| WBGene00000492 | SMap | S_parent | Sequence | F59C6 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | che-13 | Person_evidence | WBPerson261 |
| | | Sequence_name | F59C6.7 |
| | | Molecular_name | F59C6.7a |
| | | | F59C6.7a.1 |
| | | | CE31704 |
| | | | F59C6.7b |
| | | | CE11472 |
| | | | F59C6.7b.1 |
| | | Other_name | che-9 |
| | | | CELE_F59C6.7 | Accession_evidence | NDB | BX284601 |
| | | Public_name | che-13 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | che |
| | Reference_allele | WBVar00144317 |
| | Allele (114) |
| | Legacy_information | e1805 : no FITC uptake by amphids or phasmids; severely shortened axonemes and ectopic assembly of ciliary structures and microtubules in many sensory neurons; defective in osmotic avoidance and dauer formation. ES1 ME0. NA1. |
| | | See also e1805 |
| | | [C.elegansII] e1805 : Dyf (no FITC uptake by amphids or phasmids); severely shortened axonemes and ectopic assembly of ciliary structures and microtubules in many sensory neurons; defective in osmotic avoidance and dauer formation. ES1 ME0. OA2: m523mut, n1520. [Perkins et al. 1986; Starich et al. 1995; DR; SP] |
| | Strain | WBStrain00027075 |
| | | WBStrain00004474 |
| | RNASeq_FPKM (74) |
| | GO_annotation (23) |
| | Ortholog (43) |
| | Structured_description | Concise_description | che-13 encodes a novel protein homologous to mammalian IFT57/Hippi; CHE-13 is a proposed component of the intraflagellar transport (IFT) complex B, and is required for the construction and maintenance of cilia on a subset of sensory neurons; in addition, CHE-13 is required for proper localization of OSM-5, a murine polaris homolog, to IFT complex B; CHE-13 is expressed in ciliated sensory neurons including the amphids, phasmids, inner and outer labial neurons, and sensory rays of the male tail, localizing to the cilia base (transition zone) as well as to the axoneme; che-13 expression, like that of ciliogenic genes osm-1, osm-5, osm-6, and che-2, is positively regulated by the DAF-19 RFX-type transcription factor. | Paper_evidence | WBPaper00000932 |
| | | | | | WBPaper00005786 |
| | | | | | WBPaper00013290 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Involved in chemosensory behavior; cilium organization; and protein localization. Located in axoneme; ciliary basal body; and ciliary transition zone. Part of intraciliary transport particle B. Expressed in neurons. Used to study ciliopathy. Human ortholog(s) of this gene implicated in orofaciodigital syndrome. Is an ortholog of human IFT57 (intraflagellar transport 57). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:0060340 | Homo sapiens | Paper_evidence | WBPaper00005786 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 13 Mar 2023 00:00:00 |
| | Potential_model | DOID:4501 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17367) |
| | Disease_relevance | Mammalian IFT57/HIPPI is a protein that interacts with Huntingtin-interacting protein 1, that is implicated in neuronal apoptosis in the Huntington disease state; in elegans, the HIPPI ortholog, che-13, is a intraflagellar transport (IFT) protein involved in ciliogenesis. | Homo sapiens | Paper_evidence | WBPaper00005786 |
| | | | | Accession_evidence | OMIM | 606621 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 18 Jul 2013 00:00:00 |
| Models_disease_asserted | WBDOannot00000211 |
| Molecular_info | Corresponding_CDS | F59C6.7a |
| | | F59C6.7b |
| | Corresponding_CDS_history | F59C6.7:wp84 |
| | Corresponding_transcript | F59C6.7a.1 |
| | | F59C6.7b.1 |
| | Other_sequence (14) |
| | Associated_feature | WBsf047492 |
| | | WBsf649581 |
| | | WBsf664880 |
| | | WBsf985022 |
| | | WBsf985023 |
| | | WBsf220252 |
| Experimental_info | RNAi_result | WBRNAi00003870 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00003868 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00095204 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00049167 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00049166 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr2371 |
| | | Expr2373 |
| | | Expr10108 |
| | | Expr1023700 |
| | | Expr1030290 |
| | | Expr1152913 |
| | | Expr2009962 |
| | | Expr2028202 |
| | Drives_construct (18) |
| | Construct_product | WBCnstr00006792 |
| | | WBCnstr00006793 |
| | | WBCnstr00006796 |
| | | WBCnstr00007469 |
| | | WBCnstr00008462 |
| | | WBCnstr00037499 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:BAG-neuron_embryo_enriched |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_CoreEnriched |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040560:hpl-2_embryo_upregulated |
| | | WBPaper00040731:Static_Magnetic_Field_downregulated |
| | | WBPaper00042561:smg-2(RNAi)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045420:fertilization_upregulated_transcript |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C |
