| WBGene00001165 | SMap | S_parent | Sequence | F56A11 |
|---|
| Identity (6) |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | efn |
| | Allele (170) |
| | Legacy_information | [C.elegansII] bx80sd : fusions among all rays; also head, body and (especially) tail deformities; bx80/+ impenetrant R4 to R3 transformation. [Chow and Emmons 1994; EM] |
| | Strain | WBStrain00005372 |
| | | WBStrain00007176 |
| | | WBStrain00049265 |
| | | WBStrain00049276 |
| | RNASeq_FPKM (74) |
| | GO_annotation (33) |
| | Ortholog (50) |
| | Paralog | WBGene00001163 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001164 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006869 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | efn-4 encodes a divergent member of the ephrin family of ligands; efn-4 is required for neuroblast migrations during closure of the ventral gastrulation cleft and subsequent epidermal morphogenesis, possibly functioning independently of EFN-1, EFN-2, EFN-3, and the VAB-1 receptor during morphogenesis; EFN-4 can interact weakly with VAB-1 in vitro; EFN-4 is expressed in neural and epidermal precursors at the 100-cell stage, in head neurons, pharyngeal cells, lateral and tail neurons, and in the ectoderm during epidermal enclosure. | Paper_evidence | WBPaper00003865 |
| | | | | | WBPaper00005631 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | Date_last_updated | 23 Jul 2008 00:00:00 |
| | | Automated_description | Predicted to enable ephrin receptor binding activity. Involved in several processes, including embryonic morphogenesis; nematode male tail tip morphogenesis; and regulation of axon guidance. Located in axon and neuronal cell body. Expressed in several structures, including CAN; epithelial cell; ganglia; intestinal cell; and somatic nervous system. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome; dysostosis; and stomach cancer. Is an ortholog of human EFNB1 (ephrin B1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:1934 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3226) |
| | | DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3226) |
| | | DOID:14737 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3226) |
| Molecular_info | Corresponding_CDS | F56A11.3 |
| | Corresponding_transcript | F56A11.3.1 |
| | Other_sequence | CR11929 |
| | | TS00903 |
| | | TSC03402_1 |
| | | CRC05251_1 |
| | | CBC06448_1 |
| | | CR02130 |
| | Associated_feature (22) |
| Experimental_info | RNAi_result | WBRNAi00111800 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00067312 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086136 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00067361 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00064650 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00048574 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00015760 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00000722 |
| | | WBCnstr00000723 |
| | | WBCnstr00006419 |
| | | WBCnstr00011024 |
| | | WBCnstr00037053 |
| | | WBCnstr00042431 |
| | | WBCnstr00042437 |
| | Construct_product | WBCnstr00006419 |
| | | WBCnstr00021468 |
| | | WBCnstr00021469 |
| | | WBCnstr00021470 |
| | | WBCnstr00021472 |
| | | WBCnstr00021473 |
| | | WBCnstr00021477 |
| | | WBCnstr00022268 |
| | | WBCnstr00037053 |
| | Antibody | WBAntibody00000596 |
| | Microarray_results (21) |
| | Expression_cluster | WBPaper00032031:DConiospora_downregulated_cDNA_12h |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00044037:eat-2_downregulated |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:NMDA-neuron_enriched |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060764:swsn-1(os22ts)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061340:ADF_AWB |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:AMso_parent |
| | | WBPaper00061340:ASG_AWA |
| | | WBPaper00061340:ASK_parent |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:B |
| | | WBPaper00061340:F_U |
| | | WBPaper00061340:g2_parent |
| | | WBPaper00061340:I1_parent |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061340:Neuroblast_ASE_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_AVG_RIR |
| | | WBPaper00061340:Parent_of_K_Kprime |
| | | WBPaper00061340:pm6 |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RMED |
| | | WBPaper00061340:Y |
| | | WBPaper00061527:cids-2_2203-attf-2_2451 |
| | | WBPaper00061527:skr-16-F37B4.10 |
| | | WBPaper00061530:nhr-49(e2144)_upregulated |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062193:daf-16(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_transcript |
| | | WBPaper00062456:doxycycline_downregulated_N2_transcript |
| | | WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065841:17_0 |
| | | WBPaper00065841:49_0 |
| | | WBPaper00065841:61_0 |
| | | WBPaper00065841:66_0 |
| | | WBPaper00065841:68_0 |
| | | WBPaper00065841:68_1 |
| | | WBPaper00065841:92_0 |
| | | WBPaper00065841:95_0 |
| | | WBPaper00065841:96_0 |
| | | WBPaper00065841:98_0 |
| | | WBPaper00065841:105_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:117_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:123_0 |
| | | WBPaper00065841:131_0 |
| | | WBPaper00065841:139_0 |
| | | WBPaper00065841:140_0 |
| | | WBPaper00065841:145_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | cgc4489_group_5 |
| | | WBPaper00025032:cluster_39 |
| | | WBPaper00025032:cluster_79 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Erwinia_carotovora_downregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(143_min) |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SET |
| | | [cgc5767]:expression_class_SE_pi(83_min) |
| | | [cgc6390]:Cluster_A |
| | Interaction (63) |
| | WBProcess | WBbiopr:00000025 |
| Map_info | Map | IV | Position | -25.7615 | Error | 0.138637 |
| | Positive | Positive_clone | F56A11 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 3132 |
| | | | 4992 |
| | | | 5641 |
| Reference (44) |
| Method | Gene |
