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WormBase Tree Display for Gene: WBGene00002978

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Name Class

WBGene00002978SMapS_parentSequenceY105E8B
IdentityVersion1
NameCGC_namelev-11Person_evidenceWBPerson368
Sequence_nameY105E8B.1
Molecular_name (58)
Other_name (4)
Public_namelev-11
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlev
Reference_alleleWBVar00275207
AlleleWBVar00248753Inferred_automaticallyFrom strain object: RW3534
WBVar00248768Inferred_automaticallyFrom strain object: RW3566
WBVar00275206Inferred_automaticallyFrom strain object: ZZ1
WBVar00248777
WBVar00242238
WBVar00144257
WBVar02159334
WBVar00692995
WBVar00692996
WBVar00692997
WBVar02017066
WBVar00259293
WBVar00352868
WBVar00352869
WBVar00352870
WBVar00352871
WBVar00352872
WBVar00352873
WBVar02129098
WBVar00352874
WBVar02129099
WBVar00352875
WBVar02129100
WBVar00352876
WBVar00352877
WBVar00352878
WBVar00352879
WBVar01715152
WBVar01715153
WBVar00352880
WBVar00352881
WBVar01715154
WBVar00352882
WBVar00352883
WBVar00142649
WBVar00352884
WBVar00275207
WBVar00352885
WBVar00352886
WBVar00352887
WBVar00352888
WBVar02011378
WBVar00352889
WBVar01290468
WBVar00352890
WBVar01290469
WBVar01499739
WBVar01290470
WBVar00352891
WBVar00352892
WBVar00352893
WBVar00352894
WBVar00352895
WBVar00352896
WBVar00352897
WBVar00352898
WBVar00352899
WBVar00352900
WBVar00249011
WBVar00352901
WBVar00352902
WBVar00352903
WBVar00352904
WBVar00352905
WBVar00352906
WBVar00352907
WBVar01356634
WBVar01356645
WBVar01356656
WBVar01356674
WBVar01891255
WBVar01356676
WBVar01891256
WBVar00241501
WBVar02151120
WBVar00598090
WBVar01235773
WBVar00277508
WBVar01429192
WBVar01429193
WBVar00317324
WBVar01429194
WBVar01429198
WBVar01429200
WBVar02074609
WBVar01429201
WBVar01429202
WBVar01235784
WBVar01392813
WBVar01392815
WBVar01235795
WBVar01993792
WBVar00692911
WBVar00692912
WBVar00692913
WBVar00692914
WBVar00692915
WBVar00692916
WBVar00692917
WBVar00692918
WBVar00692919
WBVar00692920
WBVar00692921
WBVar00692922
WBVar00692923
WBVar00248312
WBVar00692924
WBVar00248313
WBVar00692925
WBVar00692926
WBVar01499999
WBVar00692927
WBVar00692928
WBVar01557665
WBVar00692929
WBVar01915533
WBVar01557666
WBVar00692930
WBVar01557667
WBVar01948593
WBVar00692931
WBVar00692932
WBVar00692933
WBVar00692934
WBVar01499823
WBVar00692935
WBVar01499641
WBVar00692936
WBVar00692937
WBVar02009958
WBVar00692938
WBVar00162291
WBVar00692939
WBVar00692940
WBVar00162292
WBVar00692941
WBVar00162293
WBVar00692942
WBVar00162294
WBVar00162295
WBVar00692943
WBVar00692944
WBVar00692945
WBVar00692946
WBVar00692947
WBVar00692948
WBVar01404136
WBVar00692949
WBVar00692950
WBVar00692951
WBVar00692952
WBVar01495977
WBVar00692953
WBVar01435003
WBVar00692954
WBVar01435004
WBVar00692955
WBVar00692956
WBVar00692957
WBVar00692958
WBVar01497271
WBVar00692959
WBVar00692960
WBVar00692961
WBVar01499298
WBVar00692962
WBVar00692963
WBVar00692964
WBVar02039772
WBVar00692965
WBVar02039775
WBVar00692966
WBVar00692967
WBVar00692968
WBVar01412325
WBVar00692969
WBVar00692970
WBVar01498939
WBVar00692971
WBVar00692972
WBVar00543090
WBVar00692973
WBVar00692974
WBVar00692975
WBVar00692976
WBVar00692977
WBVar00692978
WBVar00692979
WBVar00692980
WBVar00692981
WBVar00692982
WBVar00692983
WBVar00692984
WBVar00692985
WBVar00692986
WBVar01502635
WBVar01502636
WBVar00692987
WBVar00692988
WBVar00692989
WBVar00692990
WBVar00692991
WBVar00692992
WBVar00692993
WBVar02028552
WBVar00692994
Legacy_informationx12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal).
See also e1724
[Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping.
[C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS.
[C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK]
StrainWBStrain00002959
WBStrain00033515
WBStrain00033518
WBStrain00033524
WBStrain00040917
WBStrain00040918
WBStrain00004923
RNASeq_FPKM (74)
GO_annotation (20)
Ortholog (47)
Structured_descriptionConcise_descriptionlev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line.Paper_evidenceWBPaper00002748
WBPaper00004944
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111597Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12011)
DOID:0110926Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:0110309Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:0110457Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:3969Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:0110932Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12011)
DOID:0080326Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:0080102Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:2218Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12013)
Molecular_infoCorresponding_CDS (19)
Corresponding_CDS_historyY105E8B.1b:wp62
Y105E8B.1b:wp114
Y105E8B.1c:wp62
Corresponding_transcript (20)
Other_sequenceD38540
D38541
D38542
PT02847
WBC01402_1
FG971696.1
HBC10599_1
FF680067.1
EY462788.1
EX910915.1
EY464315.1
SS01171
FG980540.1
HSC00510_1
FC544713.1
FK806177.1
FG975177.1
FG974479.1
FG974053.1
HG08144
FF680643.1
FK801456.1
FF681115.1
FG973046.1
BG577835.1
MI06813
FG977019.1
GR367773.1
FG978816.1
EY462569.1
FG977599.1
FG980587.1
FG973525.1
FG972515.1
FG972635.1
FG972427.1
ES566948.1
FG980607.1
FG974913.1
FG970774.1
Dviv_isotig01174
AI096017.1
BUC01311_1
FG979151.1
EX500773.1
GW412705.1
FG971480.1
FG976200.1
FG977894.1
FG973238.1
EX915478.1
NAC01588_1
FG976995.1
CBC09683_1
EX561457.1
FF679743.1
AI313770.1
ES414274.1
FF681439.1
FF678895.1
FK801943.1
FG979844.1
ASC04697_1
FG978672.1
FG979289.1
FG971346.1
FG971321.1
FF680605.1
PT01044
HG08923
ES742550.1
FG970711.1
FG975750.1
FG975680.1
FG978382.1
BE760999.1
BXC00949_1
EX546307.1
FG978147.1
CB038277.1
PPC02116_1
EX546028.1
FG975349.1
ES563431.1
BE217707.1
HBC01120_1
FG974472.1
EX911110.1
FG972812.1
EX537456.1
FG972526.1
DA00160
TM01151
FG971190.1
FG978217.1
XI01191
JI214527.1
FG972859.1
MJC00351_1
FJ655903.1
FG973412.1
GO249034.1
FG973583.1
GPC00554_1
Acan_isotig00103
CSC00763_1
FG972459.1
FF681016.1
CB038181.1
BE202306.1
FG979733.1
FG980081.1
TSC01040_1
FG975959.1
FF680101.1
FG973005.1
HG08495
FG974185.1
HBC14270_1
TDC00858_1
FG971446.1
FF679857.1
Y19221.1
FG973062.1
FD516018.1
FF679859.1
FG980434.1
ES413695.1
FG973744.1
FG977248.1
FG971972.1
FF681575.1
PVC00840_1
GRC00453_1
CRC03050_1
FG977386.1
FG973978.1
MI00997
FC810253.1
FG978780.1
AJ224966.1
ES411437.1
MI06036
DAC00081_1
DA04805
AI096121.1
FG972687.1
FG975120.1
EX013954.1
FG976189.1
FG972108.1
CB037762.1
FG976782.1
FG971560.1
ES410384.1
Acan_isotig00108
FG978916.1
JI471282.1
FG976960.1
FG975087.1
OVC00801_1
HGC08828_1
FG978107.1
BE899665.1
FG978658.1
GW412508.1
FG980695.1
EX012406.1
FG980568.1
FG980624.1
ES564406.1
CBC00908_3
FG977727.1
MH07965
FF679563.1
FF681025.1
FG971298.1
FG974574.1
MC05002
FG979666.1
Dviv_isotig01175
FG974702.1
FG977012.1
MCC02354_1
FF679558.1
HBC07157_1
GW408961.1
AM743952.1
TS01635
FG973556.1
FF680333.1
FG974088.1
Tcol_isotig02429
EY465225.1
FG973872.1
FG970861.1
FF681493.1
FG974322.1
FG978763.1
FG976521.1
FG980846.1
FG980240.1
Hbac_isotig00014
PEC00078_1
FG976056.1
FG975193.1
FG971876.1
FG974969.1
BF169293.1
EY465711.1
EU131541.1
MIC00674_1
EY469585.1
FG980279.1
FG977793.1
FG979751.1
GR11973
MHC06991_1
FF680128.1
FG980243.1
AI066889.1
FG971409.1
FG971769.1
FG973798.1
FG977863.1
ES408916.1
FG973863.1
FG980662.1
RSC03219_1
FF680774.1
HBC00440_1
DA02385
EY471104.1
FG971760.1
FG972227.1
AF546757.1
EX538340.1
JI462505.1
EX007012.1
FF680149.1
FG970735.1
FG975687.1
FG971186.1
FG977274.1
GW406139.1
FG974481.1
FG971225.1
FG974575.1
XIC02558_1
FG980055.1
EY470403.1
FG971085.1
EX008273.1
FG976252.1
JI479289.1
MC00914
FG978922.1
FG980029.1
PT00467
CJC15149_1
FG978353.1
EX014056.1
AS14007
FG981148.1
CGC01120_1
JI169886.1
FG977420.1
FK807357.1
FG974309.1
FC548317.1
FG979915.1
FG972644.1
FG973912.1
HBC20594_1
HBC00200_1
FG979858.1
FG978811.1
FG973721.1
SS00615
FF680920.1
Tcir_isotig10267
FF679757.1
PSC00361_1
FG978956.1
AF000607.1
FG971032.1
TDC01038_1
FG979624.1
FG975226.1
FG976827.1
ACC19562_1
GO249744.1
EX564316.1
BE420513.1
FG975852.1
FG976916.1
CSC00639_1
GRC02622_1
Oden_isotig26493
JI477797.1
FG972714.1
EX828262.1
MJ04971
CK850057.1
ES411375.1
FG975981.1
FG975827.1
HBC08828_1
FG971122.1
FG976086.1
BF400331.1
MI03147
MH01212
ACC11709_1
FG972550.1
AF419300.1
FF679951.1
PSC00742
JI216186.1
EL889973.1
DAC01340_1
EX543079.1
FG973338.1
FF681322.1
ES672745.1
FG972785.1
FG975390.1
EY471483.1
ES739281.1
BE225562.1
FG977147.1
FG977293.1
EY473360.1
FC815637.1
HBC00148_1
EX549175.1
FG980795.1
BXC00048_1
HG03504
FG972390.1
Tcol_isotig02431
FG972472.1
FG973799.1
Dviv_isotig01178
EX536520.1
FG980184.1
EX915220.1
FG978571.1
FG981072.1
FG977687.1
FG980507.1
Oden_isotig07126
FG980181.1
CRC00045_1
FG978357.1
FF679452.1
FG971524.1
FG976844.1
FC555094.1
FG976737.1
FG972707.1
FG979191.1
EX910347.1
BUC00143_1
AI438750.1
FG979591.1
FG980179.1
FG970691.1
JI180367.1
FD515391.1
FG975488.1
BMC04766_1
FF680180.1
FG974241.1
HBC04876_1
FG979320.1
FG978871.1
JI482010.1
PTC00333_1
EX535409.1
BE132585.1
FG973149.1
FG972654.1
MC04602
AA907973.1
FK805087.1
FG976019.1
FG975550.1
BMC00669_1
AA294458.1
Hbac_isotig00013
CB038111.1
FG975985.1
FG975616.1
GR463911.1
FG971354.1
FF680107.1
EY461484.1
FG980808.1
ES566442.1
MIC02022_1
FG973099.1
ES412840.1
AA610987.1
GO250115.1
FG973143.1
FG976650.1
FG974504.1
CBC00908_2
ASC26141_1
OOC01731_1
FG971805.1
EX911490.1
EX555660.1
FG972581.1
FG978928.1
Dviv_isotig01176
FG977596.1
FF680657.1
FG979673.1
FG973056.1
FG980818.1
TMC00234_1
FG977195.1
EY471058.1
EX013101.1
BXC04790_1
EF533995.1
SSC00411_1
Hbac_isotig06030
HBC05799_1
TSC00987_1
FG975040.1
FG975567.1
FG976701.1
FG977785.1
EX912357.1
ASC13815_1
FG977926.1
FG976290.1
BMC07313_1
CB037093.1
FG979115.1
FG973242.1
HGC05859_1
AI130353.1
FG974865.1
FG975500.1
FF681062.1
HBC02783_1
FG973209.1
JI459475.1
SR00241
MIC05172_1
FG975451.1
AA080831.1
BE202325.1
FF681524.1
EX566113.1
FG972479.1
CGC00422_1
FG970745.1
AS01772
FG974605.1
FG972286.1
JI473797.1
HBC23162_1
FG971247.1
CV200563.1
FG973973.1
FG970805.1
J04669.1
CBC01773_1
EY463267.1
Acan_isotig00107
JI475878.1
FG975871.1
FG974960.1
ACC06680_1
FG974155.1
CR02766
FG971011.1
CBC09079_1
FG979298.1
OVC00551_1
DA02384
FG979596.1
TM01513
BG734382.1
FF681219.1
FG974208.1
FG973883.1
HC01930
PP00432
HC00472
FG973013.1
FG972829.1
FG971869.1
EF552222.1
FG976245.1
CJC03605_1
HCC06886_1
FG973253.1
EE724202.1
FG980917.1
BG734443.1
HBC21510_1
FG977467.1
FG972524.1
FG974661.1
EX828585.1
FG977171.1
FG978993.1
FG980049.1
FG973458.1
FG981107.1
FG980628.1
FF680468.1
EY459842.1
FG972011.1
FG978569.1
FG972517.1
FG978026.1
HBC16290_1
AW499467.1
GW406922.1
FG972942.1
MH02432
CR02934
FG979630.1
FG978271.1
FG970813.1
CR00047
Oden_isotig07127
EL890460.1
GO250215.1
EY471775.1
FF681718.1
GO250230.1
FG975278.1
FG979113.1
FD516876.1
TMC00737_1
FF681592.1
FG978577.1
FG971262.1
DA05096
FF681098.1
FG973256.1
MI03894
TMC01189_1
FG979177.1
FG971632.1
FG979981.1
DAC00935_1
FG979559.1
FG976465.1
FG975530.1
FG974284.1
FG978121.1
FG976860.1
EY465083.1
TDC02420_1
DA03929
FG980462.1
FG978511.1
Acan_isotig00105
PP02222
FF678648.1
JI166799.1
FG979201.1
FF680799.1
FG974476.1
FG979042.1
FG977953.1
FG975342.1
FG973434.1
HBC14084_1
EX500481.1
JI176757.1
AA934313.1
FG979636.1
FG976144.1
HBC22362_1
FK800093.1
HBC06268_1
FF681535.1
TS00522
FG971989.1
JI216266.1
EY467828.1
BU087084.1
WBC00060_1
L41633.1
FG975559.1
GU130141.1
XI00199
EY472083.1
FG976366.1
FG978585.1
JI175599.1
HBC00135_2
FG976674.1
Oden_isotig07124
FF680930.1
BUC00877_1
EL888158.1
ACC07259_1
BE760992.1
FG978056.1
FG979373.1
FG974754.1
FG978027.1
AI057962.1
FG978696.1
EX539927.1
SSC02755_1
FG971638.1
FC548153.1
AA610978.1
FG976627.1
EY473604.1
FG979628.1
FF680790.1
FG972735.1
EY467529.1
Tcol_isotig02434
FG979058.1
MI06734
FG975591.1
Dviv_isotig01172
OOC02713_1
EU573931.1
FD515516.1
DA03801
Oden_isotig07123
ES742882.1
FG978316.1
FG975230.1
FG979497.1
FG972793.1
FG972776.1
MHC02994_1
FG972236.1
FG972012.1
GR13437
FG974296.1
FG975590.1
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Associated_feature (35)
Experimental_infoRNAi_result (31)
Expr_pattern (15)
Drives_construct (12)
Construct_productWBCnstr00010369
WBCnstr00012505
WBCnstr00016244
WBCnstr00041176
AntibodyWBAntibody00000099
WBAntibody00000422
WBAntibody00000423
WBAntibody00000472
Microarray_results (61)
Expression_cluster (304)
Interaction (175)
WBProcessWBbiopr:00000006
Map_infoMapIPosition25.8125Error0.018971
Well_ordered
PositivePositive_cloneY105E8BInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_data2_point209
213
214
327
5106
6076
Multi_point (11)
Pos_neg_data (13)
Reference (90)
RemarkData extracted from Williams & Waterston 1994
The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02
MethodGene