WormBase Tree Display for Gene: WBGene00001099

WBGene00001099 Evidence: Paper_evidence: WBPaper00006232
      WBPaper00005018
  SMap: S_parent: Sequence: K02D7
  Identity: Version: 1
    Name: CGC_name: dsc-4 Person_evidence: WBPerson247
      Sequence_name: K02D7.4
      Molecular_name: K02D7.4
        K02D7.4.1
        CE33667
      Other_name: CELE_K02D7.4 Accession_evidence: NDB BX284604
      Public_name: dsc-4
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dsc
    Allele (60)
    Strain: WBStrain00026671
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (35)
    Structured_description: Concise_description: dsc-4 encodes the C. elegans ortholog of the large subunit of the microsomal triglyceride transfer protein; dsc-4 affects the length of the defecation cycle and genetically interacts with clk-1 with respect to defecation cycle length, and also with respect to the clk-1- dependent adjustment of defecation cycle length to temperature; a DSC-4::GFP fusion protein is expressed in the intestine beginning during embryonic elongation and continuing on through adulthood. Paper_evidence: WBPaper00005018
            WBPaper00006232
          Curator_confirmed (2)
          Date_last_updated: 15 Dec 2006 00:00:00
      Automated_description: Predicted to enable lipid transfer activity and phospholipid transporter activity. Involved in lipoprotein transport and plasma lipoprotein particle assembly. Located in endoplasmic reticulum. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including abetalipoproteinemia; familial hypercholesterolemia; and hyperinsulinism. Is an ortholog of human MTTP (microsomal triglyceride transfer protein). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9452 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7467)
      DOID:13810 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7467)
      DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7467)
      DOID:0080208 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7467)
      DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7467)
      DOID:2018 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7467)
      DOID:1386 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7467)
  Molecular_info: Corresponding_CDS: K02D7.4
    Corresponding_CDS_history: K02D7.4:wp97
    Corresponding_transcript: K02D7.4.1
    Other_sequence (20)
    Associated_feature: WBsf651615
      WBsf995119
      WBsf229671
  Experimental_info: RNAi_result: WBRNAi00090628 Inferred_automatically: RNAi_primary
      WBRNAi00025848 Inferred_automatically: RNAi_primary
      WBRNAi00085937 Inferred_automatically: RNAi_primary
      WBRNAi00085914 Inferred_automatically: RNAi_primary
      WBRNAi00049699 Inferred_automatically: RNAi_primary
      WBRNAi00016449 Inferred_automatically: RNAi_primary
      WBRNAi00027397 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2799
      Expr1022313
      Expr1030700
      Expr1153419
      Expr2011102
      Expr2029338
    Drives_construct: WBCnstr00010952
      WBCnstr00037083
    Construct_product: WBCnstr00010952
      WBCnstr00037083
    Microarray_results (18)
    Expression_cluster: WBPaper00005432:xbp-1(zc12)_downregulated
      WBPaper00031040:Cluster_1
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032031:DConiospora_downregulated_cDNA_24h
      WBPaper00032528:L3_enriched
      WBPaper00035073:mitochondria_protein
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044128:daf-2(e1370)_upregulated
      WBPaper00044316:HgCl2_7.5uM_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046121:endoderm_unique
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00047132:skn-1(RNAi)_downregulated
      WBPaper00048926:miaserin_upregulated_adult-day5
      WBPaper00048952:glucose_repressed
      WBPaper00048988:neuron_expressed
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049484:elt-2(RNAi)_downregulated_L4
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPA_upregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050121:mir-60(n4947)_downregulated
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050442:P.aeruginosa_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051039:intestine_enriched
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051461:pig-1(gm344)_downregulated
      WBPaper00051558:aging_regulated
      WBPaper00053094:adr-2(ok735)_neuron_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058678:DAF-12_downregulated_PVD
      WBPaper00059373:stt-3(RNAi)_upregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059895:wounding_downregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_1h_regulated
      WBPaper00060871:M.humicola-extract_4h_regulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:C18B2.5-haf-4_181
      WBPaper00061818:ELKS-1_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064130:Beta-Amyloid_upregulated_protein
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064871:hypoxia_upregulated_F3
      WBPaper00064952:Day10_vs_L4_downregulated_25C
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:3_0
      WBPaper00065841:3_1
      WBPaper00065841:3_2
      WBPaper00065841:3_4
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_2_3
      cgc4489_group_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026952:class_A
      WBPaper00026980:intestine_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031850:mdt-15(RNAi)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_C
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00039851:HK_C_albicans_vs_HK_OP50
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2down
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041211:RPW-24_Up
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00044535:male_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00047070:DAF-16-dependent_UV_response
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00049311:AgNO3_regulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053550:daf-19(m86)_downregulated_AdultDay2
      WBPaper00053688:E.faecalis_downregulated
      WBPaper00053688:E.faecium_downregulated
      [cgc6390]:Cluster_C
    Interaction (59)
    WBProcess: WBbiopr:00000121
  Map_info: Map: IV Position: -26.6463 Error: 0.02418
    Positive: Positive_clone: K02D7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 7143
      Multi_point: 4691
        5537
  Reference: WBPaper00005018
    WBPaper00005432
    WBPaper00006232
    WBPaper00018895
    WBPaper00026830
    WBPaper00033099
    WBPaper00042349
    WBPaper00053100
    WBPaper00061228
    WBPaper00065331
  Remark: dsc-4 complements flr-3(ut9) Person_evidence: WBPerson3095
  Method: Gene