WBGene00006784 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | T21C12 |
| Identity | Version | 1 |
| | Name | CGC_name | unc-49 | Person_evidence | WBPerson261 |
| | | Sequence_name | T21C12.1 |
| | | Molecular_name (40) |
| | | Other_name | unc-49A | Accession_evidence | EMBL | AF151640 |
| | | | unc-49B | Accession_evidence | EMBL | AF151641 |
| | | | unc-49C | Accession_evidence | EMBL | AF151644 |
| | | | CELE_T21C12.1 | Accession_evidence | NDB | BX284603 |
| | | Public_name | unc-49 |
| | DB_info | Database | AceView | gene | 3L621 |
| | | | WormQTL | gene | WBGene00006784 |
| | | | WormFlux | gene | WBGene00006784 |
| | | | NDB | locus_tag | CELE_T21C12.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006784|UniProtKB=G5ECD3 |
| | | | | family | PTHR18945 |
| | | | NCBI | gene | 176472 |
| | | | RefSeq | protein (13) |
| | | | TrEMBL | UniProtAcc (13) |
| | | | UniProt_GCRP | UniProtAcc | G5ECD3 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143164 |
| | Allele (220) |
| | Legacy_information | e382 : shrinker contracts both dorsally and ventrally when prodded slow poor backing slightly small. ES3 ME2. NA6 (e407 e468). |
| | | See also e641, n1324 |
| | | [C.elegansII] e382 : shrinker, contracts both dorsally and ventrally when prodded; slow; poor backing, slightly small. Probable defect in inhibitory GABA receptor function. ES3 ME2. OA>5: e407, e468, e929, n1324 etc. Cloned: encodes predicted GABA-A receptor. In probable operon with two other GABA receptor subunits. [Brenner 1974; McIntire et al. 1993; EG; MT] |
| | Strain (14) |
| | Component_of_genotype | WBGenotype00000119 |
| | RNASeq_FPKM (74) |
| | GO_annotation (28) |
| | Ortholog (37) |
| | Paralog (100) |
| | Structured_description | Concise_description | unc-49 encodes multiple subunits of a heteromeric GABA receptor; unc-49 activity is required for postsynaptic GABA responsiveness and thus for normal regulation of locomotion; UNC-49::GFP reporter fusions for at least two isoforms are expressed in dorsal and ventral head and body wall muscles, with isoform-specific expression also seen in the sphincter muscle; UNC-49::GFP subcellular localization is most prominent at neuromuscular junctions; in Xenopus oocytes and mammalian tissue culture cells, two UNC-49 subunits, UNC-49B and UNC-49C, are able to form a functional heteromeric GABA receptor. | Paper_evidence | WBPaper00003576 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 24 Aug 2007 00:00:00 |
| | | Automated_description | Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00060194 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 18 May 2022 00:00:00 |
| Models_disease_asserted | WBDOannot00001202 |
| | WBDOannot00001203 |
| Molecular_info | Corresponding_CDS (13) |
| | Corresponding_CDS_history | T21C12.1a:wp227 |
| | | T21C12.1a:wp239 |
| | | T21C12.1g:wp275 |
| | Corresponding_transcript (14) |
| | Other_sequence (51) |
| | Associated_feature (25) |
| Experimental_info | RNAi_result (10) |
| | Expr_pattern | Expr1283 |
| | | Expr15907 |
| | | Expr1027570 |
| | | Expr1032855 |
| | | Expr1157259 |
| | | Expr1200291 |
| | | Expr2017881 |
| | | Expr2036017 |
| | | Marker2 |
| | | Marker19 |
| | Drives_construct | WBCnstr00001626 |
| | | WBCnstr00001627 |
| | | WBCnstr00006881 |
| | | WBCnstr00010191 |
| | | WBCnstr00019381 |
| | | WBCnstr00020581 |
| | | WBCnstr00034153 |
| | | WBCnstr00042588 |
| | Construct_product | WBCnstr00001627 |
| | | WBCnstr00006881 |
| | | WBCnstr00016180 |
| | | WBCnstr00019381 |
| | | WBCnstr00020010 |
| | | WBCnstr00020581 |
| | | WBCnstr00021428 |
| | | WBCnstr00034153 |
| | Antibody | WBAntibody00000613 |
| | | WBAntibody00001987 |
| | Microarray_results (88) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037946:EGL-5_interacting |
| | | WBPaper00038061:aldicarb_downregulated |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044037:eat-2_regulated_nhr-62_dependent |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(gk119)_upregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00045861:ash-2(tm1095)_upregulated |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:alovudine_72h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated |
| | | WBPaper00056586:kri-1(ok1251)_downregulated |
| | | WBPaper00056586:mpk-2(ok219)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059754:P.aeruginosa_PA14_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061466:nath-10(icb99)_upregulated |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:176662_at-Y53F4B.16 |
| | | WBPaper00061527:myo-3-Y71G12B.11_22540 |
| | | WBPaper00061527:syd-1_2945-unc-41_2170 |
| | | WBPaper00061651:MI_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:etr-1(lq61)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:4_0 |
| | | WBPaper00065841:6_0 |
| | | WBPaper00065841:6_2 |
| | | WBPaper00065841:10_0 |
| | | WBPaper00065841:38_2 |
| | | WBPaper00065841:51_0 |
| | | WBPaper00065841:51_1 |
| | | WBPaper00065841:76_0 |
| | | WBPaper00065841:98_0 |
| | | WBPaper00065841:102_0 |
| | | WBPaper00065841:103_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:133_0 |
| | | WBPaper00065841:136_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4386_cluster_3_3 |
| | | cgc4489_group_20 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040963:TA300_up |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042236:flcn-1(ok975)_upregulated |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | WBPaper00047070:N2_UV_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_A |
| | Interaction (31) |
| | WBProcess | WBbiopr:00000010 |
| Map_info | Map | III | Position | 3.35021 | Error | 0.089636 |
| | Well_ordered |
| | Positive | Inside_rearr | nDf40 |
| | | | mT1 |
| | | Positive_clone | T21C12 | Person_evidence | WBPerson39 |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 73 |
| | | | 86 |
| | | | 589 |
| | | | 3249 |
| | | Multi_point (55) |
| | | Pos_neg_data | 3242 |
| | | | 3250 |
| | | | 3251 |
| Reference (138) |
| Remark | Sequence connection from [Bamber BA] |
| Method | Gene |