WormBase Tree Display for Gene: WBGene00010423

WBGene00010423 SMap: S_parent: Sequence: H36L18
  Identity: Version: 2
    Name: CGC_name: zmp-5 Paper_evidence: WBPaper00036427
          Person_evidence: WBPerson345
      Sequence_name: H36L18.1
      Molecular_name: H36L18.1
        H36L18.1.1
        CE51780
      Other_name: CELE_H36L18.1 Accession_evidence: NDB BX284606
      Public_name: zmp-5
    DB_info: Database: AceView gene XN269
        WormQTL gene WBGene00010423
        WormFlux gene WBGene00010423
        NDB locus_tag CELE_H36L18.1
        Panther gene CAEEL|WormBase=WBGene00010423|UniProtKB=O17913
          family PTHR10201
        NCBI gene 186805
        RefSeq protein NM_001346619.2
        TrEMBL UniProtAcc O17913
        UniProt_GCRP UniProtAcc O17913
        OMIM gene 120353
            600108
            600754
            604629
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 04 Jan 2016 15:29:00 WBPerson2970 Name_change: CGC_name: zmp-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: zmp
    Allele (75)
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog: WBGene00023583 Caenorhabditis briggsae From_analysis: OrthoMCL
            Inparanoid_8
            WormBase-Compara
      WBGene00051150 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00153096 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00151114 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00130315 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00055542 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00061033 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00064350 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00151017 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00224951 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2764 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP26.g19776 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g17695 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g20579 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g5627 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g14179 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g3523 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g5678 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g12143 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00001.g110 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-zmp-5 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18798 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01544.g21605 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_03378 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024969 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g09010 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g14154 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_X0222700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      WBGene00122094 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00246226 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00205290 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00260882 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00293555 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0035049 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030901-1 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-031202-2 Danio rerio From_analysis: OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070817-4 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070817-3 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070817-2 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030901-2 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070820-2 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-040724-262 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-061009-22 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060421-5765 Danio rerio From_analysis: OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070820-22 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-100226-1 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-6152 Danio rerio From_analysis: OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070817-6 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-100308-4 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-100308-3 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7155 Homo sapiens From_analysis: OrthoInspector
            Panther
            SonicParanoid
      HGNC:7173 Homo sapiens From_analysis: OrthoInspector
            Panther
            SonicParanoid
      HGNC:7175 Homo sapiens From_analysis: OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7156 Homo sapiens From_analysis: OrthoInspector
            Panther
            SonicParanoid
      HGNC:7157 Homo sapiens From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7158 Homo sapiens From_analysis: OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7159 Homo sapiens From_analysis: OrthoInspector
            Panther
            SonicParanoid
      HGNC:7160 Homo sapiens From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7161 Homo sapiens From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7162 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7163 Homo sapiens From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      HGNC:7165 Homo sapiens From_analysis: Inparanoid
            OrthoInspector
            Panther
      HGNC:7167 Homo sapiens From_analysis: OrthoInspector
            Panther
            SonicParanoid
      HGNC:7172 Homo sapiens From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:14250 Homo sapiens From_analysis: OrthoInspector
            Panther
            SonicParanoid
      HGNC:14246 Homo sapiens From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      MGI:97005 Mus musculus From_analysis: OMA
            OrthoInspector
            Panther
      MGI:97007 Mus musculus From_analysis: OrthoInspector
            Panther
            SonicParanoid
      MGI:97008 Mus musculus From_analysis: OrthoInspector
            Panther
            SonicParanoid
      MGI:1340026 Mus musculus From_analysis: OrthoInspector
            Panther
            SonicParanoid
      MGI:101900 Mus musculus From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:109320 Mus musculus From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1276107 Mus musculus From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1341867 Mus musculus From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:97010 Mus musculus From_analysis: OrthoInspector
            Panther
            SonicParanoid
      MGI:1202395 Mus musculus From_analysis: OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1353466 Mus musculus From_analysis: OrthoInspector
            Panther
            SonicParanoid
      MGI:1927899 Mus musculus From_analysis: OrthoInspector
            Panther
            SonicParanoid
      MGI:2153062 Mus musculus From_analysis: OrthoInspector
            Panther
            SonicParanoid
      RGD:3099 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:631408 Rattus norvegicus From_analysis: OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620199 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620198 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620202 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620195 Rattus norvegicus From_analysis: OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620192 Rattus norvegicus From_analysis: OrthoInspector
            Panther
            SonicParanoid
      RGD:621317 Rattus norvegicus From_analysis: OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620196 Rattus norvegicus From_analysis: OrthoInspector
            Panther
            SonicParanoid
      RGD:1308937 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1306642 Rattus norvegicus From_analysis: OrthoInspector
            Panther
            SonicParanoid
      RGD:1308730 Rattus norvegicus From_analysis: OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00006987 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00016283 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020646 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00019212 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00012364 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00012185 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010524 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00194737 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to be located in extracellular space. Expressed in dorsal uterine cell. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); and carcinoma (multiple). Is an ortholog of human MMP16 (matrix metallopeptidase 16). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (79)
  Molecular_info: Corresponding_CDS: H36L18.1
    Corresponding_CDS_history: H36L18.1:wp57
      H36L18.1:wp195
      H36L18.1:wp204
      H36L18.1:wp255
    Corresponding_transcript: H36L18.1.1
    Other_sequence: CBC00808_1
      CJC11219_1
      JI168618.1
      TSC15083_1
      ES566925.1
    Associated_feature (13)
  Experimental_info: RNAi_result: WBRNAi00049540 Inferred_automatically: RNAi_primary
      WBRNAi00089102 Inferred_automatically: RNAi_primary
      WBRNAi00016344 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr14540
      Expr1014675
      Expr1034546
      Expr1153263
      Expr2018182
      Expr2036319
    Drives_construct: WBCnstr00031425
      WBCnstr00040504
      WBCnstr00041080
    Construct_product: WBCnstr00031425
    Microarray_results (18)
    Expression_cluster: WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00046121:ecdoderm_unique
      WBPaper00048988:daf-2(e1370)_daf-16(mu86)_downregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049377:MWCNT_upregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053888:drh-3(rrr2)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Metformin_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060886:spr-5(by101);met-2(n4256)_upregulated
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ABarpaaa_lineage
      WBPaper00061340:ADEsh
      WBPaper00061340:CEPsh
      WBPaper00061340:CEPso
      WBPaper00061340:DB
      WBPaper00061340:DD
      WBPaper00061340:Glia
      WBPaper00061340:IL1
      WBPaper00061340:IL2
      WBPaper00061340:ILsh_OLLsh_OLQsh
      WBPaper00061340:ILso
      WBPaper00061340:Neuroblast_HSN_PHB
      WBPaper00061340:OLL
      WBPaper00061340:PLM_ALN_grandparent
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061340:PVR
      WBPaper00061340:RIC
      WBPaper00061340:RIV
      WBPaper00061340:RME
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061527:grl-1-F53A9.3
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00064532:pals-22(jy3)_upregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065841:38_2
      WBPaper00065841:44_1
      WBPaper00065841:49_0
      WBPaper00065841:64_0
      WBPaper00065841:73_0
      WBPaper00065841:122_0
      WBPaper00065841:130_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00027111:rde-3(r459)_upregulated
      WBPaper00027111:rrf-2(ok210)_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00046548:dafachronic-acid_upregulated
    Interaction: WBInteraction000036487
      WBInteraction000361409
      WBInteraction000367196
      WBInteraction000403409
      WBInteraction000428765
      WBInteraction000429917
      WBInteraction000439710
  Map_info: Map: X Position: 7.47464
    Positive: Positive_clone: H36L18 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00056095
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene