several human genes including KRT1 (keratin 1); KRT2 (keratin 2); and KRT3 (keratin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (14)
  Molecular_info: Corresponding_CDS: F37B4.2
    Corresponding_transcript: F37B4.2.1
    Other_sequence: CJC06704_1
      CBC04609_1
      CBC08053_1
      CBC01028_1
    Associated_feature: WBsf661170
      WBsf231539
      WBsf231540
      WBsf231541
  Experimental_info: RNAi_result: WBRNAi00007220 Inferred_automatically: RNAi_primary
      WBRNAi00014485 Inferred_automatically: RNAi_primary
      WBRNAi00046594 Inferred_automatically: RNAi_primary
      WBRNAi00097123 Inferred_automatically: RNAi_primary
      WBRNAi00062649 Inferred_automatically: RNAi_primary
      WBRNAi00062650 Inferred_automatically: RNAi_primary
      WBRNAi00098345 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3398
      Expr15263
      Expr1025855
      Expr1031208
      Expr1150478
      Expr2012681
      Expr2030917
    Drives_construct: WBCnstr00011377
      WBCnstr00036489
      WBCnstr00042144
    Construct_product: WBCnstr00011377
      WBCnstr00036489
      WBCnstr00042144
    Antibody: WBAntibody00000796
    Microarray_results (17)
    Expression_cluster: WBPaper00028451:Abundant_spermatogenesis_enriched
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:insoluble_protein
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00041071:spe-44_upregulated
      WBPaper00043945:MeHg_downregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044260:nicotinc-acid_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045401:N.parisii_8h_upregulated
      WBPaper00045401:N.parisii_40h_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049290:rsks-1(sv31)_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049954:BPA_downregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050096:P.aeruginosa_downregulated
      WBPaper00050163:let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050163:let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050193:dpy-27(RNAi)_downregulated_L1
      WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1
      WBPaper00050225:flp-6(RNAi)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050504:hrp-2(RNAi)_downregulated
      WBPaper00050561:indole_10-fold_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051137:N.parisii-virus_upregulated_N2
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056039:hda-6(ok3203)_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056586:kri-1(ok1251)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059334:sacy-1(depletion)_regulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059426:Ag-nanoparticles_downregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059604:fluvastatin_upregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_upregulated_N2
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_downregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060764:swsn-1(os22ts)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060951:mrpl-2(osa3)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061081:E.faecalis_downregulated_skpo-1(ok1640)
      WBPaper00061081:skpo-1(ok1640)_downregulated_OG1RF
      WBPaper00061106:endu-2(tm4977)_upregulated
      WBPaper00061319:pnp-1(jy90)_upregulated
      WBPaper00061319:pnp-1(jy121)_upregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:mup-2-unc-87_284
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061590:CGP37157_downregulated
      WBPaper00061818:ELKS-1_interacting
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062167:mbl-1(tm1563)_downregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062293:clk-1(qm30)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)_upregulated
      WBPaper00063976:micu-1(bon20)_upregulated
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064532:pals-22(jy3)_upregulated
      WBPaper00064624:iHg-induced_aggregome
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064789:Day9_vs_Day1_upregulated_neuron
      WBPaper00064871:PA14-gacA()_downregulated_AWA
      WBPaper00064871:PA14_downregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064952:Day5_vs_L4_downregulated_25C
      WBPaper00064952:Day10_vs_L4_downregulated_20C
      WBPaper00065086:N2_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4386_cluster_1_6
      cgc4489_group_24
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026980:intestine_enriched
      WBPaper00028789:PA14_vs_OP50_downregulated_4hr
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00029437:rde-4_upregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00032948:StarveUp2
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040876:mir-35_downregulated
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041207:CE_dauer_down
      WBPaper00041211:RPW-24_Down
      WBPaper00041267:SpaceFlight_Downregulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_downregulated_YoungAdult
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00044013:nasp-1_upregulated
      WBPaper00044091:Bpseudomallei_repressed_2h
      WBPaper00044091:Bpseudomallei_repressed_4h
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00049311:AgNO3_regulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053688:E.faecium_downregulated
      WBPaper00055435:MUA-AuNP-3_downregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc6390]:Cluster_A
    Interaction (77)
  Map_info: Map: V Position: -12.8753 Error: 0.001266
    Positive: Positive_clone: F37B4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (13)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene