WBGene00010425 | SMap | S_parent | Sequence | H37A05 |
| Identity | Version | 2 |
| | Name | CGC_name | lpin-1 | Person_evidence | WBPerson8432 |
| | | Sequence_name | H37A05.1 |
| | | Molecular_name | H37A05.1 |
| | | | H37A05.1.1 |
| | | | CE46619 |
| | | Other_name | CELE_H37A05.1 | Accession_evidence | NDB | BX284605 |
| | | Public_name | lpin-1 |
| | DB_info | Database | AceView | gene | 5O132 |
| | | | WormQTL | gene | WBGene00010425 |
| | | | WormFlux | gene | WBGene00010425 |
| | | | NDB | locus_tag | CELE_H37A05.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00010425|UniProtKB=Q9XXT5 |
| | | | | family | PTHR12181 |
| | | | NCBI | gene | 179853 |
| | | | RefSeq | protein | NM_073979.7 |
| | | | TREEFAM | TREEFAM_ID | TF314095 |
| | | | TrEMBL | UniProtAcc | Q9XXT5 |
| | | | UniProt_GCRP | UniProtAcc | Q9XXT5 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 15 Sep 2008 11:24:05 | WBPerson2970 | Name_change | CGC_name | lpin-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lpin |
| | Allele (56) |
| | Strain | WBStrain00001552 |
| | | WBStrain00029193 |
| | | WBStrain00029194 |
| | | WBStrain00037085 |
| | | WBStrain00053909 |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Ortholog (49) |
| | Structured_description | Concise_description | lpin-1 encodes a putative phosphatidic acid phosphatase orthologous tobudding yeast PAH1 and human LPIN1 (OMIM:605518), LPIN2 (OMIM:605519,mutated in Majeed syndrome), and LPIN3 (OMIM:605520); lpin-1 isexpressed in vulval muscle; in mass RNAi assays, lpin-1 is requiredfor the osmotic integrity of eggs and for normal larval growth, bodythickness, locomotion, and fertility; by orthology, LPIN-1 is expectedto be dephosphorylated by SCPL-2. | Paper_evidence | WBPaper00005654 |
| | | | | | WBPaper00006525 |
| | | | | | WBPaper00024497 |
| | | | | | WBPaper00025054 |
| | | | | | WBPaper00029274 |
| | | | | | WBPaper00029281 |
| | | | | | WBPaper00029282 |
| | | | | | WBPaper00029283 |
| | | | | | WBPaper00029284 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2009 00:00:00 |
| | | Automated_description | Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Involved in several processes, including endomembrane system organization; macromolecule localization; and nematode larval development. Located in endoplasmic reticulum; nuclear envelope; and nucleoplasm. Expressed in head neurons and hypodermis. Used to study obesity. Human ortholog(s) of this gene implicated in morbid obesity. Is an ortholog of human LPIN2 (lipin 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00033438 |
| | | | | Curator_confirmed | WBPerson38202 |
| | | | | Date_last_updated | 11 Jun 2018 00:00:00 |
| | Potential_model | DOID:11981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13345) |
| Models_disease_asserted | WBDOannot00000542 |
| Molecular_info | Corresponding_CDS | H37A05.1 |
| | Corresponding_CDS_history | H37A05.1:wp229 |
| | Corresponding_transcript | H37A05.1.1 |
| | Other_sequence (51) |
| | Associated_feature (20) |
| Experimental_info | RNAi_result | WBRNAi00080924 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00111106 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080841 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080927 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00116421 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080917 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080837 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080928 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080849 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080922 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080838 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00071589 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090842 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080923 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080932 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080835 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00106035 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080926 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080834 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080840 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00106799 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00085625 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00102769 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080836 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00000191 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080831 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00049542 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080918 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080942 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080919 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080921 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080931 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080936 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00008933 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080940 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080830 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080937 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080934 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080925 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080848 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080933 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086025 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080935 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080930 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080846 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080850 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080939 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080833 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00091141 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00105938 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080847 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080844 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00091138 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00071647 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080845 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00091140 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00091139 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080842 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080929 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00033778 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080920 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080941 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080839 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080829 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00080843 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Chronogram1159 |
| | | Expr6290 |
| | | Expr8650 |
| | | Expr8695 |
| | | Expr11676 |
| | | Expr1026973 |
| | | Expr1034547 |
| | | Expr1153265 |
| | | Expr2013257 |
| | | Expr2031488 |
| | Drives_construct | WBCnstr00002394 |
| | | WBCnstr00013464 |
| | | WBCnstr00015871 |
| | | WBCnstr00015872 |
| | Construct_product | WBCnstr00013464 |
| | | WBCnstr00015871 |
| | | WBCnstr00019172 |
| | Antibody | WBAntibody00001937 |
| | | WBAntibody00001938 |
| | | WBAntibody00001939 |
| | | WBAntibody00001940 |
| | | WBAntibody00002523 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00029359_1217 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1353 |
| | | WBPaper00029359_1419 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1548 |
| | | WBPaper00029359_1604 |
| | | WBPaper00032031:DConiospora_upregulated_OligoArray_24h |
| | | WBPaper00032425:down_in_rde-4 |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPS_downregulated |
| | | WBPaper00050080:rbr-2(tm3141)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050514:CEBP-1_interacting |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053295:lin-22(ot267)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060458:rnf-5(tm794)_regulated |
| | | WBPaper00061340:G2_and_W_blasts |
| | | WBPaper00061340:Intestinal_and_rectal_muscle |
| | | WBPaper00061527:gpb-1_3783-C48A7.2_22459 |
| | | WBPaper00061527:trcs-2_5724-R11A8.7_17645 |
| | | WBPaper00061902:camt-1(ok515)_regulated_AFD |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_protein |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065945:epidermis-rpoa-2(-)_downregulated_transcript |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein |
| | | WBPaper00065945:global-rpoa-2(-)_downregulated_transcript |
| | | cgc4386_cluster_3_3 |
| | | cgc4489_group_7 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031060:2-deoxy-D-glucose_downregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_5 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040963:Q200_up |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042128:gei-8(ok1671)_downregulated |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00055899:nitroguanidine_regulated |
| | Interaction (15) |
| Map_info | Map | V | Position | 5.54896 | Error | 0.007081 |
| | Positive | Positive_clone | H37A05 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00033438 |
| | WBPaper00033439 |
| | WBPaper00038491 |
| | WBPaper00040466 |
| | WBPaper00042257 |
| | WBPaper00045023 |
| | WBPaper00047716 |
| | WBPaper00051953 |
| | WBPaper00055090 |
| | WBPaper00059735 |
| | WBPaper00062852 |
| | WBPaper00064071 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |