WormBase Tree Display for Gene: WBGene00018811
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WBGene00018811 | SMap | S_parent | Sequence | F54D11 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | pmt-2 | Person_evidence | WBPerson888 | |||
Sequence_name | F54D11.1 | ||||||
Molecular_name | F54D11.1 | ||||||
F54D11.1.1 | |||||||
CE11068 | |||||||
Other_name | CELE_F54D11.1 | Accession_evidence | NDB | BX284605 | |||
Public_name | pmt-2 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pmt | ||||||
Allele (90) | |||||||
Strain | WBStrain00036988 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (14) | |||||||
Ortholog (39) | |||||||
Paralog | WBGene00044310 | Caenorhabditis elegans | From_analysis | Panther | |||
WBGene00000765 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00008743 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00015450 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019198 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019675 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019961 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019963 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019968 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00022781 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | pmt-2 encodes an experimentally validated N-methyltransferase required for phosphocholine biosynthesis and viability; PMT-2 lacks known mammalian orthologs, but has orthologs in parasitic nematodes, fish, amphibians, echinoderms, plants, alveolata, and bacteria; PMT-2 is distantly paralogous to PMT-1; PMT-2 has a single C-terminal methyltransferase domain, unlike plant enzymes that have two tandem domains, and catalyses only two of three steps in phosphocholine biosynthesis (methylation of phosphomonomethylethanolamine [P-MME] to phosphodimethylethanolamine [P-DME] and of P-DME to phosphocholine, but not methylation of phosphoethanolamine to P-MME); pmt-2(RNAi) animals are unable to progress past the L1 larval stage, but can be rescued by choline in their food media; PMT-2 binds its substrates in random order, and is competitively inhibited by phosphocholine; given its phylogenetic and enzymatic specificity, coupled with its inviable RNAi phenotype, PMT-1 is a plausible target for nematicides. | Paper_evidence | WBPaper00027622 | |||
WBPaper00029127 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 24 Jul 2007 00:00:00 | ||||||
Automated_description | Enables phosphatidyl-N-dimethylethanolamine N-methyltransferase activity and phosphatidyl-N-methylethanolamine N-methyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Is an ortholog of human TMT1A (thiol methyltransferase 1A) and TMT1B (thiol methyltransferase 1B). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | F54D11.1 | |||||
Corresponding_transcript | F54D11.1.1 | ||||||
Other_sequence (76) | |||||||
Associated_feature | WBsf646766 | ||||||
WBsf999839 | |||||||
WBsf999840 | |||||||
WBsf1019526 | |||||||
WBsf1019527 | |||||||
WBsf231676 | |||||||
WBsf231677 | |||||||
Experimental_info | RNAi_result | WBRNAi00112534 | Inferred_automatically | RNAi_primary | |||
WBRNAi00117411 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00117409 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00117407 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00048294 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084628 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00117405 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084627 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084630 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084629 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1028910 | ||||||
Expr1038113 | |||||||
Expr1152094 | |||||||
Expr2014980 | |||||||
Expr2033215 | |||||||
Regulate_expr_cluster | WBPaper00055482:pmt-2(RNAi)_downregulated | ||||||
WBPaper00055482:pmt-2(RNAi)_upregulated | |||||||
Microarray_results (20) | |||||||
Expression_cluster (244) | |||||||
Interaction (103) | |||||||
Map_info | Map | V | Position | -4.91265 | Error | 0.038419 | |
Positive | Positive_clone | F54D11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00027622 | ||||||
WBPaper00029012 | |||||||
WBPaper00029127 | |||||||
WBPaper00043645 | |||||||
WBPaper00044448 | |||||||
WBPaper00048598 | |||||||
WBPaper00050085 | |||||||
WBPaper00060431 | |||||||
WBPaper00062390 | |||||||
WBPaper00064105 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |