| WBGene00006543 | SMap | S_parent | Sequence | F21H11 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | tbx-2 | Person_evidence | WBPerson107 |
| | | Sequence_name | F21H11.3 |
| | | Molecular_name | F21H11.3 |
| | | | F21H11.3.1 |
| | | | CE01245 |
| | | Other_name | sdf-13 |
| | | | mab-22 | Person_evidence | WBPerson261 |
| | | | CELE_F21H11.3 | Accession_evidence | NDB | BX284603 |
| | | Public_name | tbx-2 |
| | DB_info | Database | AceView | gene | 3G222 |
| | | | WormQTL | gene | WBGene00006543 |
| | | | WormFlux | gene | WBGene00006543 |
| | | | NDB | locus_tag | CELE_F21H11.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006543|UniProtKB=Q19691 |
| | | | | family | PTHR11267 |
| | | | NCBI | gene | 175698 |
| | | | RefSeq | protein | NM_001382860.2 |
| | | | SwissProt | UniProtAcc | Q19691 |
| | | | UniProt_GCRP | UniProtAcc | Q19691 |
| | | | OMIM | gene | 600747 |
| | | | | | 601621 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 31 Jul 2013 13:40:41 | WBPerson2970 | Event | Acquires_merge | WBGene00003113 |
| | | | | | | Name_change | Other_name | mab-22 |
| | | Acquires_merge | WBGene00003113 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | tbx |
| | Allele (60) |
| | Legacy_information | [C.elegansII] NMK. Similarity to mouse Tbx genes, closest to mouse Tbx2 (70% identity in T box domain). (F21H11.3)[Agulnik et al. 1995] |
| | | [C.elegansII] bx59ts : extensive loss of rays at 25C, not 15C. Divisions appear normal, possible ray assembly defect. NA1. [EM] |
| | Strain | WBStrain00003711 |
| | | WBStrain00022191 |
| | | WBStrain00022192 |
| | | WBStrain00035675 |
| | | WBStrain00007174 |
| | | WBStrain00049269 |
| | RNASeq_FPKM (74) |
| | GO_annotation (35) |
| | Ortholog (42) |
| | Paralog (21) |
| | Structured_description | Concise_description | tbx-2 encodes one of 21 C. elegans T-box transcription factors; during development, tbx-2 activity is required for normal adaptation, but not chemotaxis, to attractive odorants sensed by the AWC amphid neurons; tbx-2 is required redundantly with unc-3 and unc-31 for negative regulation of dauer formation, and large-scale RNAi screens reveal an essential role for tbx-2 in early larval development, normal rates of postembryonic growth, and locomotory behavior; tbx-2 is also required along with pha-4 for embryonic precursor cells to adopt a pharyngeal muscle fate; TBX-2 and PHA-4 are mutually dependant on each other to maintain expression implicating them in a regulatory loop that controls commitment to the pharyngeal muscle fate; yeast two-hybrid assays have identified that TBX-2 interacts with UBC-9 (E2 SUMO conjugating enzyme) and GEI-17 (E3 SUMO ligase); based on the two-hybrid interaction and the similar pharyngeal muscle phenotype of ubc-9, it is likely that protein sumoylation is required for precursor-cell derived pharyngeal muscle development; antibodies to TBX-2 detect expression in the cytoplasm of amphid and pharyngeal neurons in larvae and adults, suggesting that TBX-2 function may be controlled, in part, by regulation of its subcellular localization; in addition, in situ hybridization studies indicate that tbx-2 mRNA is expressed during mid-embryogenesis; tbx-2 expression in the AWC amphid neurons is sufficient to rescue the olfactory adaptation defects seen in tbx-2 mutant animals. | Paper_evidence | WBPaper00002132 |
| | | | | | WBPaper00002863 |
| | | | | | WBPaper00004103 |
| | | | | | WBPaper00005423 |
| | | | | | WBPaper00006381 |
| | | | | | WBPaper00025054 |
| | | | | | WBPaper00027631 |
| | | | | | WBPaper00028546 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 16 Mar 2007 00:00:00 |
| | | Automated_description | Enables DNA-binding transcription repressor activity; core promoter sequence-specific DNA binding activity; and enzyme binding activity. Involved in several processes, including muscle structure development; neuron migration; and olfactory behavior. Located in cytoplasm and nucleus. Expressed in amphid neurons; body wall musculature; head neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); ulnar-mammary syndrome; and vertebral anomalies and variable endocrine and T-cell dysfunction. Is an ortholog of human TBX2 (T-box transcription factor 2) and TBX3 (T-box transcription factor 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) |
| | | DOID:0060614 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) |
| | | DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) |
| | | DOID:1882 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11597) |
| | | DOID:1681 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11597) |
| | | DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) |
| | | DOID:0070345 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11597) |
| | | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) |
| Molecular_info | Corresponding_CDS | F21H11.3 |
| | Corresponding_transcript | F21H11.3.1 |
| | Other_sequence (16) |
| | Associated_feature (13) |
| | Gene_product_binds | WBsf977981 |
| | | WBsf977982 |
| | | WBsf977983 |
| | Transcription_factor | WBTranscriptionFactor000208 |
| Experimental_info | RNAi_result (16) |
| | Expr_pattern (16) |
| | Drives_construct (12) |
| | Construct_product | WBCnstr00011882 |
| | | WBCnstr00011883 |
| | | WBCnstr00034310 |
| | Regulate_expr_cluster | WBPaper00042274:tbx-2(bx59)_downregulated |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | Antibody | WBAntibody00000713 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00024505:pharyngeal_enriched |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045316:prg-1_upregulated_L3 |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00045861:wdr-5(ok1417)_upregulated |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00046887:WNT-target |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049001:EVN_enriched |
| | | WBPaper00049018:swsn-2.2(RNAi)_upregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPS_upregulated |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00059117:B.subtilis_upregulated |
| | | WBPaper00059440:GLP-1_activated |
| | | WBPaper00059440:LAG-1_activated_4hr-auxin |
| | | WBPaper00059440:LAG-1_activated_48hr-auxin |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_adult |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060526:plp-1(ok2155)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADA_ADE_grandparent |
| | | WBPaper00061340:ADE |
| | | WBPaper00061340:ADEsh |
| | | WBPaper00061340:ASK_parent |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:GLR |
| | | WBPaper00061340:I5 |
| | | WBPaper00061340:mc2 |
| | | WBPaper00061340:Neuroblast_AIZ_FLP_RMG |
| | | WBPaper00061340:Neuroblast_HSN_PHB |
| | | WBPaper00061340:Neuroblast_M2_M3 |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:OLL_parent |
| | | WBPaper00061340:Parent_of_g1P_I3 |
| | | WBPaper00061340:Pharyngeal_marginal_cell |
| | | WBPaper00061340:PLM_ALN_great_grandparent |
| | | WBPaper00061340:pm3_pm4_pm5 |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RMED |
| | | WBPaper00061478:pie-1(ne4433)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:ADE_enriched |
| | | WBPaper00061651:ALN_enriched |
| | | WBPaper00061651:AVA_enriched |
| | | WBPaper00061651:AVD_enriched |
| | | WBPaper00061651:AVH_enriched |
| | | WBPaper00061651:I3_enriched |
| | | WBPaper00061651:I5_enriched |
| | | WBPaper00061651:I6_enriched |
| | | WBPaper00061651:IL2_LR_enriched |
| | | WBPaper00061651:LUA_enriched |
| | | WBPaper00061651:M2_enriched |
| | | WBPaper00061651:MC_enriched |
| | | WBPaper00061651:OLL_enriched |
| | | WBPaper00061651:PDE_enriched |
| | | WBPaper00061651:PHA_enriched |
| | | WBPaper00061651:PLN_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:RID_enriched |
| | | WBPaper00061651:RMG_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062590:Aging_downregulated_body-wall-muscle |
| | | WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065841:25_1 |
| | | WBPaper00065841:28_0 |
| | | WBPaper00065841:34_0 |
| | | WBPaper00065841:36_2 |
| | | WBPaper00065841:36_3 |
| | | WBPaper00065841:49_0 |
| | | WBPaper00065841:56_0 |
| | | WBPaper00065841:61_0 |
| | | WBPaper00065841:67_0 |
| | | WBPaper00065841:75_0 |
| | | WBPaper00065841:100_0 |
| | | WBPaper00065841:105_0 |
| | | WBPaper00065841:107_0 |
| | | WBPaper00065841:108_0 |
| | | WBPaper00065841:125_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065841:135_0 |
| | | WBPaper00065841:137_0 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_6_4 |
| | | WBPaper00025032:cluster_115 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00033101:spr-5_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00038172:aak-2overexpression_down_regulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(143_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction | WBInteraction000007568 |
| | | WBInteraction000009763 |
| | | WBInteraction000028815 |
| | | WBInteraction000028816 |
| | | WBInteraction000028817 |
| | | WBInteraction000032767 |
| | | WBInteraction000033466 |
| | | WBInteraction000034255 |
| | | WBInteraction000034273 |
| | | WBInteraction000034721 |
| | | WBInteraction000038141 |
| | | WBInteraction000038327 |
| | | WBInteraction000038871 |
| | | WBInteraction000040177 |
| | | WBInteraction000041388 |
| | | WBInteraction000042980 |
| | | WBInteraction000043229 |
| | | WBInteraction000043230 |
| | | WBInteraction000043231 |
| | | WBInteraction000045103 |
| | | WBInteraction000045105 |
| | | WBInteraction000045535 |
| | | WBInteraction000122941 |
| | | WBInteraction000173926 |
| | | WBInteraction000292497 |
| | | WBInteraction000325638 |
| | | WBInteraction000393896 |
| | | WBInteraction000406281 |
| | | WBInteraction000411045 |
| | | WBInteraction000414330 |
| | | WBInteraction000425735 |
| | | WBInteraction000430856 |
| | | WBInteraction000432952 |
| | | WBInteraction000447961 |
| | | WBInteraction000448011 |
| | | WBInteraction000502384 |
| | | WBInteraction000502644 |
| | | WBInteraction000502645 |
| | | WBInteraction000502646 |
| | | WBInteraction000502647 |
| | | WBInteraction000505573 |
| | | WBInteraction000505574 |
| | | WBInteraction000505575 |
| | | WBInteraction000519287 |
| | | WBInteraction000520057 |
| | | WBInteraction000520426 |
| | | WBInteraction000523860 |
| | | WBInteraction000525240 |
| | | WBInteraction000525241 |
| | | WBInteraction000525242 |
| | | WBInteraction000525243 |
| | | WBInteraction000525262 |
| | | WBInteraction000525263 |
| | | WBInteraction000525264 |
| | | WBInteraction000535338 |
| | | WBInteraction000539984 |
| | | WBInteraction000542305 |
| | | WBInteraction000542306 |
| | | WBInteraction000542307 |
| | | WBInteraction000542308 |
| | | WBInteraction000542309 |
| | | WBInteraction000555265 |
| | Anatomy_function | WBbtf0263 |
| | | WBbtf0264 |
| Map_info | Map | III | Position | -2.08974 | Error | 0.015753 |
| | Positive | Positive_clone | F21H11 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4725 |
| | Pseudo_map_position |
| Reference (58) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
