| WBGene00006791 | SMap | S_parent | Sequence | T04D1 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-57 | Person_evidence | WBPerson261 |
| | | Sequence_name | T04D1.3 |
| | | Molecular_name (12) |
| | | Other_name | CELE_T04D1.3 | Accession_evidence | NDB | BX284601 |
| | | Public_name | unc-57 |
| | DB_info | Database | WormQTL | gene | WBGene00006791 |
| | | | WormFlux | gene | WBGene00006791 |
| | | | NDB | locus_tag | CELE_T04D1.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006791|UniProtKB=B1V8A0 |
| | | | | family | PTHR14167 |
| | | | NCBI | gene | 172078 |
| | | | RefSeq | protein | NM_001047215.5 |
| | | | | | NM_001129041.3 |
| | | | | | NM_001129040.5 |
| | | | | | NM_001047216.3 |
| | | | SwissProt | UniProtAcc | B1V8A0 |
| | | | TREEFAM | TREEFAM_ID | TF313281 |
| | | | UniProt_GCRP | UniProtAcc | B1V8A0 |
| | | | OMIM | gene | 601768 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143185 |
| | Allele (61) |
| | Legacy_information | e406 : strong kinker active small and thin; slow pharyngeal pumping; tends to hypercontract. ES3 ME2. NA4 (e590 e957 etc.). |
| | | [C.elegansII] e406 : strong kinker, active; small and thin; slow pharyngeal pumping; tends to hypercontract. ES3 ME2. OA>5: e590.e957, e1190, st199, ad592 etc. [Brenner 1974; Avery 1993; DA] |
| | Strain | WBStrain00001793 |
| | | WBStrain00003424 |
| | | WBStrain00004265 |
| | | WBStrain00004163 |
| | | WBStrain00005501 |
| | | WBStrain00006676 |
| | RNASeq_FPKM (74) |
| | GO_annotation (16) |
| | Contained_in_operon | CEOP1200 |
| | Ortholog (46) |
| | Paralog | WBGene00001335 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | | WBGene00012891 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00015128 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | unc-57 encodes an ortholog of endophilin A that is required for synaptic vesicle endocytosis; UNC-57 is expressed in all neurons, at synapses and neuromuscular junctions, and (weakly) in the spermetheca; like other endophilins, UNC-57 has a large BAR domain, an N-terminal coiled-coil domain within the BAR domain, and a C-terminal SH3 domain; UNC-57 protein is necessary for proper localization of UNC-26 (synaptojanin) protein, which in turn is needed for endocytosis; unc-57 and unc-26 mutants are morphologically, ultrastructurally, and electrophysiologically similar both to one another and to double mutants, indicating that UNC-57 and UNC-26 act in a single genetic pathway. | Paper_evidence | WBPaper00006213 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Involved in clathrin-dependent endocytosis and necroptotic process. Located in neuromuscular junction. Expressed in several structures, including coelomocyte; head; hermaphrodite gonad; intestine; and muscle cell. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Is an ortholog of human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2); SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1); and SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:3070 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10830) |
| | | DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10830) |
| Molecular_info | Corresponding_CDS | T04D1.3a |
| | | T04D1.3b |
| | | T04D1.3c |
| | | T04D1.3d |
| | Corresponding_CDS_history | T04D1.3:wp102 |
| | | T04D1.3:wp126 |
| | | T04D1.3:wp154 |
| | Corresponding_transcript | T04D1.3a.1 |
| | | T04D1.3b.1 |
| | | T04D1.3c.1 |
| | | T04D1.3d.1 |
| | Other_sequence (55) |
| | Associated_feature | WBsf656242 |
| | | WBsf983464 |
| | | WBsf1009694 |
| | | WBsf217561 |
| | | WBsf217562 |
| | | WBsf217563 |
| | | WBsf217564 |
| Experimental_info | RNAi_result | WBRNAi00052386 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089735 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00035136 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00083269 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090002 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00098495 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090161 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090320 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00001618 |
| | | WBCnstr00001619 |
| | | WBCnstr00001621 |
| | | WBCnstr00001636 |
| | | WBCnstr00004249 |
| | | WBCnstr00022517 |
| | | WBCnstr00034147 |
| | Construct_product (16) |
| | Antibody | WBAntibody00002626 |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00029359_1166 |
| | | WBPaper00029359_1194 |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1240 |
| | | WBPaper00029359_1243 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1336 |
| | | WBPaper00029359_1546 |
| | | WBPaper00029359_1549 |
| | | WBPaper00029359_1557 |
| | | WBPaper00029359_1599 |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049159:Microwave_upregulated_adult |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053039:Aspirin_upregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059334:SACY-1_interacting |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:SIA |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061527:lst-4_22151-F46F11.6_12556 |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064992:Capsaicin_downregulated |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065841:68_1 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_1 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-exposed_3h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_1 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(41_min) |
| | | [cgc5767]:expression_class_MD_pd(53_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | Interaction (123) |
| Map_info | Map | I | Position | -1.01724 | Error | 0.009779 |
| | Well_ordered |
| | Positive | Positive_clone | T04D1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data (3) |
| | Landmark_gene |
| Reference (48) |
| Method | Gene |
