| WBGene00000266 | SMap | S_parent | Sequence | C53B4 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | bre-1 | Person_evidence | WBPerson26 |
| | | Sequence_name | C53B4.7 |
| | | Molecular_name (15) |
| | | Other_name (2) |
| | | Public_name | bre-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 15 Dec 2006 14:54:17 | WBPerson1847 | Event | Acquires_merge | WBGene00008276 |
| | | | | | | Name_change | Other_name | gmd-1 |
| | | Acquires_merge | WBGene00008276 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | bre |
| | Allele (43) |
| | Legacy_information | [Marroquin LD, Aroian RV ] Weakly resistant to Bt toxin, Cry5B |
| | Strain | WBStrain00001304 |
| | | WBStrain00008570 |
| | RNASeq_FPKM (74) |
| | GO_annotation (23) |
| | Ortholog (45) |
| | Paralog (13) |
| | Structured_description | Concise_description | bre-1 encodes one of two C. elegans GDP-mannose 4, 6-dehydratases; BRE-1 exhibits GDP-mannose dehydratase activity when expressed in vitro and thus, is predicted to function in vivo in the first step of the biosynthetic pathway that synthesizes GDP-fucose from GDP-mannose; bre-1 is required for toxicity to Cry5B, a Bacillus thurigensis delta-endotoxin, as mutant animals are defective for production of fucosylated glycolipids that act as a receptor for Cry5B; bre-1 mutant animals are also resistant to a fungal toxin Coprinopsis cinerea CGL2; bre-1 mutant animals demonstrate lack of fucosylated N- and O-glycans; bre-1 is expressed in larval and adult stages. | Paper_evidence | WBPaper00004264 |
| | | | | | WBPaper00027362 |
| | | | | | WBPaper00028852 |
| | | | | | WBPaper00035585 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 09 Apr 2010 00:00:00 |
| | | Automated_description | Enables GDP-mannose 4,6-dehydratase activity. Involved in GDP-L-fucose biosynthetic process; GDP-mannose metabolic process; and response to toxic substance. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Human ortholog(s) of this gene implicated in open-angle glaucoma. Is an ortholog of human GMDS (GDP-mannose 4,6-dehydratase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:1067 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4369) |
| Molecular_info | Corresponding_CDS | C53B4.7a |
| | | C53B4.7b |
| | | C53B4.7c |
| | | C53B4.7d |
| | | C53B4.7e |
| | Corresponding_CDS_history | C53B4.7:wp47 |
| | Corresponding_transcript | C53B4.7a.1 |
| | | C53B4.7b.1 |
| | | C53B4.7c.1 |
| | | C53B4.7d.1 |
| | | C53B4.7e.1 |
| | Other_sequence (75) |
| | Associated_feature | WBsf646202 |
| | | WBsf646203 |
| | | WBsf646204 |
| | | WBsf646205 |
| | | WBsf659838 |
| | | WBsf997329 |
| | | WBsf997330 |
| | | WBsf1017907 |
| | | WBsf228775 |
| Experimental_info | RNAi_result (11) |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00002197 |
| | | WBCnstr00037617 |
| | Construct_product | WBCnstr00013991 |
| | | WBCnstr00037617 |
| | Microarray_results (44) |
| | Expression_cluster | WBPaper00005432:xbp-1(zc12)_downregulated |
| | | WBPaper00027339:daf-12(rh273)_downregulated |
| | | WBPaper00029359_1217 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1353 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1548 |
| | | WBPaper00029359_1604 |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032031:DConiospora_upregulated_cDNA_24h |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00033070:Rhine_downregulated |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_CoreEnriched |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:intestine_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00040134:nhr-49(RNAi)_regulated_protein |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(gk119)_upregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045420:fertilization_upregulated_transcript |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050121:mir-60(n4947)_downregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050163:let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050442:P.aeruginosa_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051305:vit-2(ac3)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:spermatheca_expressed |
| | | WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1 |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4 |
| | | WBPaper00056586:kri-1(ok1251)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056855:his-72(uge40)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057162:meg-3_meg-4_downregulated_sRNA |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_protein |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059373:stt-3(RNAi)_upregulated |
| | | WBPaper00059440:GLP-1_represseded |
| | | WBPaper00059440:LAG-1_repressed_48hr-auxin |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059604:fluvastatin_downregulated_N2 |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00059754:P.aeruginosa_PA14_upregulated |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061274:hypergravity_15xg_downregulated |
| | | WBPaper00061340:g1A |
| | | WBPaper00061340:g1A_g1P |
| | | WBPaper00061340:g1P |
| | | WBPaper00061340:IL2 |
| | | WBPaper00061340:Seam_cell |
| | | WBPaper00061466:nath-10(icb99)_downregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:F54D5.3_7003-F54D5.3_7004 |
| | | WBPaper00061651:Excretory_gland_cell_enriched |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00061853:tunicamycin_downregulated_N2 |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064494:postdauer_upregulated_AWA |
| | | WBPaper00064532:pals-25(icb98)_downregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064728:cpl-1(W32AY35A)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2 |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:41_0 |
| | | WBPaper00065841:41_1 |
| | | WBPaper00065841:41_2 |
| | | WBPaper00065841:89_0 |
| | | WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066085:hda-3(ok1991)_upregulated |
| | | WBPaper00066110:Doxorubicin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4489_group_8 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027342:alpha-Synuclein(WT)_upregulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034757:down_by_oxidative_stress |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00037113:Diazinon_16C_regulated |
| | | WBPaper00037695:LD_3-day |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040998:nhr-66_regulated |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041211:RPW-24_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | [cgc6390]:Cluster_A |
| | | [cgc6390]:mixed_spermatogenesis-somatic |
| | Interaction | WBInteraction000038986 |
| | | WBInteraction000547585 |
| | | WBInteraction000551697 |
| | | WBInteraction000574221 |
| | | WBInteraction000574582 |
| | | WBInteraction000578560 |
| | | WBInteraction000582903 |
| | | WBInteraction000584992 |
| Map_info | Map | IV | Position | 4.00022 | Error | 0.000243 |
| | Positive | Positive_clone | C53B4 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 7118 |
| Reference (24) |
| Remark | Data extracted from Marroquin et al. (2000) |
| Method | Gene |
