WormBase Tree Display for Gene: WBGene00000277

WBGene00000277 SMap: S_parent: Sequence: C23H4
  Identity: Version: 1
    Name: CGC_name: cab-1 Person_evidence: WBPerson287
      Sequence_name: C23H4.1
      Molecular_name: C23H4.1
        C23H4.1.1
        CE17435
        C23H4.1.2
      Other_name: CELE_C23H4.1 Accession_evidence: NDB BX284606
      Public_name: cab-1
    DB_info: Database: AceView gene XM818
        WormQTL gene WBGene00000277
        WormFlux gene WBGene00000277
        NDB locus_tag CELE_C23H4.1
        Panther gene CAEEL|WormBase=WBGene00000277|UniProtKB=Q93249
          family PTHR23352
        NCBI gene 181382
        RefSeq protein NM_077635.7
        SwissProt UniProtAcc Q93249
        TREEFAM TREEFAM_ID TF318443
        UniProt_GCRP UniProtAcc Q93249
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cab
    Allele (214)
    Strain: WBStrain00024085
    RNASeq_FPKM (74)
    GO_annotation: 00085642
      00085643
      00085644
      00085645
      00085646
      00085647
      00107160
    Ortholog (34)
    Structured_description: Concise_description: Novel protein which has a C-terminal motif weakly homologous to mouse NPDC-1 and is involved in synaptic regulation; it is expressed in various neurons including ventral cord and tail ganglion neurons; it physically interacts with AEX-3, which is a guanine nucleotide exchange factor for the Rab3 GTPase. Paper_evidence: WBPaper00004331
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Involved in chemical synaptic transmission; positive regulation of anterior/posterior axon guidance; and ventral cord development. Predicted to be located in membrane and synapse. Is an ortholog of human NPDC1 (neural proliferation, differentiation and control 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C23H4.1
    Corresponding_transcript: C23H4.1.1
      C23H4.1.2
    Other_sequence (74)
    Associated_feature (22)
  Experimental_info: RNAi_result (22)
    Expr_pattern (5)
    Microarray_results (29)
    Expression_cluster: WBPaper00031040:Cluster_3
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00032976:dosage_compensated_genes
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040990:PA14_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00045861:ash-2(tm1095)_upregulated
      WBPaper00046691:P1_enriched
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048810:CoQ-deficiency_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_specific
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:AIA
      WBPaper00061340:AIB
      WBPaper00061340:AIM
      WBPaper00061340:AIN
      WBPaper00061340:AIN_parent
      WBPaper00061340:AIY
      WBPaper00061340:ALA
      WBPaper00061340:AVL
      WBPaper00061340:AWC
      WBPaper00061340:DVC_parent
      WBPaper00061340:g2_parent
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:M4_parent
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061340:Parents_of_Y_DA6_DA7_DA9
      WBPaper00061340:Parent_of_K_Kprime
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:Parent_of_PVP_and_rect_V
      WBPaper00061340:PVT
      WBPaper00061340:RIC
      WBPaper00061340:RIS
      WBPaper00061340:RME
      WBPaper00061340:RME_LR_parent
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:ccg-1_12351-ZC410.5
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061651:ADA_enriched
      WBPaper00061651:ADE_enriched
      WBPaper00061651:AIA_enriched
      WBPaper00061651:AIB_enriched
      WBPaper00061651:AIM_enriched
      WBPaper00061651:AIN_enriched
      WBPaper00061651:AIY_enriched
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:ALA_enriched
      WBPaper00061651:AQR_enriched
      WBPaper00061651:ASG_enriched
      WBPaper00061651:AUA_enriched
      WBPaper00061651:AVL_enriched
      WBPaper00061651:AVM_enriched
      WBPaper00061651:BAG_enriched
      WBPaper00061651:Distal_tip_cell_enriched
      WBPaper00061651:DVA_enriched
      WBPaper00061651:DVB_enriched
      WBPaper00061651:DVC_enriched
      WBPaper00061651:HSN_enriched
      WBPaper00061651:I4_enriched
      WBPaper00061651:I5_enriched
      WBPaper00061651:I6_enriched
      WBPaper00061651:IL2_DV_enriched
      WBPaper00061651:IL2_LR_enriched
      WBPaper00061651:LUA_enriched
      WBPaper00061651:M1_enriched
      WBPaper00061651:MI_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:PHB_enriched
      WBPaper00061651:PHC_enriched
      WBPaper00061651:PLN_enriched
      WBPaper00061651:PVM_enriched
      WBPaper00061651:RIB_enriched
      WBPaper00061651:RIC_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:RIF_enriched
      WBPaper00061651:RIG_enriched
      WBPaper00061651:RIH_enriched
      WBPaper00061651:RIP_enriched
      WBPaper00061651:RIS_enriched
      WBPaper00061651:RIV_enriched
      WBPaper00061651:RMD_LR_enriched
      WBPaper00061651:RMG_enriched
      WBPaper00061651:RMH_enriched
      WBPaper00061651:SDQ_enriched
      WBPaper00061651:SMD_enriched
      WBPaper00061651:URA_enriched
      WBPaper00061651:URB_enriched
      WBPaper00061651:URX_enriched
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-3(bn199)_downregulated_EGCs
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065623:82
      WBPaper00065623:100
      WBPaper00065623:133
      WBPaper00065623:145
      WBPaper00065623:165
      WBPaper00065841:28_0
      WBPaper00065841:74_0
      WBPaper00065841:97_0
      WBPaper00065841:107_0
      WBPaper00065841:108_0
      WBPaper00065841:121_0
      WBPaper00065841:124_0
      WBPaper00065841:134_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_13
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_187
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032948:StarveUp3
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036286:Pattern_I
      WBPaper00037695:LD_3-day
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040876:mir-35_upregulated
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
    Interaction: WBInteraction000050026
      WBInteraction000136794
      WBInteraction000138054
      WBInteraction000203424
      WBInteraction000211565
      WBInteraction000225334
      WBInteraction000226164
      WBInteraction000252363
      WBInteraction000259761
      WBInteraction000272436
      WBInteraction000283055
      WBInteraction000297727
      WBInteraction000305970
      WBInteraction000318739
      WBInteraction000324691
      WBInteraction000353548
      WBInteraction000356903
      WBInteraction000368055
      WBInteraction000379563
      WBInteraction000386242
      WBInteraction000392960
      WBInteraction000395191
      WBInteraction000398700
      WBInteraction000405514
      WBInteraction000413365
      WBInteraction000541378
      WBInteraction000547347
      WBInteraction000556405
      WBInteraction000575334
      WBInteraction000575831
      WBInteraction000579871
  Map_info: Map: X Position: 7.00899 Error: 0.003434
    Positive: Positive_clone: C23H4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4173
        4210
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene