WormBase Tree Display for Gene: WBGene00002978
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WBGene00002978 | SMap | S_parent | Sequence | Y105E8B | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lev | ||||||
Reference_allele | WBVar00275207 | ||||||
Allele | WBVar00248753 | Inferred_automatically | From strain object: RW3534 | ||||
WBVar00248768 | Inferred_automatically | From strain object: RW3566 | |||||
WBVar00275206 | Inferred_automatically | From strain object: ZZ1 | |||||
WBVar00248777 | |||||||
WBVar00242238 | |||||||
WBVar00144257 | |||||||
WBVar02159334 | |||||||
WBVar00692995 | |||||||
WBVar00692996 | |||||||
WBVar00692997 | |||||||
WBVar02017066 | |||||||
WBVar00259293 | |||||||
WBVar00352868 | |||||||
WBVar00352869 | |||||||
WBVar00352870 | |||||||
WBVar00352871 | |||||||
WBVar00352872 | |||||||
WBVar00352873 | |||||||
WBVar02129098 | |||||||
WBVar00352874 | |||||||
WBVar02129099 | |||||||
WBVar00352875 | |||||||
WBVar02129100 | |||||||
WBVar00352876 | |||||||
WBVar00352877 | |||||||
WBVar00352878 | |||||||
WBVar00352879 | |||||||
WBVar01715152 | |||||||
WBVar01715153 | |||||||
WBVar00352880 | |||||||
WBVar00352881 | |||||||
WBVar01715154 | |||||||
WBVar00352882 | |||||||
WBVar00352883 | |||||||
WBVar00142649 | |||||||
WBVar00352884 | |||||||
WBVar00275207 | |||||||
WBVar00352885 | |||||||
WBVar00352886 | |||||||
WBVar00352887 | |||||||
WBVar00352888 | |||||||
WBVar02011378 | |||||||
WBVar00352889 | |||||||
WBVar01290468 | |||||||
WBVar00352890 | |||||||
WBVar01290469 | |||||||
WBVar01499739 | |||||||
WBVar01290470 | |||||||
WBVar00352891 | |||||||
WBVar00352892 | |||||||
WBVar00352893 | |||||||
WBVar00352894 | |||||||
WBVar00352895 | |||||||
WBVar00352896 | |||||||
WBVar00352897 | |||||||
WBVar00352898 | |||||||
WBVar00352899 | |||||||
WBVar00352900 | |||||||
WBVar00249011 | |||||||
WBVar00352901 | |||||||
WBVar00352902 | |||||||
WBVar00352903 | |||||||
WBVar00352904 | |||||||
WBVar00352905 | |||||||
WBVar00352906 | |||||||
WBVar00352907 | |||||||
WBVar01356634 | |||||||
WBVar01356645 | |||||||
WBVar01356656 | |||||||
WBVar01356674 | |||||||
WBVar01891255 | |||||||
WBVar01356676 | |||||||
WBVar01891256 | |||||||
WBVar00241501 | |||||||
WBVar02151120 | |||||||
WBVar00598090 | |||||||
WBVar01235773 | |||||||
WBVar00277508 | |||||||
WBVar01429192 | |||||||
WBVar01429193 | |||||||
WBVar00317324 | |||||||
WBVar01429194 | |||||||
WBVar01429198 | |||||||
WBVar01429200 | |||||||
WBVar02074609 | |||||||
WBVar01429201 | |||||||
WBVar01429202 | |||||||
WBVar01235784 | |||||||
WBVar01392813 | |||||||
WBVar01392815 | |||||||
WBVar01235795 | |||||||
WBVar01993792 | |||||||
WBVar00692911 | |||||||
WBVar00692912 | |||||||
WBVar00692913 | |||||||
WBVar00692914 | |||||||
WBVar00692915 | |||||||
WBVar00692916 | |||||||
WBVar00692917 | |||||||
WBVar00692918 | |||||||
WBVar00692919 | |||||||
WBVar00692920 | |||||||
WBVar00692921 | |||||||
WBVar00692922 | |||||||
WBVar00692923 | |||||||
WBVar00248312 | |||||||
WBVar00692924 | |||||||
WBVar00248313 | |||||||
WBVar00692925 | |||||||
WBVar00692926 | |||||||
WBVar01499999 | |||||||
WBVar00692927 | |||||||
WBVar00692928 | |||||||
WBVar01557665 | |||||||
WBVar00692929 | |||||||
WBVar01915533 | |||||||
WBVar01557666 | |||||||
WBVar00692930 | |||||||
WBVar01557667 | |||||||
WBVar01948593 | |||||||
WBVar00692931 | |||||||
WBVar00692932 | |||||||
WBVar00692933 | |||||||
WBVar00692934 | |||||||
WBVar01499823 | |||||||
WBVar00692935 | |||||||
WBVar01499641 | |||||||
WBVar00692936 | |||||||
WBVar00692937 | |||||||
WBVar02009958 | |||||||
WBVar00692938 | |||||||
WBVar00162291 | |||||||
WBVar00692939 | |||||||
WBVar00692940 | |||||||
WBVar00162292 | |||||||
WBVar00692941 | |||||||
WBVar00162293 | |||||||
WBVar00692942 | |||||||
WBVar00162294 | |||||||
WBVar00162295 | |||||||
WBVar00692943 | |||||||
WBVar00692944 | |||||||
WBVar00692945 | |||||||
WBVar00692946 | |||||||
WBVar00692947 | |||||||
WBVar00692948 | |||||||
WBVar01404136 | |||||||
WBVar00692949 | |||||||
WBVar00692950 | |||||||
WBVar00692951 | |||||||
WBVar00692952 | |||||||
WBVar01495977 | |||||||
WBVar00692953 | |||||||
WBVar01435003 | |||||||
WBVar00692954 | |||||||
WBVar01435004 | |||||||
WBVar00692955 | |||||||
WBVar00692956 | |||||||
WBVar00692957 | |||||||
WBVar00692958 | |||||||
WBVar01497271 | |||||||
WBVar00692959 | |||||||
WBVar00692960 | |||||||
WBVar00692961 | |||||||
WBVar01499298 | |||||||
WBVar00692962 | |||||||
WBVar00692963 | |||||||
WBVar00692964 | |||||||
WBVar02039772 | |||||||
WBVar00692965 | |||||||
WBVar02039775 | |||||||
WBVar00692966 | |||||||
WBVar00692967 | |||||||
WBVar00692968 | |||||||
WBVar01412325 | |||||||
WBVar00692969 | |||||||
WBVar00692970 | |||||||
WBVar01498939 | |||||||
WBVar00692971 | |||||||
WBVar00692972 | |||||||
WBVar00543090 | |||||||
WBVar00692973 | |||||||
WBVar00692974 | |||||||
WBVar00692975 | |||||||
WBVar00692976 | |||||||
WBVar00692977 | |||||||
WBVar00692978 | |||||||
WBVar00692979 | |||||||
WBVar00692980 | |||||||
WBVar00692981 | |||||||
WBVar00692982 | |||||||
WBVar00692983 | |||||||
WBVar00692984 | |||||||
WBVar00692985 | |||||||
WBVar00692986 | |||||||
WBVar01502635 | |||||||
WBVar01502636 | |||||||
WBVar00692987 | |||||||
WBVar00692988 | |||||||
WBVar00692989 | |||||||
WBVar00692990 | |||||||
WBVar00692991 | |||||||
WBVar00692992 | |||||||
WBVar00692993 | |||||||
WBVar02028552 | |||||||
WBVar00692994 | |||||||
Legacy_information | x12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal). | ||||||
See also e1724 | |||||||
[Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping. | |||||||
[C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS. | |||||||
[C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK] | |||||||
Strain | WBStrain00002959 | ||||||
WBStrain00033515 | |||||||
WBStrain00033518 | |||||||
WBStrain00033524 | |||||||
WBStrain00040917 | |||||||
WBStrain00040918 | |||||||
WBStrain00004923 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (47) | |||||||
Structured_description | Concise_description | lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. | Paper_evidence | WBPaper00002748 | |||
WBPaper00004944 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0111597 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||
DOID:0110926 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||
DOID:0110309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||
DOID:0110457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||
DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||
DOID:0110932 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||
DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||
DOID:0080102 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||
DOID:2218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12013) | ||||
Molecular_info | Corresponding_CDS (19) | ||||||
Corresponding_CDS_history | Y105E8B.1b:wp62 | ||||||
Y105E8B.1b:wp114 | |||||||
Y105E8B.1c:wp62 | |||||||
Corresponding_transcript (20) | |||||||
Other_sequence (913) | |||||||
Associated_feature (35) | |||||||
Experimental_info | RNAi_result (31) | ||||||
Expr_pattern (15) | |||||||
Drives_construct (12) | |||||||
Construct_product | WBCnstr00010369 | ||||||
WBCnstr00012505 | |||||||
WBCnstr00016244 | |||||||
WBCnstr00041176 | |||||||
Antibody | WBAntibody00000099 | ||||||
WBAntibody00000422 | |||||||
WBAntibody00000423 | |||||||
WBAntibody00000472 | |||||||
Microarray_results (61) | |||||||
Expression_cluster (304) | |||||||
Interaction (175) | |||||||
WBProcess | WBbiopr:00000006 | ||||||
Map_info | Map | I | Position | 25.8125 | Error | 0.018971 | |
Well_ordered | |||||||
Positive | Positive_clone | Y105E8B | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 209 | |||||
213 | |||||||
214 | |||||||
327 | |||||||
5106 | |||||||
6076 | |||||||
Multi_point | 203 | ||||||
246 | |||||||
291 | |||||||
577 | |||||||
960 | |||||||
1781 | |||||||
2221 | |||||||
2331 | |||||||
3094 | |||||||
3095 | |||||||
5057 | |||||||
Pos_neg_data (13) | |||||||
Reference (90) | |||||||
Remark | Data extracted from Williams & Waterston 1994 | ||||||
The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02 | |||||||
Method | Gene |