WormBase Tree Display for Gene: WBGene00000097

WBGene00000097 SMap: S_parent: Sequence: F58E10
  Identity: Version: 1
    Name: CGC_name: aip-1 Person_evidence: WBPerson530
      Sequence_name: F58E10.4
      Molecular_name: F58E10.4
        F58E10.4.1
        CE18786
      Other_name: CELE_F58E10.4 Accession_evidence: NDB BX284605
      Public_name: aip-1
    DB_info: Database: AceView gene 5O493
        WormQTL gene WBGene00000097
        WormFlux gene WBGene00000097
        NDB locus_tag CELE_F58E10.4
        Panther gene CAEEL|WormBase=WBGene00000097|UniProtKB=Q9XUW8
          family PTHR14677
        NCBI gene 179898
        RefSeq protein NM_074078.4
        TREEFAM TREEFAM_ID TF314219
        TrEMBL UniProtAcc Q9XUW8
        UniProt_GCRP UniProtAcc Q9XUW8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aip
    Allele (11)
    Strain: WBStrain00035638
      WBStrain00036456
    RNASeq_FPKM (74)
    GO_annotation: 00102182
      00102183
      00102184
      00102185
      00102186
      00102187
      00102188
      00102189
      00102190
      00106777
    Ortholog (39)
    Structured_description: Concise_description: aip-1 encodes an AN-1-like zinc finger-containing protein homologous to arsenite-inducible RNA-associated protein (AIRAP), conserved among C. elegans, Drosophila, and mammals; like AIRAP itself, AIP-1 protects cells from arsenite toxicity; AIP-1 is a predicted RNA binding protein that may function in ubiquitin-mediated proteolysis following arsenite treatment; AIP-1 does not appear to be essential for viability, but is expressed at high levels in hypodermal and intestinal cells following such treatment. Paper_evidence: WBPaper00004641
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable zinc ion binding activity. Involved in cellular response to misfolded protein and response to arsenic-containing substance. Located in cytoplasm and nucleus. Expressed in body wall musculature; excretory cell; pharynx; and somatic gonad. Is an ortholog of human ZFAND2A (zinc finger AN1-type containing 2A) and ZFAND2B (zinc finger AN1-type containing 2B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Modifies_disease: DOID:10652
  Modifies_disease_in_annotation: WBDOannot00000387
  Molecular_info (4)
  Experimental_info: RNAi_result (25)
    Expr_pattern: Expr885
      Expr12709
      Expr1023652
      Expr1030047
      Expr1152736
      Expr2009274
      Expr2027511
    Drives_construct: WBCnstr00005154
      WBCnstr00005155
      WBCnstr00005156
      WBCnstr00018309
      WBCnstr00018310
      WBCnstr00037736
    Construct_product: WBCnstr00037736
    Antibody: WBAntibody00000360
    Microarray_results (20)
    Expression_cluster: WBPaper00032097:CGH-1-associated-mRNA
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:coelomocytes_larva_enriched
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044316:HgCl2_20uM_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00048762:FOG-3_associated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049266:NaAsO2-Stress_regulated_N2
      WBPaper00049266:NaAsO2-Stress_regulated_trx-1(ok1449)
      WBPaper00049489:AMsh-glia_enriched
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049954:BPS_downregulated
      WBPaper00050193:cec-4(ok3124)_upregulated_L1
      WBPaper00050332:juglone_upregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055648:sperm_expressed
      WBPaper00055897:heat-shock_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056619:CEPsh_enriched
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00058969:RIS_enriched
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059490:dcr-1(m9375)_downregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059598:HeatShock_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061340:PLM
      WBPaper00061340:Rectal_cell
      WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated
      WBPaper00061527:hars-1-cct-4_20449
      WBPaper00061651:AIA_enriched
      WBPaper00061651:ASH_enriched
      WBPaper00061651:ASI_enriched
      WBPaper00061651:ASK_enriched
      WBPaper00061651:AVB_enriched
      WBPaper00061651:AVD_enriched
      WBPaper00061651:AVG_enriched
      WBPaper00061651:AVH_enriched
      WBPaper00061651:AVM_enriched
      WBPaper00061651:DVA_enriched
      WBPaper00061651:I5_enriched
      WBPaper00061651:M5_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:PDE_enriched
      WBPaper00061651:PLN_enriched
      WBPaper00061651:PVP_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:RMD_DV_enriched
      WBPaper00061651:RMF_enriched
      WBPaper00061651:RMH_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SIB_enriched
      WBPaper00061651:SMB_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061651:VB_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062345:bortezomib_30min_upregulated_N2
      WBPaper00062345:bortezomib_30min_upregulated_zip-1(jy13)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064735:bet-1(uth41)_vs_N2_upregulated
      WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065945:global-rpoa-2(-)_upregulated_transcript
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:hda-3(ok1991)_downregulated
      cgc4489_group_8
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00034661:AgNPs_upregulated
      WBPaper00034739:N2lessDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00037147:heatshock_upregulated
      WBPaper00037611:RNP-8-associated
      WBPaper00037695:WC_5-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00043980:arsenic_upregulated
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00044535:male_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00055899:nitroguanidine_regulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(186_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_ME
    Interaction (31)
    WBProcess: WBbiopr:00000078
  Map_info: Map: V Position: 5.91965 Error: 0.0241
    Positive: Positive_clone: F58E10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4149
        4287
        4288
    Pseudo_map_position
  Reference (14)
  Remark: Sequence connection from [Sok J, Ron D]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene