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WormBase Tree Display for Gene: WBGene00000156

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Name Class

WBGene00000156SMapS_parentSequenceK04G2
IdentityVersion1
NameCGC_nameapr-1Person_evidenceWBPerson419
Sequence_nameK04G2.8
Molecular_nameK04G2.8a
K04G2.8a.1
CE06102
K04G2.8b
CE18016
K04G2.8c
CE51809
K04G2.8b.1
K04G2.8c.1
Other_nameAPCPaper_evidenceWBPaper00044307
CELE_K04G2.8Accession_evidenceNDBBX284601
Public_nameapr-1
DB_infoDatabaseAceViewgene1I631
WormQTLgeneWBGene00000156
SignaLinkproteinWBGene00000156
WormFluxgeneWBGene00000156
NDBlocus_tagCELE_K04G2.8
PanthergeneCAEEL|WormBase=WBGene00000156|UniProtKB=Q21227
familyPTHR12607
NCBIgene172591
RefSeqproteinNM_059816.7
NM_001347280.1
NM_001026376.6
SwissProtUniProtAccQ21227
TREEFAMTREEFAM_IDTF106496
TrEMBLUniProtAccA0A1I6CM53
UniProt_GCRPUniProtAccQ21227
OMIMgene611731
612034
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classapr
Allele (69)
Possibly_affected_byWBVar02153202
Legacy_information[Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01]
StrainWBStrain00037280
WBStrain00000140
WBStrain00008585
WBStrain00024309
RNASeq_FPKM (74)
GO_annotation (77)
Ortholog (41)
Structured_descriptionConcise_descriptionThe apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway.Paper_evidence (12)
Curator_confirmedWBPerson324
WBPerson567
Date_last_updated25 May 2011 00:00:00
Automated_descriptionEnables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (20)
Molecular_infoCorresponding_CDSK04G2.8a
K04G2.8b
K04G2.8c
Corresponding_transcriptK04G2.8a.1
K04G2.8b.1
K04G2.8c.1
Other_sequenceAF013950
CGC00612_1
ACC25655_1
EX555243.1
CBC06635_1
Associated_featureWBsf656598
WBsf218114
Experimental_infoRNAi_resultWBRNAi00101650Inferred_automaticallyRNAi_primary
WBRNAi00101537Inferred_automaticallyRNAi_primary
WBRNAi00062614Inferred_automaticallyRNAi_primary
WBRNAi00091594Inferred_automaticallyRNAi_primary
WBRNAi00099035Inferred_automaticallyRNAi_primary
WBRNAi00101533Inferred_automaticallyRNAi_primary
WBRNAi00101666Inferred_automaticallyRNAi_primary
WBRNAi00091593Inferred_automaticallyRNAi_primary
WBRNAi00099029Inferred_automaticallyRNAi_primary
WBRNAi00101535Inferred_automaticallyRNAi_primary
WBRNAi00099037Inferred_automaticallyRNAi_primary
WBRNAi00077089Inferred_automaticallyRNAi_primary
WBRNAi00112568Inferred_automaticallyRNAi_primary
WBRNAi00025870Inferred_automaticallyRNAi_primary
WBRNAi00101610Inferred_automaticallyRNAi_primary
WBRNAi00062622Inferred_automaticallyRNAi_primary
WBRNAi00098844Inferred_automaticallyRNAi_primary
WBRNAi00091596Inferred_automaticallyRNAi_primary
WBRNAi00101358Inferred_automaticallyRNAi_primary
WBRNAi00101857Inferred_automaticallyRNAi_primary
WBRNAi00022931Inferred_automaticallyRNAi_primary
WBRNAi00062631Inferred_automaticallyRNAi_primary
WBRNAi00098802Inferred_automaticallyRNAi_primary
WBRNAi00099036Inferred_automaticallyRNAi_primary
WBRNAi00098925Inferred_automaticallyRNAi_primary
WBRNAi00092551Inferred_automaticallyRNAi_primary
WBRNAi00068826Inferred_automaticallyRNAi_primary
WBRNAi00099040Inferred_automaticallyRNAi_primary
WBRNAi00084512Inferred_automaticallyRNAi_primary
WBRNAi00101630Inferred_automaticallyRNAi_primary
WBRNAi00091565Inferred_automaticallyRNAi_primary
WBRNAi00099005Inferred_automaticallyRNAi_primary
WBRNAi00061053Inferred_automaticallyRNAi_primary
WBRNAi00091598Inferred_automaticallyRNAi_primary
WBRNAi00003922Inferred_automaticallyRNAi_primary
WBRNAi00098815Inferred_automaticallyRNAi_primary
WBRNAi00068307Inferred_automaticallyRNAi_primary
WBRNAi00110439Inferred_automaticallyRNAi_primary
WBRNAi00070927Inferred_automaticallyRNAi_primary
WBRNAi00062618Inferred_automaticallyRNAi_primary
WBRNAi00091588Inferred_automaticallyRNAi_primary
WBRNAi00077086Inferred_automaticallyRNAi_primary
WBRNAi00022930Inferred_automaticallyRNAi_primary
WBRNAi00099031Inferred_automaticallyRNAi_primary
WBRNAi00091584Inferred_automaticallyRNAi_primary
WBRNAi00001890Inferred_automaticallyRNAi_primary
WBRNAi00092772Inferred_automaticallyRNAi_primary
WBRNAi00101668Inferred_automaticallyRNAi_primary
WBRNAi00101640Inferred_automaticallyRNAi_primary
WBRNAi00068229Inferred_automaticallyRNAi_primary
WBRNAi00062621Inferred_automaticallyRNAi_primary
WBRNAi00025869Inferred_automaticallyRNAi_primary
WBRNAi00101468Inferred_automaticallyRNAi_primary
WBRNAi00070925Inferred_automaticallyRNAi_primary
WBRNAi00101853Inferred_automaticallyRNAi_primary
WBRNAi00101676Inferred_automaticallyRNAi_primary
WBRNAi00068306Inferred_automaticallyRNAi_primary
WBRNAi00084511Inferred_automaticallyRNAi_primary
WBRNAi00077088Inferred_automaticallyRNAi_primary
WBRNAi00111668Inferred_automaticallyRNAi_primary
WBRNAi00101660Inferred_automaticallyRNAi_primary
WBRNAi00101815Inferred_automaticallyRNAi_primary
WBRNAi00077305Inferred_automaticallyRNAi_primary
WBRNAi00061056Inferred_automaticallyRNAi_primary
WBRNAi00022928Inferred_automaticallyRNAi_primary
WBRNAi00092550Inferred_automaticallyRNAi_primary
WBRNAi00101709Inferred_automaticallyRNAi_primary
WBRNAi00068308Inferred_automaticallyRNAi_primary
WBRNAi00101814Inferred_automaticallyRNAi_primary
WBRNAi00068305Inferred_automaticallyRNAi_primary
WBRNAi00101625Inferred_automaticallyRNAi_primary
WBRNAi00101530Inferred_automaticallyRNAi_primary
WBRNAi00064700Inferred_automaticallyRNAi_primary
WBRNAi00068304Inferred_automaticallyRNAi_primary
WBRNAi00098982Inferred_automaticallyRNAi_primary
WBRNAi00101539Inferred_automaticallyRNAi_primary
WBRNAi00077090Inferred_automaticallyRNAi_primary
WBRNAi00101508Inferred_automaticallyRNAi_primary
WBRNAi00101600Inferred_automaticallyRNAi_primary
WBRNAi00091595Inferred_automaticallyRNAi_primary
WBRNAi00091580Inferred_automaticallyRNAi_primary
WBRNAi00077087Inferred_automaticallyRNAi_primary
WBRNAi00099041Inferred_automaticallyRNAi_primary
WBRNAi00098848Inferred_automaticallyRNAi_primary
WBRNAi00077292Inferred_automaticallyRNAi_primary
WBRNAi00064496Inferred_automaticallyRNAi_primary
WBRNAi00098980Inferred_automaticallyRNAi_primary
WBRNAi00084510Inferred_automaticallyRNAi_primary
WBRNAi00098846Inferred_automaticallyRNAi_primary
WBRNAi00098981Inferred_automaticallyRNAi_primary
WBRNAi00062617Inferred_automaticallyRNAi_primary
WBRNAi00091592Inferred_automaticallyRNAi_primary
WBRNAi00033968Inferred_automaticallyRNAi_primary
WBRNAi00091581Inferred_automaticallyRNAi_primary
WBRNAi00101465Inferred_automaticallyRNAi_primary
WBRNAi00098801Inferred_automaticallyRNAi_primary
WBRNAi00098995Inferred_automaticallyRNAi_primary
WBRNAi00101663Inferred_automaticallyRNAi_primary
WBRNAi00099004Inferred_automaticallyRNAi_primary
WBRNAi00070928Inferred_automaticallyRNAi_primary
WBRNAi00098425Inferred_automaticallyRNAi_primary
WBRNAi00101518Inferred_automaticallyRNAi_primary
WBRNAi00022929Inferred_automaticallyRNAi_primary
WBRNAi00049941Inferred_automaticallyRNAi_primary
Expr_patternExpr1046
Expr4600
Expr12119
Expr12448
Expr15118
Expr1028112
Expr1030085
Expr1153646
Expr2009365
Expr2027601
Drives_constructWBCnstr00005188
WBCnstr00007256
WBCnstr00009075
WBCnstr00009116
WBCnstr00012108
WBCnstr00016098
WBCnstr00020198
WBCnstr00021087
WBCnstr00037698
Construct_productWBCnstr00000526
WBCnstr00007257
WBCnstr00007258
WBCnstr00009057
WBCnstr00009075
WBCnstr00012108
WBCnstr00016098
WBCnstr00020198
WBCnstr00021087
WBCnstr00037698
AntibodyWBAntibody00000276
WBAntibody00000277
Microarray_results (25)
Expression_cluster (124)
Interaction (179)
WBProcessWBbiopr:00000073
Map_infoMapIPosition2.43771Error0.002342
PositivePositive_cloneK04G2Person_evidenceWBPerson524
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4159
4893
5616
Pseudo_map_position
Reference (108)
PictureWBPicture0000013084
Remark (2)
MethodGene