| | | WBPaper00050743:elli-1(sam-3)_downregulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_upregulated_ClassI |
| | | WBPaper00053318:Aging_downregulated_mRNA_N2 |
| | | WBPaper00053318:mir-71(n4115)_downregulated_mRNA |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055386:daf-2(e1370)_upregulated |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00057041:spc-1(cas971)_downregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00057136:yap-1(ys38)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059194:KLF-1_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADE |
| | | WBPaper00061340:ADF |
| | | WBPaper00061340:ADF_AWB |
| | | WBPaper00061340:ADL |
| | | WBPaper00061340:AFD |
| | | WBPaper00061340:ASE |
| | | WBPaper00061340:ASE_parent |
| | | WBPaper00061340:ASG |
| | | WBPaper00061340:ASG_AWA |
| | | WBPaper00061340:ASH |
| | | WBPaper00061340:ASI |
| | | WBPaper00061340:ASI_parent |
| | | WBPaper00061340:ASJ |
| | | WBPaper00061340:ASK |
| | | WBPaper00061340:ASK_parent |
| | | WBPaper00061340:AUA |
| | | WBPaper00061340:AWA |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:AWC |
| | | WBPaper00061340:BAG |
| | | WBPaper00061340:CEP |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061340:IL2 |
| | | WBPaper00061340:Neuroblast_ADE_ADA |
| | | WBPaper00061340:Neuroblast_ASG_AWA |
| | | WBPaper00061340:Neuroblast_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_HSN_PHB |
| | | WBPaper00061340:Neuroblast_URX_CEPDx |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:OLL_parent |
| | | WBPaper00061340:OLQ |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061340:URX |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061478:pie-1(ne4433)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:rab-28-jbts-14_9542 |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:ADF_enriched |
| | | WBPaper00061651:ADL_enriched |
| | | WBPaper00061651:AQR_enriched |
| | | WBPaper00061651:ASG_enriched |
| | | WBPaper00061651:ASI_enriched |
| | | WBPaper00061651:ASK_enriched |
| | | WBPaper00061651:AWC_OFF_enriched |
| | | WBPaper00061651:PDE_enriched |
| | | WBPaper00061651:PHA_enriched |
| | | WBPaper00061651:PHB_enriched |
| | | WBPaper00061651:PQR_enriched |
| | | WBPaper00061651:URX_enriched |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-1.2(zr1010)_upregulated |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_downregulated_N2 |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064632:daf-2(e1370)_upregulated_intestine |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:36_0 |
| | | WBPaper00065841:36_2 |
| | | WBPaper00065841:36_3 |
| | | WBPaper00065841:38_1 |
| | | WBPaper00065841:39_0 |
| | | WBPaper00065841:39_1 |
| | | WBPaper00065841:39_2 |
| | | WBPaper00065841:47_0 |
| | | WBPaper00065841:71_0 |
| | | WBPaper00065841:100_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00065995:M.humicola-extract_downregulated_N2 |
| | | WBPaper00066110:Doxorubicin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4386_cluster_6_5 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Photorhabdus_luminescens_downregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_2 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00039866:ClassComp_daf-19_downregulated |
| | | WBPaper00039866:SAM_daf-19_downregulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00041939:control_vs_EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo |
| | Interaction | WBInteraction000126671 |
| | | WBInteraction000126694 |
| | | WBInteraction000126737 |
| | | WBInteraction000126762 |
| | | WBInteraction000135924 |
| | | WBInteraction000140832 |
| | | WBInteraction000140833 |
| | | WBInteraction000140837 |
| | | WBInteraction000143124 |
| | | WBInteraction000145280 |
| | | WBInteraction000149156 |
| | | WBInteraction000149167 |
| | | WBInteraction000151156 |
| | | WBInteraction000153216 |
| | | WBInteraction000170305 |
| | | WBInteraction000185289 |
| | | WBInteraction000348532 |
| | | WBInteraction000389066 |
| | | WBInteraction000418336 |
| | | WBInteraction000501852 |
| | | WBInteraction000502869 |
| | | WBInteraction000503522 |
| | | WBInteraction000520976 |
| | | WBInteraction000541728 |
| | | WBInteraction000542902 |
| | | WBInteraction000542915 |
| Map_info | Map | I | Position | 5.05454 | Error | 0.000234 |
| | Positive | Positive_clone | F59C6 | Person_evidence | WBPerson1662 |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 788 |
| | | | 2591 |
| | | Multi_point | 720 |
| | | | 3046 |
| | | | 5617 |
| | | Pos_neg_data | 8307 |
| | | | 8308 |
| | | | 8309 |
| | | | 8310 |
| Reference (57) |
| Remark | Sequence connection from [Haycraft CJ, Yoder BK],[020809 krb] |
| Method | Gene |
