WBGene00002974 | SMap | S_parent | Sequence | F58D2 |
| Identity | Version | 1 |
| | Name | CGC_name | lev-1 | Person_evidence | WBPerson368 |
| | | Sequence_name | F09E8.7 |
| | | Molecular_name | F09E8.7a |
| | | | F09E8.7a.1 |
| | | | CE24888 |
| | | | F09E8.7b |
| | | | CE43918 |
| | | | F09E8.7b.1 |
| | | Other_name | acr-1 |
| | | | tmr-1 |
| | | | CELE_F09E8.7 | Accession_evidence | NDB | BX284604 |
| | | Public_name | lev-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lev |
| | Reference_allele | WBVar00143038 |
| | Allele (119) |
| | Legacy_information | e211 (pka tmr-1) : almost normal movement in absence of drug uncoordinated but not hypercontracted in 1 mM levamisole. ES2. ME3. NA > 10 (x22 etc.). Also two rare semidominant alleles with uncoordinated phenotype x21 : (uncoordinated Egl-c ME3) x63. |
| | | See also e211, e289 |
| | | [C.elegansII] e211 : (pka tmr-1) almost normal movement in absence of drug uncoordinated but not hypercontracted in 1 mM levamisole. ES2. ME3. OA>10: x22, e289, x577 etc. Also two rare semidominant alleles with uncoordinated phenotype, x21 (uncoordinated Egl-c, ME3), x63. Cloned: corresponds to acr-1, encoding subunit of nicotinic acetylcholine receptor. [Lewis et al. 1980, 1987; ZZ; MQ] |
| | Strain | WBStrain00003893 |
| | | WBStrain00030691 |
| | | WBStrain00033031 |
| | | WBStrain00040924 |
| | | WBStrain00000741 |
| | | WBStrain00004129 |
| | | WBStrain00004573 |
| | RNASeq_FPKM (74) |
| | GO_annotation (36) |
| | Ortholog (46) |
| | Paralog (100) |
| | Structured_description | Concise_description | lev-1 encodes a non-alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, regulation of egg-laying behavior, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3; a LEV-1::GFP fusion protein is expressed in all body wall muscle cells and a subset of ventral cord motor neurons. | Paper_evidence | WBPaper00000031 |
| | | | | | WBPaper00004660 |
| | | | | | WBPaper00005223 |
| | | | | | WBPaper00024530 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | | WBPerson1843 |
| | | | | Date_last_updated | 20 Jun 2008 00:00:00 |
| | | Automated_description | Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in regulation of egg-laying behavior; regulation of locomotion; and transmembrane transport. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase |
| | | | | Date_last_updated | 24 Apr 2024 00:00:00 |
| Disease_info | Potential_model | DOID:3905 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) |
| | | DOID:5409 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) |
| | | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) |
| | | DOID:3083 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) |
| | | DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) |
| | | DOID:0110663 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1955) |
| | | DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) |
| | | DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) |
| | | DOID:0050742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) |
| | | DOID:0110662 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1955) |
| Molecular_info | Corresponding_CDS | F09E8.7a |
| | | F09E8.7b |
| | Corresponding_transcript | F09E8.7a.1 |
| | | F09E8.7b.1 |
| | Other_sequence (14) |
| | Associated_feature | WBsf652327 |
| | | WBsf668451 |
| | | WBsf668452 |
| | | WBsf668453 |
| | | WBsf668454 |
| | | WBsf998352 |
| | | WBsf998353 |
| | | WBsf1018500 |
| | | WBsf231093 |
| Experimental_info | RNAi_result | WBRNAi00102763 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00012987 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00001574 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00066400 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00044139 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00066521 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr3395 |
| | | Expr3708 |
| | | Expr3709 |
| | | Expr4346 |
| | | Expr1027358 |
| | | Expr1031374 |
| | | Expr1148107 |
| | | Expr2013085 |
| | | Expr2031317 |
| | Drives_construct (12) |
| | Construct_product (14) |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00030922:glycosylated_protein |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_enriched |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00051257:Levamisole_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058725:sftb-1(cer39)_upregulated |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059728:20ug_cholesterol_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061040:eat-2(ad1116)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:RME |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:myo-3-Y71G12B.11_22540 |
| | | WBPaper00061651:RME_DV_enriched |
| | | WBPaper00061651:RME_LR_enriched |
| | | WBPaper00061823:mex-3(spr9)_downregulated |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065841:10_0 |
| | | WBPaper00065841:70_1 |
| | | WBPaper00065841:100_0 |
| | | WBPaper00065841:109_0 |
| | | WBPaper00065841:116_0 |
| | | WBPaper00065841:118_0 |
| | | WBPaper00065841:121_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4489_group_14 |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_2 |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:environmental_prime |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (25) |
| Map_info | Map | IV | Position | 8.43149 | Error | 0.004865 |
| | Well_ordered |
| | Positive | Inside_rearr | nDf27 |
| | | | nDf28 |
| | | | sDf21 |
| | | Positive_clone | F09E8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | JF#WA10 |
| | Mapping_data | 2_point | 228 |
| | | | 229 |
| | | | 347 |
| | | | 2726 |
| | | | 4660 |
| | | | 4661 |
| | | | 4666 |
| | | Multi_point (19) |
| | | Pos_neg_data (11) |
| Reference (112) |
| Method | Gene |