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WormBase Tree Display for Gene: WBGene00022727

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Name Class

WBGene00022727SMapS_parentSequenceZK381
IdentityVersion3
NameCGC_nameprkl-1Person_evidenceWBPerson114
Sequence_nameZK381.5
Molecular_nameZK381.5a
ZK381.5a.1
CE41743
ZK381.5b
CE41744
ZK381.5b.1
Other_namende-2Paper_evidenceWBPaper00049708
CELE_ZK381.5Accession_evidenceNDBBX284604
Public_nameprkl-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:06WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
215 Mar 2007 17:00:31WBPerson2970Name_changeCGC_nameprkl-1
302 Aug 2016 10:45:57WBPerson2970Name_changeOther_namende-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classprkl
Allele (100)
StrainWBStrain00030530
WBStrain00033022
RNASeq_FPKM (74)
GO_annotation00005326
00126723
Ortholog (47)
ParalogWBGene00004112Caenorhabditis elegansFrom_analysisPanther
WBGene00015217Caenorhabditis elegansFrom_analysisTreeFam
Panther
Structured_descriptionConcise_descriptionprkl-1 encodes a homolog of Drosophila ESPINAS and PRICKLE, and of humanPRICKLE1, PRICKLE2, and LMO6; prkl-1 enables Wnt-directed planar cellpolarity; prkl-1 is required for the fully asymmetrical division of B.aversus B.p cells, though this requirement is quantitatively weak.Paper_evidenceWBPaper00027345
Curator_confirmedWBPerson567
Date_last_updated25 Oct 2006 00:00:00
Automated_descriptionPredicted to enable zinc ion binding activity. Expressed in several structures, including QL; egg-laying apparatus; gonad; head; and somatic nervous system. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Is an ortholog of human PRICKLE2 (prickle planar cell polarity protein 2) and PRICKLE3 (prickle planar cell polarity protein 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111448Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17019)
Molecular_infoCorresponding_CDSZK381.5a
ZK381.5b
Corresponding_CDS_historyZK381.5:wp83
ZK381.5a:wp183
ZK381.5b:wp183
Corresponding_transcriptZK381.5a.1
ZK381.5b.1
Other_sequenceBMC13568_1
JI171960.1
BM01268
Associated_feature (14)
Transcription_factorWBTranscriptionFactor000259
Experimental_infoRNAi_result (21)
Expr_pattern (11)
Drives_constructWBCnstr00002499
WBCnstr00002500
WBCnstr00009089
WBCnstr00009093
WBCnstr00014217
WBCnstr00024021
Construct_productWBCnstr00009089
WBCnstr00009097
WBCnstr00009098
WBCnstr00009099
WBCnstr00023141
WBCnstr00024021
Microarray_results (30)
Expression_clusterWBPaper00029359_1124
WBPaper00029359_1141
WBPaper00029359_1280
WBPaper00029359_1304
WBPaper00029359_1351
WBPaper00029359_1444
WBPaper00029359_1497
WBPaper00029359_1504
WBPaper00029359_1525
WBPaper00029359_1604
WBPaper00033065:clk-1(qm30)_upregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035197:fer-1_downregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00041222:unc-120(st364)_downregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044316:CH3HgCl_7.5uM_downregulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00045257:bar-1(ga80)_downregulated
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00045521:Gender_Neutral
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00050094:mes-2(bn11)_upregulated
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050743:elli-1(sam-3)_upregulated
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:intestine_expressed
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00051404:alg-1(gk214)_downregulated
WBPaper00051558:aging_regulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055013:hmg-4(RNAi)_downregulated
WBPaper00055013:spt-16(RNAi)_downregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055648:male-vas-deferens_expressed
WBPaper00056039:ptl-1(ok621)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056167:Cry5B_upregulated
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056284:ints-1(RNAi)_downregulated
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056826:hmc_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060526:plp-1(ok2155)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:ALM_BDU
WBPaper00061340:DA
WBPaper00061340:DB
WBPaper00061340:DD
WBPaper00061340:Glia
WBPaper00061340:I5
WBPaper00061340:mc2
WBPaper00061340:mc3
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:mu_sph
WBPaper00061340:Z1_Z4
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061479:hda-1(ne4748)_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061527:cfz-2_18944-cfz-2_2268
WBPaper00061527:dsh-1_3575-C40A11.4
WBPaper00061651:VC_4_5_enriched
WBPaper00061902:camt-1(ok515)_regulated_AFD
WBPaper00062095:unc-4(e120)_upregulated_VA-neuron
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062184:PA14_downregulated
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062590:Aging_downregulated_neuron
WBPaper00062672:dcp-66(RNAi)_upregulated
WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064539:nhr-114(gk849)_downregulated
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00065029:cadmium_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065258:anchor-cell_enriched
WBPaper00065331:100nM-ivermectin_downregulated
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065841:6_3
WBPaper00065841:37_0
WBPaper00065841:68_0
WBPaper00065841:98_0
WBPaper00065841:102_0
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4386_cluster_6_4
cgc4489_group_18
cgc4489_group_19
cgc4489_group_23
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_N2
WBPaper00027111:rrf-3(pk1426)_downregulated
WBPaper00029437:dcr-1_upregulated
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00034661:AgNPs_downregulated
WBPaper00035227:heat_shock_regulated
WBPaper00036130:mir-243_up_regulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_aging
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040858:eQTL_regulated_old
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00041174:environmental
WBPaper00041174:genotypic
WBPaper00041174:genotypic_and_environmental
WBPaper00041939:control_vs_UVC-exposed_3h
WBPaper00045673:colistin_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:N2_allantoin_upregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
Interaction (78)
Map_infoMapIVPosition3.27518Error0.000766
PositivePositive_cloneZK381Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (18)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene