cnep-1 encodes a putative serine/threonine phosphatase, orthologous to budding yeast Nem1p and human DULLARD; CNEP-1 is expressed in pharynx and intestine; CNEP-1 is distantly similar to FCP-1 and SCPL-1, -3, and -4; by homology, CNEP-1 is predicted to reside in the endoplasmic reticulum membrane in a complex with SPO-7 that functions to dephosphorylate the phosphatidic acid phosphatase LPIN-1 and thus regulate phospholipid metabolism; loss of cnep-1 activity via RNAi results in a twinned nuclei phenotype in which the embryonic blastomeres AB and P1 contain two nuclei; the twinned nuclei phenotype is also seen in embryos lacking spo-7 and lpin-1 activity.
Predicted to enable protein serine/threonine phosphatase activity. Involved in nuclear membrane reassembly and regulation of nuclear division. Located in nuclear envelope. Is an ortholog of human CTDNEP1 (CTD nuclear envelope phosphatase 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.