| WBGene00000523 | Evidence | Person_evidence | WBPerson765 |
|---|
| SMap | S_parent | Sequence | C01C10 |
| Identity (6) |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | clc |
| | Allele (46) |
| | Strain | WBStrain00032009 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00003803 |
| | | 00003804 |
| | | 00057138 |
| | | 00057139 |
| | | 00057140 |
| | | 00057141 |
| | | 00057142 |
| | | 00107533 |
| | Contained_in_operon | CEOPX088 |
| | Ortholog (27) |
| | Paralog | WBGene00000522 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00000526 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | WBGene00013458 |
| | | WBGene00011014 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | WBGene00016067 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | WBGene00010742 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | WBGene00016706 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00021415 | Caenorhabditis elegans | From_analysis | Panther |
| | Structured_description | Concise_description | clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes; clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein. | Paper_evidence | WBPaper00004961 |
| | | | | | WBPaper00005946 |
| | | | | | WBPaper00005975 |
| | | | | | WBPaper00012856 |
| | | | | | WBPaper00018356 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Involved in epithelial cell-cell adhesion. Located in plasma membrane. Expressed in hypodermis and seam cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C01C10.1a |
| | | C01C10.1b |
| | Corresponding_transcript | C01C10.1a.1 |
| | | C01C10.1b.1 |
| | Other_sequence | NAC00990_1 |
| | | BU666339.1 |
| | | Dviv_isotig23650 |
| | | GR12997 |
| | | GRC02095_1 |
| | | CBC17674_1 |
| | Associated_feature (7) |
| Experimental_info | RNAi_result | WBRNAi00009908 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00088425 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077666 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077665 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00039290 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1207 |
| | | Expr1208 |
| | | Expr2560 |
| | | Expr1014543 |
| | | Expr1030312 |
| | | Expr1143408 |
| | | Expr2010042 |
| | | Expr2028283 |
| | Drives_construct | WBCnstr00010853 |
| | | WBCnstr00037476 |
| | Construct_product | WBCnstr00010853 |
| | | WBCnstr00037476 |
| | Antibody | WBAntibody00000650 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040560:hpl-2_embryo_upregulated |
| | | WBPaper00042561:smg-2(RNAi)_downregulated |
| | | WBPaper00042561:smgl-1(RNAi)_downregulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched |
| | | WBPaper00048690:male-Z1-Z4-daughter_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049489:AMsh-glia_enriched |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_downregulated |
| | | WBPaper00049920:hyl-2(tm2031)_upregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050743:elli-1(sam-3)_downregulated |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053402:cco-1(RNAi)_upregulated |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060526:plp-1(ok2155)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:let-418(n3536)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AMsh |
| | | WBPaper00061340:CEPsh |
| | | WBPaper00061340:CEPso |
| | | WBPaper00061340:F_U |
| | | WBPaper00061340:G2_and_W_blasts |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:hyp3 |
| | | WBPaper00061340:ILsh_OLLsh_OLQsh |
| | | WBPaper00061340:Neuroblast_HSN_PHB |
| | | WBPaper00061479:hda-1(ne4748)_upregulated |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:lon-8-C18D11.1_11630 |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_uninfected |
| | | WBPaper00065841:5_0 |
| | | WBPaper00065841:5_1 |
| | | WBPaper00065841:21_0 |
| | | WBPaper00065841:37_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066085:sin-3(tm1276)_upregulated |
| | | cgc4489_group_14 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030985:Enterococcus_faecalis_downregulated |
| | | WBPaper00030985:Erwinia_carotovora_upregulated |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00034661:AgNPs_upregulated |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00038172:aak-2overexpression_down_regulated |
| | | WBPaper00038172:crh-1null_up_regulated |
| | | WBPaper00038172:tax-6null_up_regulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041960:daf-16_fasting_upregulated |
| | | WBPaper00041960:kgb-1_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00047070:xpa-1_UV_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053827:pyoverdine_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction | WBInteraction000126407 |
| | | WBInteraction000126827 |
| | | WBInteraction000140913 |
| | | WBInteraction000140914 |
| | | WBInteraction000147230 |
| | | WBInteraction000190786 |
| Map_info | Map | X | Position | -1.73343 | Error | 0.007289 |
| | Positive | Positive_clone | C01C10 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4948 |
| | | | 4679 |
| | | | 5066 |
| | Pseudo_map_position |
| Reference | WBPaper00005946 |
| | WBPaper00018356 |
| | WBPaper00039831 |
| | WBPaper00043459 |
| | WBPaper00044402 |
| | WBPaper00044723 |
| Remark | Sequence connection from [Asano A, Tsukita S] |
| | Name exchange requested by Dr. Asano: clc-2 = C01C10.1 and clc-4 = T05A10.2 | Person_evidence | WBPerson765 |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
