WormBase Tree Display for Gene: WBGene00011935

WBGene00011935 SMap: S_parent: Sequence: T22H2
  Identity: Version: 3
    Name: CGC_name: scrm-1 Paper_evidence: WBPaper00029228
          Person_evidence: WBPerson1606
      Sequence_name: T22H2.5
      Molecular_name: T22H2.5a
        T22H2.5a.1
        CE36204
        T22H2.5b
        CE36205
        T22H2.5c
        CE46345
        T22H2.5a.2
        T22H2.5b.1
        T22H2.5c.1
      Other_name: plsc-2 Person_evidence: WBPerson1626
        CELE_T22H2.5 Accession_evidence: NDB BX284601
      Public_name: scrm-1
    DB_info: Database: AceView gene 1M282
        WormQTL gene WBGene00011935
        WormFlux gene WBGene00011935
        NDB locus_tag CELE_T22H2.5
        Panther gene CAEEL|WormBase=WBGene00011935|UniProtKB=O45799
          family PTHR23248
        NCBI gene 173053
        RefSeq protein NM_001392951.1
            NM_001264776.4
            NM_060575.6
        TREEFAM TREEFAM_ID TF314939
        TrEMBL UniProtAcc G3MU68
            O45799
            Q7JKP1
        UniProt_GCRP UniProtAcc O45799
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 16 Oct 2006 17:00:28 WBPerson2970 Name_change: CGC_name: plsc-2
        3 03 May 2007 10:33:07 WBPerson2970 Name_change: CGC_name: scrm-1
                Other_name: plsc-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: scrm
    Allele: WBVar00674027
      WBVar00674028
      WBVar00674029
      WBVar00674030
      WBVar00674031
      WBVar00674032
      WBVar00674033
      WBVar00674034
      WBVar00674035
      WBVar01641169
      WBVar00674036
      WBVar00674037
      WBVar00674038
      WBVar01663668
      WBVar00674039
      WBVar01663669
      WBVar00674040
      WBVar00674041
      WBVar00674042
      WBVar00674043
      WBVar00674044
      WBVar00674045
      WBVar01346323
      WBVar00249728
      WBVar00305005
      WBVar01499739
      WBVar00249739
      WBVar02128582
      WBVar01993404
      WBVar00346495
      WBVar00346496
      WBVar00346497
      WBVar00346498
      WBVar01713372
      WBVar00346499
      WBVar00346500
      WBVar01713373
      WBVar01499788
      WBVar00346501
      WBVar01713374
      WBVar01499054
      WBVar00157605
      WBVar00157606
      WBVar00601759
      WBVar01499064
      WBVar00539725
      WBVar00539726
      WBVar00539727
      WBVar01574121
      WBVar00249833
      WBVar00249847
      WBVar00249852
      WBVar02016483
      WBVar01285348
      WBVar01498959
    Strain: WBStrain00005192
      WBStrain00005193
      WBStrain00047218
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (54)
    Paralog: WBGene00008681 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009753 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00014200 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00015437 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019530 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019531 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013052 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00235369 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: scrm-1 encodes, by alternative splicing, two isoforms of a putativephospholipid scramblase required for phosphatidylserine exposure and thenormally rapid engulfment of apoptotic cells in the germline; SCRM-1 islocalized to plasma membranes of embryonic cells from earlyembryogenesis onward; SCRM-1 is specifically bound by residues 380-550of WAH-1 in vitro, and WAH-1 binding is required in liposomes for morethan residual SCRM-1 activity; in scrm-1(tm698) or scrm-1(tm805)embryos, apoptotic cells do eventually disappear, but their removal isdelayed; SCRM-1 is homologous to human PLSCR1-5, and paralogous toSCRM-2 through SCRM-8. Paper_evidence: WBPaper00004911
            WBPaper00012809
            WBPaper00013208
            WBPaper00013590
            WBPaper00029228
          Curator_confirmed: WBPerson567
          Date_last_updated: 16 May 2007 00:00:00
      Automated_description: Enables phospholipid scramblase activity. Involved in phosphatidylserine exposure on apoptotic cell surface. Located in plasma membrane. Expressed in several structures, including germ line. Is an ortholog of several human genes including PLSCR2 (phospholipid scramblase 2); PLSCR3 (phospholipid scramblase 3); and PLSCR4 (phospholipid scramblase 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T22H2.5a
      T22H2.5b
      T22H2.5c
    Corresponding_CDS_history: T22H2.5a:wp114
      T22H2.5b:wp114
    Corresponding_transcript: T22H2.5a.1
      T22H2.5a.2
      T22H2.5b.1
      T22H2.5c.1
    Other_sequence: NBC07936_1
      DN190196.1
      Oden_isotig20045
      NB06820
      CBC00339_1
      Oden_isotig22603
      Acan_isotig11840
      Oden_isotig22385
      AAC00108_1
    Associated_feature: WBsf716505
      WBsf985363
      WBsf985364
      WBsf1010769
      WBsf220359
  Experimental_info: RNAi_result (16)
    Expr_pattern: Expr4579
      Expr1010600
      Expr1035267
      Expr1157415
      Expr2015650
      Expr2033882
    Antibody: WBAntibody00001243
    Microarray_results (30)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056284:ints-6(t1903)_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056826:SGP_biased
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00059987:Wounding_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:B
      WBPaper00061340:Rectal_cell
      WBPaper00061340:RMED
      WBPaper00061340:Y
      WBPaper00061466:nath-10(icb99)_downregulated
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:snt-4_17845-T27C4.1
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064952:Day10_vs_L4_upregulated_25C
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00034661:AgNPs_upregulated
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00037695:WC_5-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038231:Cry5B_2-fold_upregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:TA200_down
      WBPaper00040963:TA300_down
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00044535:male_upregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
    Interaction (92)
  Map_info: Map: I Position: 9.56187 Error: 0.004742
    Positive: Positive_clone: T22H2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene