WormBase Tree Display for Gene: WBGene00000214

WBGene00000214 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y39B6A
  Identity: Version: 1
    Name: CGC_name: asp-1 Person_evidence: WBPerson184
      Sequence_name: Y39B6A.20
      Molecular_name: Y39B6A.20
        Y39B6A.20.1
        CE21681
      Other_name: Y39B6B.g Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y39B6A.20 Accession_evidence: NDB BX284605
      Public_name: asp-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: asp
    Allele (35)
    Strain: WBStrain00001516
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (57)
    Paralog (18)
    Structured_description: Concise_description: asp-1 encodes a homolog of cathepsin D aspartic protease; it is transcribed exclusively in intestinal cells of the late embryo and early larvae and is not observed in older larvae or adults; ASP-1 is dispensable for neuronal degeneration. Paper_evidence: WBPaper00004299
            WBPaper00005513
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Located in cytoplasm and external side of apical plasma membrane. Expressed in intestinal cell and intestine. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic fatigue syndrome; and congenital adrenal hyperplasia. Is an ortholog of human PGC (progastricsin) and REN (renin). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (17)
  Molecular_info: Corresponding_CDS: Y39B6A.20
    Corresponding_transcript: Y39B6A.20.1
    Other_sequence (155)
    Associated_feature (18)
  Experimental_info: RNAi_result (17)
    Expr_pattern (12)
    Drives_construct: WBCnstr00002373
      WBCnstr00010076
      WBCnstr00022452
      WBCnstr00037658
    Construct_product: WBCnstr00010076
      WBCnstr00022452
      WBCnstr00037658
    Antibody: WBAntibody00000301
    Microarray_results (20)
    Expression_cluster: WBPaper00005943:L1_specific
      WBPaper00006047:15C_temperature_specific
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1678
      WBPaper00031486:daf-16_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00035926:A.hydrophila_regulated
      WBPaper00037109:cyclophilin-inhibitor_regulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00042477:rsr-2(RNAi)_upregulated_RNAseq
      WBPaper00044037:eat-2_downregulated
      WBPaper00044037:eat-2_regulated_nhr-62_dependent
      WBPaper00044128:daf-2(e1370)_downregulated
      WBPaper00044128:DietaryRestriction_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044638:daf-2(e1370)rsks-1(ok1255)_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045417:19Q-huntingtin_upreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046303:P.aeruginosa_downregulated_protein
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046499:AMPK_regulated
      WBPaper00048923:Aging_regulated
      WBPaper00048952:glucose_repressed
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_downregulated
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049484:elt-2(RNAi)_downregulated_L1
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049920:hyl-2(tm2031)_upregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050332:skr-1(RNAi)-skr-2(RNAi)_downregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050698:DEP-1_interacting
      WBPaper00050709:jmjd-1.2(tm3713)_regulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051039:intestine_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051352:Long-Term-Association-Memory_downregulated
      WBPaper00051461:pig-1(gm344)_downregulated
      WBPaper00051538:micro-gavity_upregulated_protein
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053020:sta-1(ok587)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053814:15C_upregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00053814:OP50_vs_PY79_downregulated_PY79
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055969:electromagnetic-field_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056139:gut-microbiota_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056284:ints-6(t1903)_downregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056826:hmc_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056900:PID-3_interacting
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058665:amino-functionized-graphene-oxide_upregulated_mRNA
      WBPaper00058665:graphene-oxide_upregulated_mRNA
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059334:SACY-1_interacting
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059477:lin-32(RNAi)_regulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:HB101_upregulated
      WBPaper00061040:eat-2(ad1116)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061393:C.albicans_regulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:F54D5.3_7003-F54D5.3_7004
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061651:Intestine_enriched
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061952:daf-18(nr2037)_upregulated
      WBPaper00062056:lin-35(n745)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00063976:micu-1(bon20)_downregulated
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064005:starvation_upregulated_N2_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064122:vulva_transcriptome
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064473:ets-4(rrr16)_downregulated
      WBPaper00064632:daf-2(e1370)_downregulated_intestine
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064735:bet-1(uth41)_vs_N2_upregulated
      WBPaper00064952:Day10_vs_L4_downregulated_25C
      WBPaper00065029:cadmium_upregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065392:Lb.rhamnosus_upregulated
      WBPaper00065623:5
      WBPaper00065623:13
      WBPaper00065623:20
      WBPaper00065623:23
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:3_0
      WBPaper00065841:3_1
      WBPaper00065841:3_2
      WBPaper00065841:3_4
      WBPaper00065841:3_5
      WBPaper00065877:rege-1(imm070)_upregulated_OP50
      WBPaper00065877:rege-1(imm070)_upregulated_PA14
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066085:sin-3(tm1276)_downregulated
      WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4386_cluster_1_4
      cgc4489_group_18
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00027758:Group_IV
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00035479:daf-16(RNAi)_upregulated
      WBPaper00035892:Y.pestis_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036286:Pattern_G
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00048567:dnj-14_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_allantoin_downregulated
      [cgc6390]:mixed_spermatogenesis-somatic
    Interaction (49)
    WBProcess: WBbiopr:00000134
  Map_info: Map: V Position: 18.5005 Error: 0.138896
    Positive: Positive_clone: Y39B6A Inferred_automatically: From sequence, transcript, pseudogene data
        Y39B6B
    Mapping_data: Multi_point: 4527
        5346
    Pseudo_map_position
  Reference: WBPaper00003229
    WBPaper00004299
    WBPaper00005295
    WBPaper00005513
    WBPaper00005943
    WBPaper00006047
    WBPaper00010948
    WBPaper00011059
    WBPaper00015519
    WBPaper00017646
    WBPaper00021771
    WBPaper00025088
    WBPaper00028758
    WBPaper00031025
    WBPaper00032014
    WBPaper00032322
    WBPaper00033099
    WBPaper00035577
    WBPaper00038491
    WBPaper00040135
    WBPaper00043869
    WBPaper00047146
    WBPaper00049138
    WBPaper00052366
    WBPaper00055090
    WBPaper00057998
    WBPaper00058665
    WBPaper00059755
    WBPaper00062277
    WBPaper00062473
    WBPaper00063976
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene