trx-1 encodes a thioredoxin, a small redox protein that functions as a protein-disulfide reductase; loss of trx-1 activity via a deletion mutation and RNAi indicates that trx-1 is required for normal adult lifespan; in vitro, TRX-1 is capable of reducing protein disulfide bonds in the presence of a mammalian thioredoxin reductase; a TRX-1::GFP fusion protein is expressed in the ASJL/R amphid chemosensory neurons in males and hermaphrodites beginning just prior to hatching and continuing through larval and adult stages, including the alternative dauer larval stage; expression is also variably detected in posterior intestinal cells in larvae and adults, but not in dauers; subcellularly, the TRX-1::GFP fusion protein is detected in the nucleus, cytoplasm, cilia, dendrites, and axons.
Enables protein-disulfide reductase activity. Involved in determination of adult lifespan. Located in several cellular components, including neuronal cell body; nucleus; and plasma membrane bounded cell projection. Expressed in ASJL; ASJR; head neurons; and in male.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.