cyn-5 encodes a cyclophilin that is functional in vitro and is predicted to be a secreted protein that is structurally most similar to human cyclophilin B; expressed in the intestine.
Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in cytoplasm. Expressed in intestine. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 9. Is an ortholog of human PPIB (peptidylprolyl isomerase B).
[Page AM] Is transpliced by SL-1. Isolated from mixed stage cDNA by using SL1, and known 3' seq from CEESH33F. Hybridises to YACs Y62C9, and by PCR and Southerns to cosmid B0467.
cDNAs CEMSA21F,CEMSA21R,CEMSH33F,CEMSH33R represent this gene. They have been taken out of the moleculat information above. [sdm 11/2000]
PPIase or cyclophilin, EC 5.2.1.8
This gene has been renamed with approval of the CGC (cyp-5->cyn-5)
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.