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WormBase Tree Display for Gene: WBGene00002004

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Name Class

WBGene00002004EvidencePaper_evidenceWBPaper00005342
SMapS_parentSequenceY53C10A
IdentityVersion1
NameCGC_namehsf-1Person_evidenceWBPerson1157
Sequence_nameY53C10A.12
Molecular_nameY53C10A.12
Y53C10A.12.1
CE22380
Y53C10A.12.2
Other_nameCELE_Y53C10A.12Accession_evidenceNDBBX284601
Public_namehsf-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhsf
AlleleWBVar02158119
WBVar01908070
WBVar01286052
WBVar01286053
WBVar01286055
WBVar01286056
WBVar01286057
WBVar01286059
WBVar01286060
WBVar01286066
WBVar01286071
WBVar01286078
WBVar01286080
WBVar01392297
WBVar01286081
WBVar01392298
WBVar01286084
WBVar02051152
WBVar01392299
WBVar01286085
WBVar01392301
WBVar01286086
WBVar01286087
WBVar01392302
WBVar00216222
WBVar01392303
WBVar01286092
WBVar00216223
WBVar01392304
WBVar00216224
WBVar01392305
WBVar01782803
WBVar00216225
WBVar00216227
WBVar00216230
WBVar00216231
WBVar00216232
WBVar00216233
WBVar00216236
WBVar02093571
WBVar00216238
WBVar00158100
WBVar01347356
WBVar00158101
WBVar00237096
WBVar00216241
WBVar00158102
WBVar00237097
WBVar01424953
WBVar00158103
WBVar01347367
WBVar01424954
WBVar00158104
WBVar00158105
WBVar00158106
WBVar00158108
WBVar01347379
WBVar00158109
WBVar00158110
WBVar01347390
WBVar00158111
WBVar00158112
WBVar01347401
WBVar00158113
WBVar00248994
WBVar00158114
WBVar01499739
WBVar01898144
WBVar01347412
WBVar00101181
WBVar01347423
WBVar01898145
WBVar00158115
WBVar00101182
WBVar00158116
WBVar00101183
WBVar01347434
WBVar02066547
WBVar00101184
WBVar00158117
WBVar02066548
WBVar00158118
WBVar00101185
WBVar00158119
WBVar02066549
WBVar00101186
WBVar01641200
WBVar00101187
WBVar00158120
WBVar00158121
WBVar00101188
WBVar00158122
WBVar01403649
WBVar00101189
WBVar01403651
WBVar00158123
WBVar00158124
WBVar01403653
WBVar01403654
WBVar00158125
WBVar00158126
WBVar00540098
WBVar02112369
WBVar00158127
WBVar00158128
WBVar00599365
WBVar00158129
WBVar00158131
WBVar00158132
WBVar00158133
WBVar00158134
WBVar00264492
WBVar00158135
WBVar00158136
WBVar01350485
WBVar00158137
WBVar00158138
WBVar00158139
WBVar00158140
WBVar02077009
WBVar00158141
WBVar02122511
WBVar02016577
WBVar02016578
WBVar02002063
WBVar02002064
WBVar01622946
WBVar02002065
WBVar01622947
WBVar02002066
WBVar00247534
WBVar00247535
WBVar00247536
WBVar01433430
WBVar01499788
WBVar02009891
WBVar01433432
WBVar01499055
WBVar01993464
WBVar01425755
WBVar00091886
WBVar01425766
WBVar00234038
WBVar01425788
WBVar00234039
WBVar01425799
WBVar00234040
WBVar02083893
WBVar00234041
WBVar00234042
WBVar01425822
WBVar01425833
WBVar01425855
WBVar01425888
WBVar02124753
WBVar02128629
WBVar02128630
WBVar02006275
WBVar01693827
WBVar00675793
WBVar00675794
WBVar01499999
WBVar00675795
WBVar00260318
WBVar00675796
WBVar00675797
WBVar00675798
WBVar00675799
WBVar00675800
WBVar01476268
WBVar00675801
WBVar01476269
WBVar01713592
WBVar01476270
WBVar00675802
WBVar00675803
WBVar01713593
WBVar00675804
WBVar01713594
WBVar00675805
WBVar01713595
WBVar01704920
WBVar00675806
WBVar01713596
WBVar00675807
WBVar01713597
WBVar01713598
WBVar00675808
WBVar01713599
WBVar01532328
WBVar00675809
WBVar01713600
WBVar00675810
WBVar01532329
WBVar01713601
WBVar00675811
WBVar01532330
WBVar01713602
WBVar01532331
WBVar00675812
WBVar01532332
WBVar01713603
WBVar00675813
WBVar02070549
WBVar01713604
WBVar00675814
WBVar01532333
WBVar01532334
WBVar02070550
WBVar01713605
WBVar00675815
WBVar00675816
WBVar01532335
WBVar01713606
WBVar00675817
WBVar01532336
WBVar02014195
WBVar00675818
WBVar01532337
WBVar00675819
WBVar01532338
WBVar00675820
WBVar00675821
WBVar00675822
WBVar00675823
WBVar00675824
WBVar00675825
WBVar00675826
WBVar00675827
WBVar00675828
WBVar00675829
WBVar02076721
WBVar00675830
WBVar02088730
WBVar00675831
WBVar00675832
WBVar00675833
WBVar00675834
WBVar00675835
WBVar00675836
WBVar00675837
WBVar00675838
WBVar02072239
WBVar00675839
WBVar00675840
WBVar00675841
WBVar00675842
WBVar00347129
WBVar00347130
WBVar00347131
WBVar00266074
WBVar00347132
WBVar02108068
WBVar00347133
WBVar01932685
WBVar02108069
WBVar00347134
WBVar00347135
WBVar01932686
WBVar00347136
WBVar01932687
WBVar00347137
WBVar01932690
WBVar00347138
WBVar00347139
WBVar01958004
WBVar01958006
WBVar01663827
WBVar00347140
WBVar01958008
WBVar00347141
WBVar01890453
WBVar01958010
WBVar01498959
WBVar01958012
WBVar01958013
Possibly_affected_byWBVar02153033
Strain (20)
RNASeq_FPKM (74)
GO_annotation (91)
Ortholog (42)
Structured_descriptionConcise_descriptionhsf-1 encodes the C. elegans heat-shock transcription factor ortholog; HSF-1 functions as a transcriptional regulator of stress-induced gene expression whose activity is required for heat-shock and proteotoxicity response, larval development, innate immunity, and regulation of adult lifespan; HSF-1 binds bovine calmodulin in vitro in a calcium-dependent manner.Paper_evidenceWBPaper00005342
WBPaper00005851
WBPaper00006377
WBPaper00024662
WBPaper00026999
WBPaper00027347
WBPaper00028353
WBPaper00028419
WBPaper00031011
Curator_confirmedWBPerson1843
Date_last_updated04 May 2010 00:00:00
Automated_descriptionEnables several functions, including calmodulin binding activity; identical protein binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including ascaroside biosynthetic process; defense response to other organism; and positive regulation of metabolic process. Located in cytoplasm; nuclear body; and nuclear stress granule. Part of chromatin. Expressed in several structures, including germ cell; hypodermis; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in Huntington's disease and cataract 5 multiple types. Is an ortholog of human HSF1 (heat shock transcription factor 1) and HSF2 (heat shock transcription factor 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:12858Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5224)
DOID:0110255Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5227)
DOID:83Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5227)
Disease_relevanceC. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes.Homo sapiensPaper_evidenceWBPaper00041564
Curator_confirmedWBPerson324
Date_last_updated29 May 2013 00:00:00
Molecular_infoCorresponding_CDSY53C10A.12
Corresponding_transcript (2)
Other_sequence (32)
Associated_featureWBsf665013
WBsf717585
WBsf978924
WBsf985423
WBsf220382
Gene_product_bindsWBsf919560
WBsf919561
WBsf919565
WBsf919566
WBsf919567
WBsf919568
WBsf919569
WBsf919570
WBsf919571
Transcription_factorWBTranscriptionFactor000178
Experimental_info (11)
Map_infoMapIPosition13.0131Error0.000976
PositivePositive_cloneY53C10AInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4416
5648
Reference (373)
MethodGene