| WBGene00020142 | SMap | S_parent | Sequence | T01C8 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | aak-2 | Paper_evidence | WBPaper00024628 |
| | | Sequence_name | T01C8.1 |
| | | Molecular_name | T01C8.1a |
| | | | T01C8.1a.1 |
| | | | CE31222 |
| | | | T01C8.1b |
| | | | CE31223 |
| | | | T01C8.1c |
| | | | CE07458 |
| | | | T01C8.1b.1 |
| | | | T01C8.1c.1 |
| | | Other_name | AMPK | Paper_evidence | WBPaper00035954 |
| | | | CELE_T01C8.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | aak-2 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 25 Jan 2005 16:32:44 | WBPerson2970 | Name_change | CGC_name | aak-2 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | aak |
| | Allele (112) |
| | Possibly_affected_by | WBVar02157821 |
| | | WBVar02157822 |
| | Strain (12) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00090156 |
| | | 00090157 |
| | | 00090158 |
| | | 00090159 |
| | | 00090160 |
| | | 00090161 |
| | | 00090162 |
| | | 00090163 |
| | | 00090164 |
| | | 00090165 |
| | | 00090166 |
| | | 00090167 |
| | | 00090168 |
| | | 00090169 |
| | | 00090170 |
| | | 00090171 |
| | | 00090172 |
| | | 00090173 |
| | | 00090174 |
| | | 00090175 |
| | | 00090176 |
| | | 00090177 |
| | | 00090178 |
| | | 00090179 |
| | | 00090180 |
| | | 00090181 |
| | | 00124850 |
| | | 00124851 |
| | | 00124852 |
| | Ortholog (39) |
| | Paralog (19) |
| | Structured_description | Concise_description | aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide. | Paper_evidence | WBPaper00024886 |
| | | | | | WBPaper00027027 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 08 Mar 2006 00:00:00 |
| | | Automated_description | Enables AMP-activated protein kinase activity. Involved in several processes, including determination of adult lifespan; pharyngeal pumping; and regulation of protein secretion. Located in axon; cytoplasm; and neuronal cell body. Expressed in several structures, including body wall musculature; excretory canal; interfacial epithelial cell; neurons; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; colon cancer; and type 2 diabetes mellitus. Is an ortholog of human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) and PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9376) |
| | | DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9376) |
| | | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9377) |
| | | DOID:219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9376) |
| | | DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9376) |
| Molecular_info | Corresponding_CDS | T01C8.1a |
| | | T01C8.1b |
| | | T01C8.1c |
| | Corresponding_transcript | T01C8.1a.1 |
| | | T01C8.1b.1 |
| | | T01C8.1c.1 |
| | Other_sequence (78) |
| | Associated_feature (15) |
| Experimental_info | RNAi_result (34) |
| | Expr_pattern (15) |
| | Drives_construct (17) |
| | Construct_product (28) |
| | Regulate_expr_cluster | WBPaper00038118:aak-2(gt33)_downregulated |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038172:aak-2overexpression_down_regulated |
| | | WBPaper00038172:aak-2overexpression_up_regulated |
| | | WBPaper00046499:AMPK_regulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | Microarray_results (31) |
| | Expression_cluster | WBPaper00032031:DConiospora_downregulated_cDNA_12h |
| | | WBPaper00034761:hlh-30_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:coelomocytes_embryo_enriched |
| | | WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched |
| | | WBPaper00037950:excretory-cell_larva_enriched |
| | | WBPaper00037950:excretory-cell_larva_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00054626:NO_upregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:trcs-2_5724-R11A8.7_17645 |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064532:pals-25(icb98)_downregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066085:sin-3(syb2172)_upregulated |
| | | cgc4386_cluster_5_5 |
| | | cgc4489_group_14 |
| | | WBPaper00025032:cluster_111 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030985:Erwinia_carotovora_upregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00038427:lin-54_germline_changed |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041960:daf-16_fasting_upregulated |
| | | WBPaper00041960:jun-1_fasting_upregulated |
| | | WBPaper00041960:kgb-1_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00050538:Fasting_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(143_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(143_min) |
| | Interaction (171) |
| | Anatomy_function | WBbtf0654 |
| | | WBbtf0655 |
| | | WBbtf0658 |
| | WBProcess | WBbiopr:00000121 |
| Map_info | Map | X | Position | 24.0613 | Error | 0.00069 |
| | Positive | Positive_clone | T01C8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5059 |
| | | | 4398 |
| | Pseudo_map_position |
| Reference (233) |
| Picture | WBPicture0000013096 |
| | WBPicture0000013098 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
