WormBase Tree Display for Gene: WBGene00000221

WBGene00000221 SMap: S_parent: Sequence: T04C10
  Identity: Version: 3
    Name: CGC_name: atf-4
      Sequence_name: T04C10.4
      Molecular_name: T04C10.4
        T04C10.4.1
        CE06355
      Other_name: atf-5
        CELE_T04C10.4 Accession_evidence: NDB BX284606
      Public_name: atf-4
    DB_info: Database: AceView gene XP428
        WormQTL gene WBGene00000221
        WormFlux gene WBGene00000221
        NDB locus_tag CELE_T04C10.4
        Panther gene CAEEL|WormBase=WBGene00000221|UniProtKB=Q22156
          family PTHR13044
        NCBI gene 181576
        RefSeq protein NM_001420580.1
        SwissProt UniProtAcc Q22156
        TREEFAM TREEFAM_ID TF318507
        UniProt_GCRP UniProtAcc Q22156
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303075
        3 15 Jul 2019 14:29:07 WBPerson1983 Name_change: CGC_name: atf-4
                Other_name: atf-5
      Split_into: WBGene00303075
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: atf
    Allele (54)
    Strain: WBStrain00031503
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (24)
    Paralog: WBGene00012330 Caenorhabditis elegans From_analysis: Panther
      WBGene00007932 Caenorhabditis elegans From_analysis: Panther
      WBGene00013878 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00077761 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: atf-5 encodes a homolog of the mammalian bZIP transcription factors ATF4and ATF5, analogous to GCN4 in S. cerevisiae; like like ATF4 and GCN4,atf-5 has an extensive 5' UTR with one 37-residue uORF; ATF4 is poorlytranslated in unstressed cells but well-translated during ER stress, aminoacid starvation, or arsenite treatment; possibly atf-5 is alsotranslationally regulated in a way similar to ATF4. Curator_confirmed: WBPerson567
          Date_last_updated: 09 Aug 2006 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in hydrogen sulfide biosynthetic process and positive regulation of gene expression. Located in nucleus. Human ortholog(s) of this gene implicated in prostate carcinoma. Is an ortholog of human ATF4 (activating transcription factor 4) and ATF5 (activating transcription factor 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10286 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:786)
  Molecular_info: Corresponding_CDS: T04C10.4
    Corresponding_CDS_history: T04C10.4a:wp264
      T04C10.4b:wp264
    Corresponding_transcript: T04C10.4.1
    Other_sequence (24)
    Associated_feature: WBsf654606
      WBsf978443
      WBsf982291
      WBsf1008012
      WBsf1024465
      WBsf238254
    Transcription_factor: WBTranscriptionFactor000146
  Experimental_info: RNAi_result (5)
    Expr_pattern: Expr11023
      Expr1020406
      Expr1030138
      Expr1155993
      Expr2009480
      Expr2027717
    Drives_construct: WBCnstr00017860
      WBCnstr00037651
    Construct_product (2)
    Regulate_expr_cluster: WBPaper00062518:atf-4_regulated
    Microarray_results (19)
    Expression_cluster: WBPaper00028867:PAL-1_induced_TF
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00041222:unc-120(st364)_downregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044246:pgrn-1_ced-1_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045316:prg-1_upregulated_L1
      WBPaper00045316:prg-1_upregulated_L2
      WBPaper00045316:prg-1_upregulated_L3
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050332:juglone_upregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050332:skr-1(RNAi)-skr-2(RNAi)_downregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00054626:NO_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056218:daf-16(mu86)_upregulated_Day3
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059895:wounding_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:BWM_anterior
      WBPaper00061340:BWM_far_posterior
      WBPaper00061340:Coelomocyte
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:mup-2-unc-87_284
      WBPaper00061651:ASG_enriched
      WBPaper00061651:AUA_enriched
      WBPaper00061651:AWC_ON_enriched
      WBPaper00061651:BAG_enriched
      WBPaper00061651:Coelomocyte_enriched
      WBPaper00061651:Distal_tip_cell_enriched
      WBPaper00061651:PQR_enriched
      WBPaper00061651:PVT_enriched
      WBPaper00061651:Spermatheca_enriched
      WBPaper00061651:URX_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062518:atf-4_regulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:25C_vs_15C_upregulated_AFD
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_8
      WBPaper00025032:cluster_168
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027111:rrf-2(ok210)_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032062:age_regulated_genes
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036286:Pattern_C
      WBPaper00037695:WC_5-day
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:Q200_down
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055899:nitrotriazolone_regulated
      [cgc6390]:Cluster_C
    Interaction (27)
  Map_info: Map: X Position: 21.3687 Error: 0.007883
    Positive: Positive_clone: T04C10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4483
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene