WormBase Tree Display for Gene: WBGene00000975

WBGene00000975 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 1
    Name: CGC_name: dhs-12 Person_evidence: WBPerson651
      Sequence_name: K08F4.9
      Molecular_name: K08F4.9
        K08F4.9.1
        CE06157
        K08F4.9.2
        K08F4.9.3
      Other_name: CELE_K08F4.9 Accession_evidence: NDB BX284604
      Public_name: dhs-12
    DB_info: Database: AceView gene 4K911
        WormQTL gene WBGene00000975
        WormFlux gene WBGene00000975
        NDB locus_tag CELE_K08F4.9
        Panther gene CAEEL|WormBase=WBGene00000975|UniProtKB=G5EG13
          family PTHR43544
        NCBI gene 177888
        RefSeq protein NM_069449.8
        TREEFAM TREEFAM_ID TF314888
        TrEMBL UniProtAcc G5EG13
        UniProt_GCRP UniProtAcc G5EG13
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dhs
    Allele (52)
    RNASeq_FPKM (74)
    GO_annotation (2)
    Ortholog (80)
    Paralog (22)
    Structured_description: Concise_description: dhs-12 encodes a predicted short-chain dehydrogenase. Curator_confirmed: WBPerson1843
          Date_last_updated: 04 Jan 2013 00:00:00
      Automated_description: Predicted to enable oxidoreductase activity. Predicted to be located in cytoplasm. Is an ortholog of human CBR1 (carbonyl reductase 1) and CBR3 (carbonyl reductase 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K08F4.9
    Corresponding_transcript: K08F4.9.1
      K08F4.9.2
      K08F4.9.3
    Other_sequence: CBC04851_1
      MIC08702_1
      CJC00884_1
      CBC08415_1
      CRC00438_1
      MH00376
      MHC00816_1
    Associated_feature: WBsf228940
  Experimental_info: RNAi_result (27)
    Expr_pattern: Expr1018106
      Expr1030608
      Expr1154028
      Expr2010895
      Expr2029134
    Drives_construct: WBCnstr00037166
    Construct_product: WBCnstr00037166
    Microarray_results (31)
    Expression_cluster: WBPaper00026640:Development_Group_I
      WBPaper00027339:daf-12(rh273)_downregulated
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040560:hpl-2_embryo_downregulated
      WBPaper00044128:daf-2(e1370)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049732:blmp-1(tm548)_vs_N2_downregulated
      WBPaper00050225:flp-6(RNAi)_downregulated
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:downregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_nucleus_expressed
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:AVJ
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:F45H10.2-R53.4_21676
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated_germline
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062293:isp-1(qm150)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064163:ZNFX-1_interacting_young-adult
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065841:5_0
      WBPaper00065841:5_1
      WBPaper00065841:21_0
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066085:hda-3(ok1991)_downregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066085:sin-3(tm1276)_downregulated
      cgc4489_group_2
      cgc4489_group_8
      WBPaper00005124:cholesterol_10-9M_regulated
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00025032:cluster_3
      WBPaper00025099:NI_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_E
      WBPaper00026980:intestine_enriched
      WBPaper00028789:PA14_vs_OP50_downregulated_4hr
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031184:acrylamide_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp2
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036464:S.aureus-RN6390_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00039866:ClassComp_daf-19_downregulated
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041906:I-3690_vs_OP50_10d
      WBPaper00041906:I-4317_vs_OP50_10d
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00043980:arsenic_upregulated
      WBPaper00044013:nasp-1_upregulated
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00047021:MWCNT_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00049311:Ag-MNP_regulated
      WBPaper00051387:Triclosan_downregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
      WBPaper00053688:E.faecalis_upregulated
      WBPaper00053688:E.faecium_upregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:cluster_8
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc5976]:class_1
      [cgc6390]:male_sex-enriched
    Interaction (103)
  Map_info: Map: IV Position: 4.54171 Error: 0.001128
    Positive: Positive_clone: K08F4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00026640
    WBPaper00041771
    WBPaper00042257
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene