WormBase Tree Display for Gene: WBGene00006759

WBGene00006759 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 3
    Name: CGC_name: unc-22 Person_evidence: WBPerson261
      Sequence_name: ZK617.1
      Molecular_name (27)
      Other_name: twitchin kinase Paper_evidence: WBPaper00002642
        twitchin Paper_evidence: WBPaper00031595
        CELE_ZK617.1 Accession_evidence: NDB BX284604
      Public_name: unc-22
    DB_info: Database (15)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 23 Feb 2010 15:11:48 WBPerson4025 Event: Acquires_merge: WBGene00014010
        3 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303099
      Acquires_merge: WBGene00014010
      Split_into: WBGene00303099
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142944
    Allele: WBVar00142944 Inferred_automatically (12)
      WBVar00241653 Inferred_automatically (81)
      WBVar00241662 Inferred_automatically: From strain object: BC177
      WBVar00241658 Inferred_automatically: From strain object: BC18
      WBVar00241657 Inferred_automatically: From strain object: BC200
          From strain object: RW1324
          From strain object: RW1333
      WBVar00241654 Inferred_automatically: From strain object: BC21
      WBVar00241661 Inferred_automatically: From strain object: BC96
      WBVar00054567 Inferred_automatically: From strain object: BW1161
      WBVar00054572 Inferred_automatically: From strain object: BW1163
      WBVar00054577 Inferred_automatically: From strain object: BW1166
      WBVar00054582 Inferred_automatically: From strain object: BW1168
      WBVar00054587 Inferred_automatically: From strain object: BW1169
      WBVar00054592 Inferred_automatically: From strain object: BW1176
      WBVar00142963 Inferred_automatically: From strain object: CB105
      WBVar00143805 Inferred_automatically: From strain object: CB1179
      WBVar00088556 Inferred_automatically: From strain object: DR185
          From strain object: DR245
          From strain object: DR52
      WBVar00088557 Inferred_automatically: From strain object: DR54
      WBVar00088684 Inferred_automatically: From strain object: DR842
      WBVar00241672 Inferred_automatically: From strain object: RW5020
      WBVar00248729 Inferred_automatically: From strain object: RW7096
          From strain object: RW7097
      WBVar00248751 Inferred_automatically: From strain object: RW7097
      WBVar00241378 Inferred_automatically: From strain object: SX158
          From strain object: SX494
      WBVar00241380 Inferred_automatically: From strain object: SX178
          From strain object: SX278
      WBVar00296609 Inferred_automatically: From strain object: VC1923
      WBVar00296620 Inferred_automatically: From strain object: VC2362
      WBVar00296653 Inferred_automatically: From strain object: VC3083
      WBVar00242663
      WBVar00248752
      WBVar00275406
      WBVar00239150
      WBVar00241660
      WBVar00242220
      WBVar00248723
      WBVar00143375
      WBVar00239151
      WBVar00241733
      WBVar02144448
      WBVar00241673
      WBVar00241806
      WBVar00241790
      WBVar00242219
      WBVar00241675
      WBVar00248724
      WBVar02148954
      WBVar00143921
      WBVar00241792
      WBVar00241820
      WBVar00241755
      WBVar00241674
      WBVar00239152
      WBVar00241810
      WBVar00143407
      WBVar00143531
      WBVar00241822
      WBVar00144827
      WBVar00241800
      WBVar00144556
      WBVar00275219
      WBVar00241799
      WBVar00089759
      WBVar00241804
      WBVar00241665
      WBVar00248730
      WBVar00241821
      WBVar00143361
      WBVar00239146
      WBVar00241814
      WBVar00241659
      WBVar00089758
      WBVar00241743
      WBVar00143111
      WBVar00143401
      WBVar00242217
      WBVar00241805
      WBVar00241741
      WBVar00242222
      WBVar00241782
      WBVar00241797
      WBVar02148953
      WBVar02141306
      WBVar00241812
      WBVar00241809
      WBVar00239149
      WBVar00241656
      WBVar00089762
      WBVar00143595
      WBVar00242221
      WBVar00241818
      WBVar00242237
      WBVar00241783
      WBVar00241666
      WBVar00143732
      WBVar00239148
      WBVar00241811
      WBVar00241664
      WBVar00241875
      WBVar00241870
      WBVar00242218
      WBVar00241871
      WBVar00144596
      WBVar00241819
      WBVar00144788
      WBVar00241813
      WBVar00241808
      WBVar00241663
      WBVar00241791
      WBVar00242639
      WBVar00143108
      WBVar00241803
      WBVar00143103
      WBVar00239147
      WBVar00241690
      WBVar00241754
      WBVar00241693
      WBVar00241816
      WBVar00241689
      WBVar00089761
      WBVar00144789
      WBVar00248725
      WBVar00275407
      WBVar00241742
      WBVar00241781
      WBVar00143593
      WBVar00242240
      WBVar00143664
      WBVar00144397
      WBVar00143400
      WBVar00241794
      WBVar00143115
      WBVar00144611
      WBVar00241823
      WBVar00089760
      WBVar00242236
      WBVar00239145
      WBVar00241874
      WBVar00241671
      WBVar00242235
      WBVar00241787
      WBVar00241802
      WBVar00144619
      WBVar00241670
      WBVar00143542
      WBVar00241807
      WBVar00054397
      WBVar00241815
      WBVar02147718
      WBVar00241801
      WBVar00241788
      WBVar00241793
      WBVar00241667
      WBVar00241817
      WBVar00241668
      WBVar00241872
      WBVar00241669
      WBVar00241789
      WBVar00239153
      WBVar00143564
      WBVar00144597
      WBVar00275405
      WBVar00143594
      WBVar02157880
      WBVar02157881
      WBVar00946237
      WBVar01454403
      WBVar00946238
      WBVar01454404
      WBVar00946239
      WBVar01454405
      WBVar01846970
      WBVar00946240
      WBVar01454406
      WBVar00946241
      WBVar01454408
      WBVar00946242
      WBVar01454409
      WBVar01967088
      WBVar00946243
      WBVar01967089
      WBVar01454410
      WBVar01454411
      WBVar00946244
      WBVar01967090
      WBVar01454412
      WBVar00946245
      WBVar01967091
      WBVar01454413
      WBVar00946246
      WBVar00597664
      WBVar01454414
      WBVar00946247
      WBVar01454415
      WBVar01500079
      WBVar00946248
      WBVar01454416
      WBVar00192251
      WBVar00946249
      WBVar01495296
      WBVar00946250
      WBVar00192252
      WBVar01454417
      WBVar00946251
      WBVar01495297
      WBVar00192253
      WBVar00946252
      WBVar00192254
      WBVar00192255
      WBVar01482419
      WBVar00946253
      WBVar00192256
      WBVar00946254
      WBVar00192257
      WBVar00946255
      WBVar00192258
      WBVar00946256
      WBVar00946257
      WBVar00192259
      WBVar00946258
      WBVar00192260
      WBVar00946259
      WBVar00192261
      WBVar00946260
      WBVar00946261
      WBVar00946262
      WBVar01494756
      WBVar00946263
      WBVar00946080
      WBVar00946264
      WBVar00298725
      WBVar00946265
      WBVar00264645
      WBVar00946081
      WBVar00946266
      WBVar00315028
      WBVar00946082
      WBVar00946267
      WBVar00946083
      WBVar01498811
      WBVar00946268
      WBVar00946084
      WBVar00946085
      WBVar00946269
      WBVar01498996
      WBVar00946086
      WBVar00296621
      WBVar00946270
      WBVar00946271
      WBVar01498261
      WBVar01795605
      WBVar00946087
      WBVar00946088
      WBVar01795606
      WBVar02090085
      WBVar02079217
      WBVar00946272
      WBVar00946273
      WBVar00946089
      WBVar01795607
      WBVar00946274
      WBVar00946090
      WBVar00946091
      WBVar00946275
      WBVar00946276
      WBVar00946092
      WBVar00946093
      WBVar00946277
      WBVar00946094
      WBVar00946278
      WBVar00436981
      WBVar01499925
      WBVar00946279
      WBVar00436982
      WBVar00574438
      WBVar00946095
      WBVar00946096
      WBVar00436983
      WBVar00574440
      WBVar00946280
      WBVar00574445
      WBVar00946097
      WBVar00946281
      WBVar00436984
      WBVar01609475
      WBVar00436985
      WBVar00946282
      WBVar00946098
      WBVar00436986
      WBVar00946099
      WBVar00946283
      WBVar00946100
      WBVar00946284
      WBVar00436987
      WBVar00946101
      WBVar00261721
      WBVar00436988
      WBVar00946285
      WBVar00436989
      WBVar00261722
      WBVar00946286
      WBVar00946102
      WBVar00261723
      WBVar00946103
      WBVar00436990
      WBVar00946287
      WBVar00946104
      WBVar00436991
      WBVar00946288
      WBVar01688242
      WBVar00436992
      WBVar00946289
      WBVar00946105
      WBVar00946106
      WBVar00436993
      WBVar00946290
      WBVar00946291
      WBVar00436994
      WBVar00946107
      WBVar00946292
      WBVar00436995
      WBVar00946108
      WBVar00436996
      WBVar00946109
      WBVar00946293
      WBVar00946110
      WBVar00436997
      WBVar00946294
      WBVar00946111
      WBVar00436998
      WBVar00946295
      WBVar02071030
      WBVar00946112
      WBVar00946296
      WBVar00436999
      WBVar00437000
      WBVar00946113
      WBVar00946297
      WBVar00946298
      WBVar00946114
      WBVar00437001
      WBVar00946299
      WBVar00437002
      WBVar00946115
      WBVar00946116
      WBVar01581802
      WBVar00946300
      WBVar00437003
      WBVar00946301
      WBVar00946117
      WBVar00437004
      WBVar01581803
      WBVar00946302
      WBVar00946118
      WBVar00437005
      WBVar01492956
      WBVar00946303
      WBVar00946119
      WBVar00437006
      WBVar00946304
      WBVar00437007
      WBVar00946120
      WBVar00437008
      WBVar00946305
      WBVar00946121
      WBVar00946306
      WBVar00437009
      WBVar00946122
      WBVar00437010
      WBVar00946123
      WBVar00946307
      WBVar00946124
      WBVar00437011
      WBVar00946308
      WBVar00946125
      WBVar00946309
      WBVar00437012
      WBVar00946126
      WBVar00946310
      WBVar00437013
      WBVar00946127
      WBVar00946311
      WBVar00437014
      WBVar00946128
      WBVar00946312
      WBVar00437015
      WBVar00946313
      WBVar00946129
      WBVar00437016
      WBVar00266350
      WBVar00946314
      WBVar00437017
      WBVar00946130
      WBVar00946315
      WBVar00946131
      WBVar00437018
      WBVar00946316
      WBVar00437019
      WBVar00946132
      WBVar00437020
      WBVar02151872
      WBVar00946133
      WBVar00437021
      WBVar00946134
      WBVar00437022
      WBVar00946135
      WBVar00437023
      WBVar00946136
      WBVar00437024
      WBVar00946137
      WBVar00437025
      WBVar00946138
      WBVar00946139
      WBVar00437026
      WBVar00437027
      WBVar00946140
      WBVar00437028
      WBVar02047148
      WBVar00946141
      WBVar00437029
      WBVar00946142
      WBVar01904480
      WBVar00946143
      WBVar00437030
      WBVar00946144
      WBVar00437031
      WBVar00946145
      WBVar00437032
      WBVar00437033
      WBVar00946146
      WBVar01657303
      WBVar00946147
      WBVar00437034
      WBVar00946148
      WBVar00437035
      WBVar00946149
      WBVar00437036
      WBVar00437037
      WBVar00946150
      WBVar00946151
      WBVar00437038
      WBVar00437039
      WBVar00946152
      WBVar00437040
      WBVar00946153
      WBVar00437041
      WBVar00946154
      WBVar00278271
      WBVar00437042
      WBVar00946155
      WBVar00946156
      WBVar00278272
      WBVar00437043
      WBVar01494099
      WBVar00437044
      WBVar00278273
      WBVar00946157
      WBVar00946158
      WBVar00278274
      WBVar00437045
      WBVar00946159
      WBVar00437046
      WBVar00278275
      WBVar02115001
      WBVar01858888
      WBVar00946160
      WBVar00437047
      WBVar01858889
      WBVar00437048
      WBVar00946161
      WBVar01858890
      WBVar00437049
      WBVar00946162
      WBVar00437050
      WBVar00946163
      WBVar01858891
      WBVar00946164
      WBVar01858892
      WBVar00437051
      WBVar00946165
      WBVar00437052
      WBVar01858893
      WBVar00437053
      WBVar01858894
      WBVar00946166
      WBVar00300075
      WBVar01858895
      WBVar00946167
      WBVar00437054
      WBVar01858896
      WBVar00437055
      WBVar00946168
      WBVar00946169
      WBVar00437056
      WBVar01858897
      WBVar00946170
      WBVar00437057
      WBVar01858898
      WBVar00946171
      WBVar02059244
      WBVar00437058
      WBVar01858899
      WBVar01858900
      WBVar00437059
      WBVar02059245
      WBVar00946172
      WBVar01858901
      WBVar00946173
      WBVar02059246
      WBVar00437060
      WBVar01858902
      WBVar02059247
      WBVar00437061
      WBVar00946174
      WBVar01858903
      WBVar00437062
      WBVar00946175
      WBVar01858904
      WBVar00946176
      WBVar00437063
      WBVar00946177
      WBVar00437064
      WBVar01858905
      WBVar00946178
      WBVar00437065
      WBVar01858906
      WBVar00437066
      WBVar00946179
      WBVar01858907
      WBVar01858908
      WBVar00946180
      WBVar00437067
      WBVar01858909
      WBVar00946181
      WBVar00437068
      WBVar00248722
      WBVar01858910
      WBVar00946182
      WBVar00437069
      WBVar00437070
      WBVar01858911
      WBVar00946183
      WBVar01858912
      WBVar00946184
      WBVar00437071
      WBVar01858913
      WBVar00946185
      WBVar00437072
      WBVar00946186
      WBVar00437073
      WBVar01858914
      WBVar00946187
      WBVar01499650
      WBVar01858915
      WBVar00437074
      WBVar00437075
      WBVar01858916
      WBVar00946188
      WBVar01858917
      WBVar00437076
      WBVar00946189
      WBVar00437077
      WBVar00946190
      WBVar00946191
      WBVar00437078
      WBVar00437079
      WBVar00946192
      WBVar00437080
      WBVar00946193
      WBVar00437081
      WBVar00946194
      WBVar00437082
      WBVar00946195
      WBVar00946196
      WBVar00437083
      WBVar00946197
      WBVar00437084
      WBVar00946198
      WBVar00437085
      WBVar00597601
      WBVar02134767
      WBVar00946199
      WBVar00437086
      WBVar00946200
      WBVar00437087
      WBVar02021313
      WBVar02134768
      WBVar02134769
      WBVar00946201
      WBVar00437088
      WBVar02021314
      WBVar00437089
      WBVar00946202
      WBVar00946203
      WBVar00437090
      WBVar00437091
      WBVar00946204
      WBVar00437092
      WBVar00946205
      WBVar00437093
      WBVar00946206
      WBVar00602798
      WBVar00437094
      WBVar00946207
      WBVar00946208
      WBVar00946209
      WBVar00946210
      WBVar00946211
      WBVar02144031
      WBVar00946212
      WBVar00946213
      WBVar00946214
      WBVar00946215
      WBVar01731237
      WBVar00946216
      WBVar01731238
      WBVar00946217
      WBVar00946218
      WBVar01496368
      WBVar01731239
      WBVar02112298
      WBVar00946219
      WBVar01731240
      WBVar00946220
      WBVar00946221
      WBVar00946222
      WBVar00946223
      WBVar00946224
      WBVar02072444
      WBVar00946225
      WBVar00946226
      WBVar00946227
      WBVar00946228
      WBVar00946229
      WBVar00946230
      WBVar01500245
      WBVar00946231
      WBVar00946232
      WBVar01498775
      WBVar00946233
      WBVar01454400
      WBVar00946234
      WBVar01454401
      WBVar00946235
      WBVar01498779
      WBVar01454402
      WBVar00946236
    Legacy_information: e66 : twitcher at all stages; (moves slowly with constant trembling); thin; unable to hypercontract and therefore levamisole resistant; Egl; e66/+ twitches in 1% nicotine; ES3 ME0. NA > 200 (s32amber (resembles e66); m52dm; many Tc1 insertions etc.). Most unc-22/+ heterozygotes twitch in nicotine; abnormal muscle structure in most homozygotes; near normal muscle for alleles e105 s12 Tc1 induced alleles. See also unc-54.
      See also e66, e105, e308, e313, e320, e346, e640, e654, e682, e683, e691, e842, e855, e882, e913, e914, e915, e991, e1090, e1179, e1326, e1923, e2092, e2147, e2148, e2174, e2182, e2377, e2378, e2428, n789, n790, n791, n792, n793, s7, s8, s11, s12, s13, s14, s15, s16, s17, s18, s19, s20, s21, s22, s23, s24, s25, s28, s32, s34, s35, s36, s55, s56, s67, s135, s162, s164, s165, s183, s184, s264, s265, s266, s278, s279, s280, s281, s282, s283, s284, s285, s289, s292, s293, s294, s295, s296, s297, s298, s299, s300, s301, s302, s303, s304, s305, s306, s307, s308, s309, s310, s311, s312, s313, s314, s315, s316, s699, s700, s705, s724, s727, s1787, s1788, s1790, s1791, s1792, s1793, s2028, s2029, s2030, s2038, st136, st137, st192
      [C.elegansII] e66 : twitcher at all stages; (moves slowly with constant trembling); thin; abnormal muscle structure; unable to hypercontract and therefore levamisole resistant; Egl; e66/+ twitches in 1% nicotine; ES3 ME0. OA>200:s32amb (resembles e66), m52dm,e105 (muscle structure near normal),e2428, s7, s12 (near normal muscle structure),s2038,st192 etc. Many Tc1 insertions, plus precise and imprecise excision revertants. Most unc-22/+ heterozygotes twitch in nicotine. Cloned: large gene (>30 kb), transcript ~19 kb,encodes 6049 aa twitchin: single kinase domain, multiple copies of fibronectin-like and Ig-like repeats. Antibody staining indicates twitchin associated with thick filaments. [Waterston et al. 1980; Benian et al. 1989, 1993; GB]
    Strain (134)
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog (42)
    Paralog (12)
    Structured_description: Concise_description: unc-22 encodes twitchin, a giant intracellular protein with multiple fibronectin- and immunoglobulin-like domains and a single protein kinase domain that is homologous to titin (OMIM:188840); UNC-22 is required in muscle for regulation of the actomyosin contraction-relaxation cycle and for maintenance of normal muscle morphology; UNC-22 associates with myosin and is localized to A-bands; in vitro, UNC-22 can phosphorylate myosin light-chain peptides and can undergo autophosphorylation. Paper_evidence: WBPaper00001203
            WBPaper00001773
            WBPaper00005546
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including adult behavior; positive regulation of sarcomere organization; and positive regulation of striated muscle contraction. Located in A band. Expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2J; coronary artery disease; intrinsic cardiomyopathy (multiple); and tibial muscular dystrophy. Is an ortholog of human TTN (titin). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111188 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0110430 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0110283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0111078 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0110315 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0081341 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
  Molecular_info: Corresponding_CDS: ZK617.1a
      ZK617.1b
      ZK617.1c
      ZK617.1d
      ZK617.1e
      ZK617.1f
      ZK617.1g
      ZK617.1h
      ZK617.1i
    Corresponding_CDS_history: ZK617.1a:wp92
      ZK617.1b:wp92
      ZK617.1c:wp229
      ZK617.1d:wp243
      ZK617.1j:wp264
    Corresponding_transcript: ZK617.1a.1
      ZK617.1b.1
      ZK617.1c.1
      ZK617.1d.1
      ZK617.1e.1
      ZK617.1f.1
      ZK617.1g.1
      ZK617.1h.1
      ZK617.1i.1
    Other_sequence (86)
    Associated_feature (32)
  Experimental_info (8)
  Map_info: Map: IV Position: 5.45802 Error: 0.005203
    Well_ordered
    Positive: Inside_rearr: nDf28
        sDf8
      Positive_clone: LDM17
        YK1088
        ZK617 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: sDf22
        mDp4
    Mapping_data: 2_point (67)
      Multi_point (125)
      Pos_neg_data (38)
    Landmark_gene
  Reference (371)
  Remark: yk16f10.3 removed from sequence list. sdm 11/00
  Method: Gene