WormBase Tree Display for Gene: WBGene00006750

WBGene00006750 SMap: S_parent: Sequence: T10A3
  Identity: Version: 1
    Name: CGC_name: unc-10 Person_evidence: WBPerson261
      Sequence_name: T10A3.1
      Molecular_name (18)
      Other_name: rim-1
        Rim Paper_evidence: WBPaper00013595
        CELE_T10A3.1 Accession_evidence: NDB BX284606
      Public_name: unc-10
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142961
    Allele: WBVar00000036 Inferred_automatically: From strain object: DA591
      WBVar00142980
      WBVar00054232
      WBVar00088822
      WBVar02158529
      WBVar02158667
      WBVar02159347
      WBVar00088829
      WBVar01945653
      WBVar01487192
      WBVar00599134
      WBVar01825236
      WBVar00080358
      WBVar00047961
      WBVar00302873
      WBVar01489593
      WBVar00080361
      WBVar00088121
      WBVar00047966
      WBVar00088123
      WBVar00088859
      WBVar00088860
      WBVar00047971
      WBVar00047976
      WBVar00047981
      WBVar01490916
      WBVar01499933
      WBVar01159733
      WBVar01499934
      WBVar02046539
      WBVar01159734
      WBVar01159735
      WBVar01159736
      WBVar01159737
      WBVar02064708
      WBVar01159738
      WBVar02064709
      WBVar01159739
      WBVar01159740
      WBVar01159741
      WBVar01159742
      WBVar01159743
      WBVar01499760
      WBVar01499761
      WBVar01159744
      WBVar01159745
      WBVar01159746
      WBVar01159747
      WBVar01849056
      WBVar02045052
      WBVar01159748
      WBVar01159749
      WBVar01159750
      WBVar01159751
      WBVar01159752
      WBVar01159753
      WBVar01159754
      WBVar01159755
      WBVar01159756
      WBVar01159757
      WBVar01159758
      WBVar00142961
      WBVar01159759
      WBVar01159760
      WBVar01159761
      WBVar01159762
      WBVar01159763
      WBVar01159764
      WBVar01159765
      WBVar01159766
      WBVar01159767
      WBVar01159768
      WBVar01159769
      WBVar01159770
      WBVar01159771
      WBVar01159772
      WBVar01159773
      WBVar01159774
      WBVar01159775
      WBVar01159776
      WBVar01159777
      WBVar01159778
      WBVar01159779
      WBVar01159780
      WBVar01159781
      WBVar01159782
      WBVar01159783
      WBVar01159784
      WBVar01159785
      WBVar01159786
      WBVar01159787
      WBVar01159788
      WBVar01159789
      WBVar01159790
      WBVar01159791
      WBVar00508073
      WBVar01159792
      WBVar00508074
      WBVar01159793
      WBVar01815932
      WBVar01815933
      WBVar01159794
      WBVar00508075
      WBVar01758721
      WBVar01758722
      WBVar01159795
      WBVar00508076
      WBVar01159796
      WBVar00508077
      WBVar00508078
      WBVar01159797
      WBVar00508079
      WBVar01159798
      WBVar01159799
      WBVar00508080
      WBVar01159800
      WBVar00508081
      WBVar01159801
      WBVar00508082
      WBVar00508083
      WBVar02151542
      WBVar01159802
      WBVar00508084
      WBVar00508085
      WBVar00508086
      WBVar00508087
      WBVar00508088
      WBVar00508089
      WBVar00508090
      WBVar00260879
      WBVar01883226
      WBVar00508091
      WBVar01883227
      WBVar00508092
      WBVar01883228
      WBVar01883229
      WBVar01883230
      WBVar01883231
      WBVar01883232
      WBVar01883233
      WBVar01883234
      WBVar01883235
      WBVar01883236
      WBVar01883237
      WBVar00098970
      WBVar00098971
      WBVar00095004
      WBVar01499867
      WBVar00095005
      WBVar01499868
      WBVar01499685
      WBVar00088819
      WBVar01500067
    Legacy_information: e102 : weak coiler tends to back loopy movement in reverse; fairly active slightly small and thin. ES3 ME2. NA2 (e126).
      [C.elegansII] e102 : weak coiler, tends to back, loopy movement in reverse; fairly active; slightly small and thin; Ric. ES3 ME2. OA1: e126. [Brenner 1974; Nguyen et al. 1995]
      [Nonet M] unc-10(e102) was phenotypically rescued by both cosmid C34H12 and a 16 kb BamHI/KpnI subclone of this cosmid that contains effectively only the rim-1 gene. The rim-1 gene (rim for Rab Interacting Molecule) is the combined genefinder products T10A3.1 and K03A1.3 (with several mistakes in the prediction by genefinder). Furthermore, unc-10(md330) and unc-10(md1117) both contain deletions of the vast majority of the rim-1 gene. Specifically, md1117 deleted 8.6 kb that extends from approximately 500 bp 5' of the atg to 200 bp 3' of the TAA of the rim-1 gene product.
      [Nonet M] Encodes Rab-3 interacting protein.
    Strain: WBStrain00002752
      WBStrain00027194
      WBStrain00029061
      WBStrain00004100
      WBStrain00005485
      WBStrain00005508
      WBStrain00005509
      WBStrain00051853
    RNASeq_FPKM (74)
    GO_annotation (32)
    Ortholog: WBGene00051358 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00032220 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00139400 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00135410 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00232519 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g3825 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g1828 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g2185 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g20017 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g2836 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g20577 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g20578 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g5642 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP32.g5643 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g20645 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g4509 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g21270 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_09484.g22094 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-10 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g12505 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00022.g1323 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_00207 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024741 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g01557 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g13176 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0202100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g19374 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00238655 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00238656 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00089921 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00257102 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00290044 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0053547 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1656 Danio rerio From_analysis: OrthoFinder
            OrthoInspector
            PhylomeDB
      ZFIN:ZDB-GENE-060503-893 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-060503-788 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-101223-4 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-110103-1 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-090312-135 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:17283 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:21292 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:17282 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:16183 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      MGI:2152971 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2152972 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2674366 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      MGI:2443331 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
            PhylomeDB
      RGD:628762 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
            PhylomeDB
      RGD:620000 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620001 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:628695 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
    Structured_description: Concise_description: unc-10 encodes a protein with zinc-finger, Q/N-rich, PDZ, and C2 domains that is homologous to vertebrate Rim1, a presynaptic protein which binds, and effects the activity of, synaptic vesicle-associated GTP-Rab3; UNC-10 is required for normal locomotion and synaptic transmission, and localizes to a subdomain of presynaptic termini, where it probably acts to regulate the priming step of presynaptic vesicle fusion by promoting conformational changes in syntaxin. Paper_evidence: WBPaper00002487
            WBPaper00004891
            WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables small GTPase binding activity. Involved in several processes, including chemical synaptic transmission; defecation; and positive regulation of cholinergic synaptic transmission. Located in axon and presynaptic active zone. Expressed in dorsal nerve cord; nerve ring; nervous system; uv1; and ventral nerve cord. Is an ortholog of human RIMS1 (regulating synaptic membrane exocytosis 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T10A3.1a
      T10A3.1b
      T10A3.1c
      T10A3.1d
      T10A3.1e
      T10A3.1f
    Corresponding_transcript: T10A3.1a.1
      T10A3.1b.1
      T10A3.1c.1
      T10A3.1d.1
      T10A3.1e.1
      T10A3.1f.1
    Other_sequence (30)
    Associated_feature (22)
  Experimental_info: RNAi_result (19)
    Expr_pattern: Chronogram1591
      Expr2418
      Expr14780
      Expr15235
      Expr15236
      Expr1017493
      Expr1032824
      Expr1156587
      Expr2017837
      Expr2035973
    Drives_construct: WBCnstr00003280
      WBCnstr00034173
    Construct_product (11)
    Antibody: WBAntibody00000412
      WBAntibody00000866
      WBAntibody00001456
      WBAntibody00001656
      WBAntibody00001729
      WBAntibody00002171
    Microarray_results: SMD_K03A1.3
      SMD_T10A3.1
      173800_at
      183507_at
      191935_s_at
      A_12_P112094
      A_12_P155335
      A_12_P155336
      A_12_P159320
      Aff_K03A1.3
      Aff_T10A3.1
      GPL13394_WBGene00006750
      GPL13914_T10A3.1
      GPL14144_T10A3.1a_2418-2477_0.810_79_C
      GPL14144_T10A3.1a_4608-4667_0.955_1_A
      GPL14144_T10A3.1a_4640-4699_0.949_3_B
      GPL19516_CGZ0034459
      GPL19516_CGZ0034460
      GPL21109_T10A3.1a
      GPL21109_T10A3.1b
      GPL3518_CE30169
      GPL8304_CE_WBGene00006750_A
      GPL8673_T10A3_1aP04234
      GPL8673_T10A3_1aP04249
      GPL8673_T10A3_1aP04580
      GPL8673_T10A3_1bP02664
      GPL8673_T10A3_1bP03147
      GPL8673_T10A3_1bP03427
      GPL9450_T10A3.1a
      cea2.d.38429
    Expression_cluster (208)
    Interaction (82)
  Map_info: Map: X Position: -1.7816 Error: 0.001118
    Well_ordered
    Positive: Positive_clone: C34H12
        T10A3 Person_evidence: WBPerson451
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 147
        182
        3912
        3913
        6198
      Multi_point (23)
      Pos_neg_data (13)
  Reference (108)
  Remark: Sequence connection from [Koushika SP, Nonet M]
    Other name from JA Hodgkin, 09/02/2002
    unc-10 is the same as rim-1 and therefore rim-1 was merged into unc-10 based on advice from JAH
  Method: Gene