WormBase Tree Display for Gene: WBGene00006890

WBGene00006890 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: K07E3
  Identity: Version: 1
    Name: CGC_name: vem-1 Person_evidence: WBPerson1835
      Sequence_name: K07E3.8
      Molecular_name: K07E3.8
        K07E3.8.1
        CE34578
      Other_name: CELE_K07E3.8 Accession_evidence: NDB BX284606
      Public_name: vem-1
    DB_info: Database: AceView gene XI706
        WormQTL gene WBGene00006890
        WormFlux gene WBGene00006890
        NDB locus_tag CELE_K07E3.8
        Panther gene CAEEL|WormBase=WBGene00006890|UniProtKB=Q7YZW5
          family PTHR10281
        NCBI gene 181066
        RefSeq protein NM_001029599.11
        SwissProt UniProtAcc Q7YZW5
        UniProt_GCRP UniProtAcc Q7YZW5
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vem
    Allele: WBVar00599144
      WBVar01981044
      WBVar01884644
      WBVar01499781
      WBVar02151886
      WBVar00146307
      WBVar00092327
      WBVar01499642
      WBVar01500012
      WBVar01500013
      WBVar00241652
      WBVar00509944
      WBVar00509945
      WBVar00509946
      WBVar00509947
      WBVar00509948
      WBVar00509949
      WBVar00509950
      WBVar00509951
      WBVar00509952
      WBVar00081078
      WBVar01816162
      WBVar01165200
      WBVar01165201
      WBVar01165202
      WBVar01165203
      WBVar01165204
      WBVar01165205
      WBVar01165206
      WBVar01165207
      WBVar01165208
      WBVar01498960
      WBVar00145627
      WBVar01500067
    Strain: WBStrain00035774
      WBStrain00035993
    RNASeq_FPKM (74)
    GO_annotation: 00082942
      00082943
      00082944
      00082945
      00082946
      00082947
      00082948
      00082949
      00082950
      00082951
    Ortholog (41)
    Paralog: WBGene00006478 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012559 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: vem-1 encodes a transmembrane protein that contains a cytochrome b5-like heme/steroid-binding domain and is orthologous to mammalian VEMA, a membrane-associated progesterone receptor component; in C. elegans, vem-1 is required for proper axonal guidance of ventral nerve cord neurons; vem-1 interacts genetically with unc-40, whose protein product also interacts with VEM-1; a VEM-1::GFP reporter fusion is expressed from embryonic stages through late larval stages and is found in a subset of neurons, including the AVG pioneer neurons, that extend processes into the ventral nerve cord; microarray experiments indicate that vem-1 transcripts are upregulated in response to treatment with xenobiotics such as clofibrate and beta-naphthoflavone. Paper_evidence: WBPaper00024484
            WBPaper00026820
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Feb 2009 00:00:00
      Automated_description: Involved in innate immune response. Located in axon. Expressed in AVG; head neurons; and somatic nervous system. Is an ortholog of human PGRMC1 (progesterone receptor membrane component 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K07E3.8
    Corresponding_CDS_history: K07E3.8a:wp252
    Corresponding_transcript: K07E3.8.1
    Other_sequence (28)
    Associated_feature: WBsf654188
      WBsf654189
      WBsf654190
      WBsf654191
      WBsf670808
      WBsf982206
      WBsf1006049
  Experimental_info: RNAi_result: WBRNAi00061111 Inferred_automatically: RNAi_primary
      WBRNAi00050171 Inferred_automatically: RNAi_primary
      WBRNAi00061112 Inferred_automatically: RNAi_primary
      WBRNAi00016735 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3106
      Expr1011310
      Expr1032922
      Expr1153866
      Expr2017966
      Expr2036102
    Drives_construct: WBCnstr00001989
      WBCnstr00034111
    Construct_product: WBCnstr00034111
    Microarray_results (22)
    Expression_cluster: WBPaper00032528:L3_enriched
      WBPaper00032976:non_compensated_genes
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Oogenic
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00048926:miaserin_upregulated_adult-day3
      WBPaper00048926:miaserin_upregulated_adult-day5
      WBPaper00048926:miaserin_upregulated_adult-day10
      WBPaper00048988:neuron_expressed
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050561:indole_10-fold_upregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00056073:NHR-86_interacting_promoter
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058599:benzimidazoles_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061340:AMsh
      WBPaper00061340:ant_arc_V
      WBPaper00061340:hyp1V_and_ant_arc_V
      WBPaper00061340:T
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:vem-1-ugt-58
      WBPaper00061590:CGP37157_upregulated
      WBPaper00061651:BAG_enriched
      WBPaper00061651:PHsh_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062237:dnj-21(RNAi)_upregulated_protein
      WBPaper00062293:isp-1(qm150)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064291:antimycin_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064788:ketamine_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065841:15_0
      WBPaper00065841:21_0
      WBPaper00065841:21_1
      WBPaper00065841:85_0
      WBPaper00065849:ursolic-acid_regulated
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028482:PA14_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00036286:Pattern_I
      WBPaper00037113:CPF_16C_up-regulated
      WBPaper00037704:ABZ_up_regulated
      WBPaper00038427:lin-54_germline_changed
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00041211:RPW-24_Up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_3h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00050407:hsp-6(RNAi)_upregulated
      WBPaper00055899:2,4-Dinitroanisole_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc5976]:class_1
    Interaction (20)
  Map_info: Map: X Position: -0.581887 Error: 0.008927
    Positive: Positive_clone: K07E3 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4259
        4404
        4750
    Pseudo_map_position
  Reference: WBPaper00018032
    WBPaper00024484
    WBPaper00026820
    WBPaper00033099
    WBPaper00038491
    WBPaper00048021
    WBPaper00050498
    WBPaper00055090
  Remark: Sequence connection from [Runko E, Kaprielian Z]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene