WormBase Tree Display for Gene: WBGene00000100

WBGene00000100 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 3
    Name: CGC_name: ajm-1 Person_evidence: WBPerson240
      Sequence_name: C25A11.4
      Molecular_name (42)
      Other_name: jam-1
        H08J11.c Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        H08J11.a
        H08J11.b
        CELE_C25A11.4 Accession_evidence: NDB BX284606
      Public_name: ajm-1
    DB_info: Database (10)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 01 Jul 2016 14:56:15 WBPerson1983 Event: Acquires_merge: WBGene00044785
        3 01 Jul 2016 14:56:15 WBPerson1983 Event: Acquires_merge: WBGene00019173
      Acquires_merge: WBGene00044785
        WBGene00019173
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ajm
    Allele (507)
    Legacy_information: [Raich WB, Hardin JD] No mutants known. Encodes protein recognized by monoclonal antibody MH27, associated with apical cell-cell junctions. Predicted gene C25A11.4 + C25A11.3
    Strain (22)
    RNASeq_FPKM (74)
    GO_annotation (24)
    Ortholog (27)
    Structured_description: Concise_description: ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo; AJM-1 contains a coiled-coil motif; AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo; AJM-1 is mislocalized in a dlg-1(RNAi) background; LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia; CLC-1 colocalizes with AJM-1; vab-9 mutations enhance the adhesion defects of ajm-1 mutants; ajm-1 is expressed at the apical borders of all epithelia. Paper_evidence: WBPaper00004765
            WBPaper00004961
            WBPaper00005194
            WBPaper00005946
            WBPaper00005969
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cytoskeletal protein binding activity. Involved in cell-cell junction organization and embryo development. Located in apicolateral plasma membrane; cell-cell junction; and plasma membrane bounded cell projection. Expressed in several structures, including arcade cell and epithelial cell. Is an ortholog of human AJM1 (apical junction component 1 homolog). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS (13)
    Corresponding_CDS_history: C25A11.4b:wp254
      C25A11.4c:wp254
      C25A11.4d:wp254
      C25A11.4e:wp254
    Corresponding_transcript (16)
    Other_sequence (84)
    Associated_feature: WBsf648396
      WBsf648398
      WBsf662327
      WBsf662377
      WBsf662378
      WBsf663078
      WBsf663079
      WBsf663080
      WBsf663081
      WBsf663082
      WBsf663083
      WBsf663084
      WBsf663085
      WBsf663086
      WBsf663087
      WBsf663088
      WBsf663089
      WBsf663090
      WBsf663091
      WBsf663092
      WBsf663093
      WBsf663094
      WBsf663095
      WBsf663096
      WBsf663097
      WBsf663098
      WBsf663099
      WBsf663100
      WBsf663101
      WBsf663102
      WBsf663103
      WBsf663104
      WBsf663105
      WBsf663106
      WBsf663107
      WBsf718664
      WBsf718665
      WBsf1006311
      WBsf1006312
      WBsf1006313
      WBsf1006314
      WBsf1006315
      WBsf1006316
      WBsf1006317
      WBsf1006318
      WBsf1006319
      WBsf1006320
      WBsf1006321
      WBsf1006322
      WBsf1006323
      WBsf1006324
      WBsf1006325
      WBsf1006326
      WBsf1006327
      WBsf1006328
      WBsf1006329
      WBsf1006330
      WBsf1006331
      WBsf1006332
      WBsf1006333
      WBsf1006334
      WBsf1006335
      WBsf1023499
      WBsf1023500
      WBsf1023501
      WBsf1023502
      WBsf1023503
      WBsf1023504
      WBsf1023505
      WBsf1023506
      WBsf1023507
      WBsf236122
      WBsf236123
      WBsf236124
      WBsf236125
      WBsf236126
  Experimental_info: RNAi_result (26)
    Expr_pattern (20)
    Drives_construct (23)
    Construct_product (11)
    Antibody: WBAntibody00000055
      WBAntibody00001322
    Microarray_results (94)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00024505:pharyngeal_enriched
      WBPaper00029359_1166
      WBPaper00029359_1197
      WBPaper00029359_1243
      WBPaper00029359_1291
      WBPaper00029359_1336
      WBPaper00029359_1546
      WBPaper00029359_1549
      WBPaper00029359_1557
      WBPaper00029359_1599
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_embryo_enriched
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
      WBPaper00044246:pgrn-1_ced-1_downregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00044786:lem-2(tm1582)_upregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046121:ecdoderm_unique
      WBPaper00046887:WNT-target
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049482:P.mirabilis_48h_regulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050636:aging_regulated_insoluble_protein
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_enriched
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00053888:drh-3(rrr2)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055013:HMG-4_interacting_protein
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:gut-microbiota_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056855:his-72(uge40)_downregulated
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:IL1_parent
      WBPaper00061340:ILso
      WBPaper00061340:mc1
      WBPaper00061340:mc2
      WBPaper00061340:mc3
      WBPaper00061340:NSM_parent
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:pm1_pm2
      WBPaper00061340:pm6
      WBPaper00061340:pm7
      WBPaper00061340:pm8
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061377:PAN-1_interacting
      WBPaper00061527:176662_at-Y53F4B.16
      WBPaper00061527:hlh-30_18579-unc-43_21739
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:npp-8_4355-afd-1_4796
      WBPaper00061527:sre-33-ZK1025.1_8337
      WBPaper00061527:Y37D8A.16-F54D1.6_15313
      WBPaper00061651:I3_enriched
      WBPaper00061651:M2_enriched
      WBPaper00061651:NSM_enriched
      WBPaper00061651:Spermatheca_enriched
      WBPaper00061818:ELKS-1_interacting
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064122:vulva_transcriptome
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064789:Day12_vs_Day1_upregulated_neuron
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065029:cadmium_upregulated
      WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065841:9_0
      WBPaper00065841:11_2
      WBPaper00065841:53_0
      WBPaper00065841:56_0
      WBPaper00065841:116_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_3
      cgc4386_cluster_6_4
      cgc4386_cluster_6_5
      cgc4489_group_22
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q50_down
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045294:0.1uM_TBBP_downregulated
      WBPaper00045294:50uM_DBAA_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046639:tyrosol_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00049311:sAg-MNP_regulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_C
    Interaction (104)
  Map_info: Map: X Position: 0.672056 Error: 0.047992
    Positive: Positive_clone: C25A11 Person_evidence: WBPerson506
          Author_evidence: Hardin JD
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4150
    Pseudo_map_position
  Reference (133)
  Remark: .3 gene was merged with .4 gene
    Sequence connection from [Koppen M, Hardin JD]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene