WormBase Tree Display for Gene: WBGene00018811
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| WBGene00018811 | SMap | S_parent | Sequence | F54D11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pmt-2 | Person_evidence | WBPerson888 | |||||
| Sequence_name | F54D11.1 | ||||||||
| Molecular_name | F54D11.1 | ||||||||
| F54D11.1.1 | |||||||||
| CE11068 | |||||||||
| Other_name | CELE_F54D11.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | pmt-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 19 May 2006 11:42:44 | WBPerson2970 | Name_change | CGC_name | pmt-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pmt | ||||||||
| Allele (90) | |||||||||
| Strain | WBStrain00036988 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00044310 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00000765 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008743 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015450 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019198 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019675 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019961 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019963 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019968 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022781 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | pmt-2 encodes an experimentally validated N-methyltransferase required for phosphocholine biosynthesis and viability; PMT-2 lacks known mammalian orthologs, but has orthologs in parasitic nematodes, fish, amphibians, echinoderms, plants, alveolata, and bacteria; PMT-2 is distantly paralogous to PMT-1; PMT-2 has a single C-terminal methyltransferase domain, unlike plant enzymes that have two tandem domains, and catalyses only two of three steps in phosphocholine biosynthesis (methylation of phosphomonomethylethanolamine [P-MME] to phosphodimethylethanolamine [P-DME] and of P-DME to phosphocholine, but not methylation of phosphoethanolamine to P-MME); pmt-2(RNAi) animals are unable to progress past the L1 larval stage, but can be rescued by choline in their food media; PMT-2 binds its substrates in random order, and is competitively inhibited by phosphocholine; given its phylogenetic and enzymatic specificity, coupled with its inviable RNAi phenotype, PMT-1 is a plausible target for nematicides. | Paper_evidence | WBPaper00027622 | |||||
| WBPaper00029127 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 24 Jul 2007 00:00:00 | ||||||||
| Automated_description | Enables phosphatidyl-N-dimethylethanolamine N-methyltransferase activity and phosphatidyl-N-methylethanolamine N-methyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Is an ortholog of human TMT1A (thiol methyltransferase 1A) and TMT1B (thiol methyltransferase 1B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F54D11.1 | |||||||
| Corresponding_transcript | F54D11.1.1 | ||||||||
| Other_sequence (76) | |||||||||
| Associated_feature | WBsf646766 | ||||||||
| WBsf999839 | |||||||||
| WBsf999840 | |||||||||
| WBsf1019526 | |||||||||
| WBsf1019527 | |||||||||
| WBsf231676 | |||||||||
| WBsf231677 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00112534 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00117411 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00117409 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00117407 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00048294 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084628 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00117405 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084627 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084630 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084629 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1028910 | ||||||||
| Expr1038113 | |||||||||
| Expr1152094 | |||||||||
| Expr2014980 | |||||||||
| Expr2033215 | |||||||||
| Regulate_expr_cluster | WBPaper00055482:pmt-2(RNAi)_downregulated | ||||||||
| WBPaper00055482:pmt-2(RNAi)_upregulated | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (244) | |||||||||
| Interaction (103) | |||||||||
| Map_info | Map | V | Position | -4.91265 | Error | 0.038419 | |||
| Positive | Positive_clone | F54D11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00027622 | ||||||||
| WBPaper00029012 | |||||||||
| WBPaper00029127 | |||||||||
| WBPaper00043645 | |||||||||
| WBPaper00044448 | |||||||||
| WBPaper00048598 | |||||||||
| WBPaper00050085 | |||||||||
| WBPaper00060431 | |||||||||
| WBPaper00062390 | |||||||||
| WBPaper00064105 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
