WormBase Tree Display for Variation: WBVar00000007

WBVar00000007 Evidence: Author_evidence: Curtis L
  Name: Public_name: ad446
    HGVSg: CHROMOSOME_III:g.5612625_5616891delinsAAAAAA
  Sequence_details: SMap: S_parent: Sequence: C05D2
    Flanking_sequences: agactgggcaaaaatctttgacgatctcgaaaatgtggtggtgaa aaaatacaaaataatgaagtaggcacgtgtatgtaggcag
    Mapping_target: C05D2
    Type_of_mutation: Insertion: aaaaaa
      Deletion
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00027310
      WBStrain00027351
    Laboratory: DA
    Status: Live
  Affects: Gene: WBGene00015467
      WBGene00000239
    Transcript: C05D2.4b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        cDNA_position: 213-?
        CDS_position: 198-?
        Protein_position: 66-?
        Intron_number: 3-8/9
        Exon_number: 3-10/10
      C05D2.3.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        Intron_number: 2-7/9
        Exon_number: 1-7/10
      C05D2.4a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        cDNA_position: 213-?
        CDS_position: 198-?
        Protein_position: 66-?
        Intron_number: 3-7/8
        Exon_number: 3-9/9
    Interactor: WBInteraction000500584
  Isolation: Mutagen: EMS
    Forward_genetics: standard phenotypic screen
  Genetics: Interpolated_map_position: III -1.46914
    Mapping_data: In_multi_point: 2312
        2693
  Description: Phenotype (23)
    Phenotype_not_observed: WBPhenotype:0000039 Paper_evidence: WBPaper00040570
        Curator_confirmed: WBPerson8126
        Remark: Fig.1 (lifespan extension upon reserpine treatment, not different from wild type) Paper_evidence: WBPaper00040570
            Curator_confirmed: WBPerson8126
        Affected_by: Molecule: WBMol:00002955 Paper_evidence: WBPaper00040570
              Curator_confirmed: WBPerson8126
      WBPhenotype:0001101 Paper_evidence: WBPaper00038382
        Curator_confirmed: WBPerson712
        Remark: Clozapine-induced increases in egg laying was present. Paper_evidence: WBPaper00038382
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003634 Paper_evidence: WBPaper00038382
              Curator_confirmed: WBPerson712
      WBPhenotype:0001765 Paper_evidence: WBPaper00031936
        Curator_confirmed: WBPerson2021
        Remark: Mutants defective in the synthesis and reception of nonessential excitatory neurotransmitters respond normally to CO2 Paper_evidence: WBPaper00031936
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00031936
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 10% CO2 Paper_evidence: WBPaper00031936
              Curator_confirmed: WBPerson2021
  Disease_info: Models_disease: DOID:809
      DOID:0050742
    Models_disease_in_annotation: WBDOannot00000679
      WBDOannot00000680
  Reference: WBPaper00038382
    WBPaper00040570
    WBPaper00043908
    WBPaper00031936
    WBPaper00032335
    WBPaper00011911
    WBPaper00001861
    WBPaper00014504
    WBPaper00015782
  Method: Deletion_and_insertion_allele