WormBase Tree Display for Gene: WBGene00022781
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| WBGene00022781 | SMap | S_parent | Sequence | ZK622 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pmt-1 | Person_evidence | WBPerson888 | |||||
| Sequence_name | ZK622.3 | ||||||||
| Molecular_name (14) | |||||||||
| Other_name | phi-40 | Person_evidence | WBPerson2582 | ||||||
| CELE_ZK622.3 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | pmt-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:06 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 19 May 2006 11:42:44 | WBPerson2970 | Name_change | CGC_name | pmt-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pmt | ||||||||
| Allele (61) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (31) | |||||||||
| Paralog | WBGene00000765 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00008743 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015450 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00018811 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019198 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019675 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019961 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019963 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019968 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | pmt-1 encodes, by alternative splicing, four isoforms of an experimentally validated phosphoethanolamine N-methyltransferase required for phosphocholine biosynthesis and viability; PMT-1 lacks known mammalian orthologs, but has orthologs in parasitic nematodes, fish, amphibians, echinoderms, plants, alveolata, and bacteria; PMT-1 is distantly paralogous to PMT-2; PMT-1 catalyses the conversion of phosphoethanolamine to phospho-monomethylethanolamine (a precursor of phosphocholine) but does not proceed to further methylation steps, as do the multifunctional enzymes of plants or plasmodia; PMT-1 binds its substrates in random order, and is feedback-inhibited by phosphocholine; pmt-1(RNAi) animals fail to grow or develop, but can be rescued by phosphocholine precursors in their food media; given its phylogenetic and enzymatic specificity, coupled with its inviable RNAi phenotype, PMT-1 is a plausible target for nematicides. | Paper_evidence | WBPaper00027622 | |||||
| WBPaper00029127 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 24 Jul 2007 00:00:00 | ||||||||
| Automated_description | Enables phosphoethanolamine N-methyltransferase activity. Involved in multicellular organism reproduction; nematode larval development; and phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline. Predicted to be located in cytosol. Expressed in seam cell. Used to study lipid metabolism disorder. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:3146 | Homo sapiens | Paper_evidence | WBPaper00038215 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 Mar 2021 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000889 | ||||||||
| Molecular_info | Corresponding_CDS | ZK622.3a | |||||||
| ZK622.3b | |||||||||
| ZK622.3d | |||||||||
| Corresponding_CDS_history | ZK622.3a:wp94 | ||||||||
| ZK622.3c:wp245 | |||||||||
| Corresponding_transcript | ZK622.3c | ||||||||
| ZK622.3a.1 | |||||||||
| ZK622.3a.2 | |||||||||
| ZK622.3b.1 | |||||||||
| ZK622.3d.1 | |||||||||
| ZK622.3d.2 | |||||||||
| ZK622.3d.3 | |||||||||
| ZK622.3d.4 | |||||||||
| Other_sequence (60) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern | Expr9200 | ||||||||
| Expr1017664 | |||||||||
| Expr1040073 | |||||||||
| Expr1162979 | |||||||||
| Expr2014979 | |||||||||
| Expr2033214 | |||||||||
| Drives_construct | WBCnstr00009292 | ||||||||
| WBCnstr00013790 | |||||||||
| Antibody | WBAntibody00001280 | ||||||||
| Microarray_results (50) | |||||||||
| Expression_cluster (231) | |||||||||
| Interaction (55) | |||||||||
| Map_info | Map | II | Position | -1.81061 | Error | 0.004298 | |||
| Positive | Positive_clone | ZK622 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Picture | WBPicture0000013096 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
