WormBase Tree Display for Gene: WBGene00001502

WBGene00001502 SMap: S_parent: Sequence: F52D10
  Identity: Version: 1
    Name: CGC_name: ftt-2 Person_evidence: WBPerson577
      Sequence_name: F52D10.3
      Molecular_name: F52D10.3a
        F52D10.3a.1
        CE03389
        F52D10.3c
        CE51934
        F52D10.3c.1
      Other_name: CELE_F52D10.3 Accession_evidence: NDB BX284606
      Public_name: ftt-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ftt
    Allele (31)
    Legacy_information: [Iino Y] predicted gene product has sequence similarity to the 14-3-3 family of proteins.
    Strain: WBStrain00027454
      WBStrain00055539
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (52)
    Paralog: WBGene00003920 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00010919 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ftt-2 encodes a 14-3-3 protein; FTT-2 is required for regulating the localization of the product of YAP-1, a Yes-associated protein (Yap) homolog, between the cytoplasm and the nucleus. Paper_evidence (2)
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 Mar 2013 00:00:00
      Automated_description: Enables DNA-binding transcription factor binding activity. Involved in cytoplasmic sequestering of protein; dauer larval development; and negative regulation of protein import into nucleus. Located in cytoplasm and nucleus. Expressed in several structures, including C; E; Psub3; gonad; and intestine. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ovarian cancer; and urinary bladder cancer. Is an ortholog of human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:8719 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
      DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
      DOID:2671 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12855)
      DOID:2101 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10773)
  Molecular_info: Corresponding_CDS: F52D10.3a
      F52D10.3c
    Corresponding_CDS_history: F52D10.3b:wp121
      F52D10.3b:wp271
    Corresponding_transcript: F52D10.3a.1
      F52D10.3c.1
    Other_sequence (379)
    Associated_feature (22)
  Experimental_info: RNAi_result (65)
    Expr_pattern: Expr677
      Expr678
      Expr3992
      Expr4515
      Expr14505
      Expr1014656
      Expr1030902
      Expr1151782
      Expr2011916
      Expr2030153
    Drives_construct: WBCnstr00009103
      WBCnstr00012073
      WBCnstr00036906
    Construct_product: WBCnstr00009103
      WBCnstr00012073
      WBCnstr00036906
    Antibody: WBAntibody00001182
    Microarray_results (31)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035963:S.aureus_24h_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_Day10
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048988:neuron_expressed
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050199:hsf-1(ok600)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050514:CEBP-1_interacting
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_nucleus_expressed
      WBPaper00051538:micro-gavity_downregulated_protein
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053615:SMO-1_target
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056900:PID-3_interacting
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056900:TOST-1_interacting
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059194:KLF-1_interacting
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059334:SACY-1_interacting
      WBPaper00059440:GLP-1_represseded
      WBPaper00059440:LAG-1_activated_4hr-auxin
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060908:TEBP-1_interacting
      WBPaper00061340:AIB
      WBPaper00061340:AVB
      WBPaper00061340:AVE
      WBPaper00061340:AVK
      WBPaper00061340:PVP
      WBPaper00061340:PVT
      WBPaper00061340:RIM
      WBPaper00061340:SIA
      WBPaper00061340:SIB
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061405:S.aureus_downregulated_starvation
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:tars-1-AFFX-r2-3026-5_at
      WBPaper00061527:unc-44_403-H24G06.1_2859
      WBPaper00061651:AIM_enriched
      WBPaper00061651:AVD_enriched
      WBPaper00061651:AVG_enriched
      WBPaper00061651:DA_enriched
      WBPaper00061651:DB01_enriched
      WBPaper00061651:DB_enriched
      WBPaper00061651:HSN_enriched
      WBPaper00061651:I4_enriched
      WBPaper00061651:NSM_enriched
      WBPaper00061651:PDB_enriched
      WBPaper00061651:PLM_enriched
      WBPaper00061651:PLN_enriched
      WBPaper00061651:PVC_enriched
      WBPaper00061651:PVM_enriched
      WBPaper00061651:PVR_enriched
      WBPaper00061651:PVW_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:RIG_enriched
      WBPaper00061651:Spermatheca_enriched
      WBPaper00061651:VA12_enriched
      WBPaper00061651:VA_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061651:VB_enriched
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065158:AFD_depleted
      WBPaper00065373:Cisplatin_downregulated_WT
      cgc4386_cluster_5_3
      WBPaper00025032:PAL-1_target_genes
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_A_Class
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00030985:Serratia_marcesens_upregulated
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035892:Y.pestis_regulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00038427:lin-54_germline_changed
      WBPaper00039835:ifg-1_upregulated
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(101_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_C
      [cgc6390]:male_soma-enriched
    Interaction (399)
    WBProcess: WBbiopr:00000025
  Map_info: Map: X Position: 4.88794 Error: 0.044755
    Positive: Positive_clone: F52D10 Person_evidence: WBPerson284
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5040
    Pseudo_map_position
  Reference (37)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene