gpx-1 encodes a phospholipid hydroperoxide glutathione peroxidase; GPX-1 is predicted to catalyze the reduction of phospholipid hydroperoxides with glutathione; loss of gpx-1 activity via RNAi results in increased intestinal dipeptide uptake and increased cellular levels of the unsaturated aldehyde 4-hydroxynonenal (4-HNE), a lipid peroxidation product.
Enables phospholipid-hydroperoxide glutathione peroxidase activity. Involved in cellular response to reactive oxygen species and regulation of peptide transport. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and spondylometaphyseal dysplasia Sedaghatian type. Is an ortholog of human GPX4 (glutathione peroxidase 4).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.