WormBase Tree Display for Gene: WBGene00000216

WBGene00000216 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: H22K11
  Identity: Version: 1
    Name: CGC_name: asp-3 Person_evidence: WBPerson184
      Sequence_name: H22K11.1
      Molecular_name: H22K11.1
        H22K11.1.1
        CE47856
      Other_name: CELE_H22K11.1 Accession_evidence: NDB BX284606
      Public_name: asp-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: asp
    Allele (35)
    Strain: WBStrain00051696
      WBStrain00055639
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (36)
    Paralog (17)
    Structured_description: Concise_description: asp-3 encodes an aspartyl protease homolog that is required, in parallel with ASP-4 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). Paper_evidence: WBPaper00005513
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable aspartic-type endopeptidase activity. Involved in programmed necrotic cell death. Located in lysosome. Expressed in intestine and uterus. Is an ortholog of human NAPSA (napsin A aspartic peptidase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: H22K11.1
    Corresponding_transcript: H22K11.1.1
    Other_sequence (229)
    Associated_feature: WBsf662316
      WBsf662911
      WBsf982190
      WBsf1005643
      WBsf1005644
      WBsf1023141
      WBsf235869
      WBsf235870
      WBsf235871
  Experimental_info: RNAi_result (20)
    Expr_pattern: Expr2132
      Expr1020339
      Expr1030133
      Expr1153183
      Expr2009467
      Expr2027705
    Drives_construct: WBCnstr00037656
    Construct_product: WBCnstr00037656
    Antibody: WBAntibody00002873
    Microarray_results (25)
    Expression_cluster: WBPaper00028802:intestine_unique
      WBPaper00030922:glycosylated_protein
      WBPaper00032528:L3_enriched
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00046858:elt-2(RNAi)_upregulated
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048952:glucose_repressed
      WBPaper00048988:neuron_expressed
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049484:elt-2(RNAi)_downregulated_L1
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049920:hyl-2(tm2031)_upregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051039:intestine_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051461:pig-1(gm344)_downregulated
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053020:sta-1(ok587)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053814:15C_upregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00053814:OP50_vs_PY79_downregulated_PY79
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:gut-microbiota_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058665:graphene-oxide_upregulated_mRNA
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00060911:prx-5(RNAi)_upregulated_protein
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:F54D5.3_7003-F54D5.3_7004
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061651:ASI_enriched
      WBPaper00061651:Intestine_enriched
      WBPaper00061692:acivicin_downregulated
      WBPaper00061818:AFD_enriched_protein
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062056:lin-35(n745)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:hsf-1(RNAi)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062518:atf-4_regulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_upregulated_protein
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064933:L1_secret_protein
      WBPaper00064952:Day10_vs_Day1_downregulated_25C
      WBPaper00064952:Day10_vs_L4_downregulated_20C
      WBPaper00064952:Day10_vs_L4_downregulated_25C
      WBPaper00065029:cadmium_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:JU1400_N.ironsii_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065392:Lb.gasseri_downregulated
      WBPaper00065623:5
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:3_0
      WBPaper00065841:3_1
      WBPaper00065841:3_2
      WBPaper00065841:3_4
      WBPaper00065841:30_3
      WBPaper00065841:77_0
      WBPaper00065841:102_0
      WBPaper00065877:rege-1(imm070)_upregulated_OP50
      WBPaper00065877:rege-1(imm070)_upregulated_PA14
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_1_3
      cgc4489_group_25
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035892:Y.pestis_regulated
      WBPaper00036286:Pattern_C
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040876:mir-35_downregulated
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00044091:Bpseudomallei_regulated_qPCR-confirmed
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00044535:male_downregulated
      WBPaper00048567:dnj-14_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc5976]:class_1
    Interaction: WBInteraction000029757
      WBInteraction000103219
      WBInteraction000104706
      WBInteraction000108850
      WBInteraction000116235
      WBInteraction000119663
      WBInteraction000127548
      WBInteraction000135495
      WBInteraction000135508
      WBInteraction000140825
      WBInteraction000140826
      WBInteraction000149155
      WBInteraction000150429
      WBInteraction000151647
      WBInteraction000163791
      WBInteraction000170294
      WBInteraction000172120
      WBInteraction000175662
      WBInteraction000175674
      WBInteraction000176566
      WBInteraction000187550
      WBInteraction000188510
      WBInteraction000190421
      WBInteraction000194445
      WBInteraction000200080
      WBInteraction000201091
      WBInteraction000203031
      WBInteraction000206212
      WBInteraction000212033
      WBInteraction000212400
      WBInteraction000212838
      WBInteraction000213431
      WBInteraction000217862
      WBInteraction000218578
      WBInteraction000229275
      WBInteraction000230237
      WBInteraction000230419
      WBInteraction000235558
      WBInteraction000237237
      WBInteraction000247250
      WBInteraction000251784
      WBInteraction000255365
      WBInteraction000261055
      WBInteraction000266516
      WBInteraction000266920
      WBInteraction000268162
      WBInteraction000270129
      WBInteraction000273832
      WBInteraction000275996
      WBInteraction000277032
      WBInteraction000290857
      WBInteraction000292271
      WBInteraction000292501
      WBInteraction000293272
      WBInteraction000295595
      WBInteraction000296750
      WBInteraction000298406
      WBInteraction000299860
      WBInteraction000303529
      WBInteraction000304202
      WBInteraction000304910
      WBInteraction000308354
      WBInteraction000310591
      WBInteraction000312207
      WBInteraction000312983
      WBInteraction000316220
      WBInteraction000319791
      WBInteraction000321831
      WBInteraction000324220
      WBInteraction000335249
      WBInteraction000337228
      WBInteraction000342701
      WBInteraction000348796
      WBInteraction000350508
      WBInteraction000351059
      WBInteraction000352797
      WBInteraction000364911
      WBInteraction000368903
      WBInteraction000369523
      WBInteraction000375765
      WBInteraction000375984
      WBInteraction000379230
      WBInteraction000380398
      WBInteraction000380905
      WBInteraction000384127
      WBInteraction000386804
      WBInteraction000393482
      WBInteraction000394404
      WBInteraction000402500
      WBInteraction000404968
      WBInteraction000405781
      WBInteraction000406220
      WBInteraction000409380
      WBInteraction000412975
      WBInteraction000416168
      WBInteraction000416826
      WBInteraction000418625
      WBInteraction000418955
      WBInteraction000419268
      WBInteraction000421264
      WBInteraction000421439
      WBInteraction000421482
      WBInteraction000423060
      WBInteraction000424415
      WBInteraction000425371
      WBInteraction000431440
      WBInteraction000444165
      WBInteraction000447970
      WBInteraction000451218
      WBInteraction000452101
      WBInteraction000457932
      WBInteraction000461949
      WBInteraction000465537
      WBInteraction000473337
      WBInteraction000473338
      WBInteraction000500642
      WBInteraction000500990
      WBInteraction000520149
      WBInteraction000542657
      WBInteraction000542660
      WBInteraction000546299
      WBInteraction000546779
      WBInteraction000553138
      WBInteraction000554480
      WBInteraction000555059
      WBInteraction000560168
      WBInteraction000562997
      WBInteraction000571519
      WBInteraction000577488
      WBInteraction000579534
      WBInteraction000582896
  Map_info: Map: X Position: -2.42178 Error: 0.004086
    Positive: Positive_clone: H22K11 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (29)
  Remark: Sequence connection from [Freedman J]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene