WormBase Tree Display for Gene: WBGene00000371

WBGene00000371 Evidence: Paper_evidence: WBPaper00005707
  SMap: S_parent: Sequence: F26E4
  Identity: Version: 2
    Name: CGC_name: cox-5B Person_evidence: WBPerson117
            WBPerson7169
      Sequence_name: F26E4.9
      Molecular_name (4)
      Other_name: lpd-4 CGC_data_submission
        cco-1 Person_evidence: WBPerson1157
        CELE_F26E4.9 Accession_evidence: NDB BX284601
      Public_name: cox-5B
    DB_info: Database: AceView gene 1K365
        WormQTL gene WBGene00000371
        WormFlux gene WBGene00000371
        NDB locus_tag CELE_F26E4.9
        Panther gene CAEEL|WormBase=WBGene00000371|UniProtKB=P90849
          family PTHR10122
        NCBI gene 172832
        RefSeq protein NM_060200.7
        TREEFAM TREEFAM_ID TF105063
        TrEMBL UniProtAcc P90849
        UniProt_GCRP UniProtAcc P90849
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 05 Sep 2017 13:25:30 WBPerson2970 Name_change: CGC_name: cox-5B
                Other_name: cco-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cox
    Allele (21)
    Component_of_genotype: WBGenotype00000141
    RNASeq_FPKM (74)
    GO_annotation: 00049238
      00049239
      00049240
      00049241
      00049242
      00049243
      00107246
      00107247
      00107248
    Contained_in_operon: CEOP1930
    Ortholog (38)
    Structured_description: Concise_description: cox-5b encodes the ortholog of the nuclear-encoded cytochrome c oxidase-1 subunit Vb/COX4, a component of the electron transport chain in mitochondria; knock-down of cox-5b via RNA interference in specific tissues like body wall muscle decreases life span, whereas knock-down in the nervous system and intestine increases life-span; the effects of cox-5b on life span indicate that the electron transport chain functions in a tissue-specific manner to affect the aging process, and studies show that this effect is dependent on the mitochondrial unfolded protein response. Paper_evidence: WBPaper00037991
          Curator_confirmed: WBPerson324
          Date_last_updated: 04 May 2011 00:00:00
      Automated_description: Predicted to enable metal ion binding activity. Involved in determination of adult lifespan; lipid storage; and proton motive force-driven mitochondrial ATP synthesis. Predicted to be located in mitochondrial envelope. Predicted to be part of mitochondrial respiratory chain complex IV. Is an ortholog of human COX5B (cytochrome c oxidase subunit 5B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Modifies_disease: DOID:450
  Modifies_disease_in_annotation: WBDOannot00001305
  Molecular_info: Corresponding_CDS: F26E4.9
    Corresponding_transcript: F26E4.9.1
      F26E4.9.2
    Other_sequence (85)
    Associated_feature: WBsf643631
      WBsf981084
      WBsf984809
      WBsf984810
      WBsf218348
      WBsf218349
      WBsf218350
      WBsf218351
      WBsf218352
  Experimental_info: RNAi_result (135)
    Expr_pattern: Expr1011393
      Expr1030199
      Expr1149560
      Expr2009764
      Expr2028004
    Drives_construct: WBCnstr00037591
    Construct_product: WBCnstr00020784
      WBCnstr00020785
      WBCnstr00037591
    Regulate_expr_cluster (15)
    Microarray_results (26)
    Expression_cluster: WBPaper00028451:Abundant_spermatogenesis_enriched
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044128:DietaryRestriction_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00050412:cco-1(RNAi)_downregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056501:P.aeruginosa_upregulated_mitochondria-protein
      WBPaper00056900:PID-3_interacting
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061340:RIC
      WBPaper00061340:RIS
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:F45H10.2-R53.4_21676
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:Distal_tip_cell_enriched
      WBPaper00061651:Gonadal_sheath_cell_enriched
      WBPaper00061651:RME_LR_enriched
      WBPaper00062193:hsf-1(RNAi)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00064005:starvation_downregulated_N2_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064201:SNA-3_interacting
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064992:Capsaicin_upregulated
      WBPaper00064992:Eugenol_upregulated
      WBPaper00064992:heat-shock_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065373:Cisplatin_downregulated_WT
      cgc4386_cluster_1_3
      cgc4489_group_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_7
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (119)
    WBProcess: WBbiopr:00000001
      WBbiopr:00000121
  Map_info: Map: I Position: 3.90842 Error: 0.000958
    Positive: Positive_clone: F26E4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (41)
  Remark: This gene was formerly known as lpd-4 and was renamed following advice from the CGC. [krb 030512]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene