WormBase Tree Display for Gene: WBGene00002005

WBGene00002005 SMap: S_parent: Sequence: F26D10
  Identity: Version: 1
    Name: CGC_name: hsp-1 Person_evidence: WBPerson36
      Sequence_name: F26D10.3
      Molecular_name: F26D10.3
        F26D10.3.1
        CE09682
      Other_name (2)
      Public_name: hsp-1
    DB_info: Database: AceView gene 4S223
        WormQTL gene WBGene00002005
        WormFlux gene WBGene00002005
        NDB locus_tag CELE_F26D10.3
        Panther gene CAEEL|WormBase=WBGene00002005|UniProtKB=P09446
          family PTHR19375
        NCBI gene 178507
        RefSeq protein NM_070667.7
        SwissProt UniProtAcc P09446
        UniProt_GCRP UniProtAcc P09446
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hsp
    Allele (70)
    Legacy_information: [C.elegansII] NMK. Encodes protein related to generic hsp70. Quite strong expression normally, only weak heat shock induction. [Heschl and Baillie 1990; BC]
    Strain: WBStrain00037793
      WBStrain00005873
      WBStrain00005874
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (90)
    Paralog (12)
    Structured_description: Concise_description: hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. Paper_evidence: WBPaper00001048
            WBPaper00001320
            WBPaper00006377
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables ATP hydrolysis activity. Involved in determination of adult lifespan; response to heat; and retrograde transport, endosome to Golgi. Located in cytosol and nucleus. Expressed in germ line and intestine. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); brain disease (multiple); and eye disease (multiple). Is an ortholog of human HSPA8 (heat shock protein family A (Hsp70) member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (35)
  Molecular_info: Corresponding_CDS: F26D10.3
    Corresponding_transcript: F26D10.3.1
    Other_sequence (757)
    Associated_feature (19)
  Experimental_info: RNAi_result (52)
    Expr_pattern: Expr563
      Expr5873
      Expr14424
      Expr1014885
      Expr1031170
      Expr1149522
      Expr2012623
      Expr2030859
    Drives_construct: WBCnstr00002042
      WBCnstr00036527
      WBCnstr00040854
    Construct_product: WBCnstr00016264
      WBCnstr00036527
    Antibody: WBAntibody00002793
    Microarray_results (28)
    Expression_cluster: WBPaper00006047:15C_temperature_specific
      WBPaper00024704:Soluble_protein
      WBPaper00026640:Development_Group_I
      WBPaper00031011:calmodulin_binding_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00031674:feh-1(gb561)(RNAi)_upregulated
      WBPaper00032031:DConiospora_upregulated_cDNA_12h
      WBPaper00032528:L3_enriched
      WBPaper00033208:STI-1_interacting
      WBPaper00034755:ALG-1_interacting
      WBPaper00035567:CHN-1_interacting
      WBPaper00035963:S.aureus_24h_downregulated
      WBPaper00036291:ung-1_regulated
      WBPaper00036662:oxidative_modification
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037109:cyclophilin-inhibitor_regulated
      WBPaper00037615:hypoxia_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038061:aldicarb_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038357:atx-3_regulated_heat-shock
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040446:insoluble_protein
      WBPaper00040755:LRRK2(G2019S)-Tau_vs_Tau_upregulated
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00041097:pgl-1_downregulated
      WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq
      WBPaper00042477:RSR-2_complex
      WBPaper00042552:daf-2(e1370)_downregulated_daf-16-dependent
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00043951:Nascent-polypeptide-associated
      WBPaper00044128:daf-2(e1370)_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044616:alg-3-4_downregulated_gene
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045460:pept-1(lg601)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045729:gld-4(RNAi)_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046981:daf-2(e1370)_downregulated_lipid-droplet
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049482:P.mirabilis_48h_regulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049626:UNC-75_target
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050199:hsf-1(ok600)_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050636:aging_regulated_insoluble_protein
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053254:hsp-90(RNAi)_upregulated_protein
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00054189:P.aeruginosa_regulated_protein
      WBPaper00054996:activated_sperm_CE
      WBPaper00054996:membranous_oraganelle_CE
      WBPaper00055013:HMG-3_interacting_transcript
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055897:heat-shock_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056501:P.aeruginosa_downregulated_mitochondria-protein
      WBPaper00056673:Gamma-Irradiation_regulated
      WBPaper00056826:SGP_biased
      WBPaper00056868:P.aeruginosa_downregulated_smallRNA
      WBPaper00056900:ERH-2_interacting
      WBPaper00056900:PID-3_interacting
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056900:TOST-1_interacting
      WBPaper00056997:nmad-1(ok3133)_downregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059194:KLF-1_interacting
      WBPaper00059254:CSR-1_interacting
      WBPaper00059254:PRG-1_interacting
      WBPaper00059254:WAGO-1_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060908:TEBP-1_interacting
      WBPaper00060908:TEBP-2_interacting
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061285:wounding_0h_downregulated
      WBPaper00061285:wounding_24h_downregulated
      WBPaper00061340:ASE_parent
      WBPaper00061340:ASI_parent
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061340:Neuroblast_URX_CEPDx
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061393:C.albicans_regulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:dld-1-skn-1_16701
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:Germline_enriched
      WBPaper00061651:I4_enriched
      WBPaper00061651:PDE_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061651:VB_enriched
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00062002:Day4-adult_secretome
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00063976:micu-1(bon20)_downregulated
      WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064201:SNA-1_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064257:UNG-1_interacting
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F2
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_2_3
      cgc4489_group_3
      cgc4489_group_24
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_A
      WBPaper00026980:intestine_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_7
      WBPaper00032948:FedUp
      WBPaper00036286:Pattern_E
      WBPaper00039835:ifg-1_downregulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040821:Au-NP_regulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_39
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(66_min)
      [cgc5767]:expression_class_ME
      [cgc6390]:intrinsic
    Interaction (414)
    WBProcess: WBbiopr:00000039
  Map_info: Map: IV Position: 16.3526 Error: 0.011292
    Well_ordered
    Positive: Positive_clone: F26D10 Inferred_automatically: From sequence, transcript, pseudogene data
        HSL151
    Mapping_data: 2_point: 4670
        4674
      Multi_point: 1124
        4164
        4677
        5557
      Pos_neg_data: 4675
    Landmark_gene
  Reference (62)
  Method: Gene