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WormBase Tree Display for Variation: WBVar00000007

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Name Class

WBVar00000007EvidenceAuthor_evidenceCurtis L
NamePublic_namead446
HGVSgCHROMOSOME_III:g.5612625_5616891delinsAAAAAA
Sequence_detailsSMapS_parentSequenceC05D2
Flanking_sequencesagactgggcaaaaatctttgacgatctcgaaaatgtggtggtgaaaaaatacaaaataatgaagtaggcacgtgtatgtaggcag
Mapping_targetC05D2
Type_of_mutationInsertionaaaaaa
Deletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00027310
WBStrain00027351
LaboratoryDA
StatusLive
AffectsGeneWBGene00015467
WBGene00000239
TranscriptC05D2.4b.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
cDNA_position213-?
CDS_position198-?
Protein_position66-?
Intron_number3-8/9
Exon_number3-10/10
C05D2.3.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
VEP_impactHIGH
Intron_number2-7/9
Exon_number1-7/10
C05D2.4a.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
cDNA_position213-?
CDS_position198-?
Protein_position66-?
Intron_number3-7/8
Exon_number3-9/9
InteractorWBInteraction000500584
IsolationMutagenEMS
Forward_geneticsstandard phenotypic screen
GeneticsInterpolated_map_positionIII-1.46914
Mapping_dataIn_multi_point2312
2693
DescriptionPhenotypeWBPhenotype:0000164Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000224Person_evidenceWBPerson384
WBPerson261
Curator_confirmedWBPerson48
WBPerson712
RemarkLow levels of serotonin immunoreactivity seen; possibly not genuine serotonin.Person_evidenceWBPerson384
Curator_confirmedWBPerson48
serotonin-deficient (no detectable serotonin immunoreactivity); serotonin immunoreactivity restored by exposure to serotonin, but not to 5-hydroxytryptophan; poor male turning behaviorPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
PenetranceCompletePerson_evidenceWBPerson384
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson384
Curator_confirmedWBPerson48
Variation_effectNullPerson_evidenceWBPerson384
Curator_confirmedWBPerson48
WBPhenotype:0000227Paper_evidenceWBPaper00001861
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkSimilar to cat-4 male turning defective, <40% good turns, frequent sloppy or missed turns. No males were perfect e.g. made good turns 100% of the time.Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
poor male turning behaviorPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
WBPhenotype:0000234Person_evidenceWBPerson384
Curator_confirmedWBPerson48
PenetranceCompletePerson_evidenceWBPerson384
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson384
Curator_confirmedWBPerson48
Variation_effectNullPerson_evidenceWBPerson384
Curator_confirmedWBPerson48
WBPhenotype:0000424Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
RemarkNo serotonin-IR (immunoreactivity), can be restored by treatment with serotonin, but not its precursor, 5-HTP.Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
WBPhenotype:0000648Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
RemarkMutant males seem to be unable to "track" the hermaphrodite after contact, lose contact altogether, have difficulty escaping from spontaneous dorsal inward tail coils, and are more likely to ignore contact with a hermaphrodite.Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00001861
Curator_confirmedWBPerson712
WBPhenotype:0001005Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0001444Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
RemarkAnimals exhibited defective gustatory plasticity of NaCl.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested for response to 25 mM NaCl after various pre-treatments: a 15-min wash in CTX buffer with or without 100 mM NaCl (liquid), or 30 min on a CTX plate with or without 100 mM NaCl, and in the presence or absence of bacteria, 500 mM glycerol, or 3 uL of benzaldehyde.Paper_evidenceWBPaper00032335
Curator_confirmedWBPerson712
WBPhenotype:0002284Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002289Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002293Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002295Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002300Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002303Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002309Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002312Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002319Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002322Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002325Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002328Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002337Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002346Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0004023Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000039Paper_evidenceWBPaper00040570
Curator_confirmedWBPerson8126
RemarkFig.1 (lifespan extension upon reserpine treatment, not different from wild type)Paper_evidenceWBPaper00040570
Curator_confirmedWBPerson8126
Affected_byMoleculeWBMol:00002955Paper_evidenceWBPaper00040570
Curator_confirmedWBPerson8126
WBPhenotype:0001101Paper_evidenceWBPaper00038382
Curator_confirmedWBPerson712
RemarkClozapine-induced increases in egg laying was present.Paper_evidenceWBPaper00038382
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003634Paper_evidenceWBPaper00038382
Curator_confirmedWBPerson712
WBPhenotype:0001765Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
RemarkMutants defective in the synthesis and reception of nonessential excitatory neurotransmitters respond normally to CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Phenotype_assayTreatment10% CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Disease_infoModels_diseaseDOID:809
DOID:0050742
Models_disease_in_annotationWBDOannot00000679
WBDOannot00000680
ReferenceWBPaper00038382
WBPaper00040570
WBPaper00043908
WBPaper00031936
WBPaper00032335
WBPaper00011911
WBPaper00001861
WBPaper00014504
WBPaper00015782
MethodDeletion_and_insertion_allele