WormBase Tree Display for Gene: WBGene00018271
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| WBGene00018271 | SMap | S_parent | Sequence | F41C3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ctsa-1.1 | |||||||
| Sequence_name | F41C3.5 | ||||||||
| Molecular_name | F41C3.5 | ||||||||
| F41C3.5.1 | |||||||||
| CE02733 | |||||||||
| Other_name | CELE_F41C3.5 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | ctsa-1.1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 11 Dec 2018 16:50:34 | WBPerson1983 | Name_change | CGC_name | ctsa-1.1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ctsa | ||||||||
| Allele (32) | |||||||||
| Strain | WBStrain00002932 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00047869 | ||||||||
| 00047870 | |||||||||
| 00047871 | |||||||||
| 00047872 | |||||||||
| 00047873 | |||||||||
| 00123459 | |||||||||
| 00123460 | |||||||||
| Ortholog (57) | |||||||||
| Paralog | WBGene00007462 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00008741 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00012445 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00012530 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00017969 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019617 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00021503 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019605 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009058 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | F41C3.5 encodes a serine carboxypeptidase that is related to human cathepsin A (CTSA, OMIM:256540, mutations are associated with galactosialidosis: beta-galactosidase and alpha-neuraminidase deficiency); microarray experiments have shown that F41C3.5 mRNA levels are reduced in a lin-14 loss-of-function mutant background, suggesting that F41C3.5 expression is positively regulated by LIN-14; large-scale expression studies suggest that F41C3.5 is expressed in many tissues, including the pharynx, intestine, nervous system and hypodermis. | Paper_evidence | WBPaper00026952 | |||||
| WBPaper00031006 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Jan 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Expressed in gonad. Human ortholog(s) of this gene implicated in galactosialidosis. Is an ortholog of human CTSA (cathepsin A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3211 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9251) | ||||
| DOID:0080540 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9251) | ||||||
| Molecular_info | Corresponding_CDS | F41C3.5 | |||||||
| Corresponding_transcript | F41C3.5.1 | ||||||||
| Other_sequence (202) | |||||||||
| Associated_feature | WBsf644127 | ||||||||
| WBsf644128 | |||||||||
| WBsf987685 | |||||||||
| WBsf221167 | |||||||||
| WBsf221168 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00107706 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00089077 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066765 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00046959 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032077 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115159 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1843 | ||||||||
| Expr2017 | |||||||||
| Expr4164 | |||||||||
| Expr6023 | |||||||||
| Expr1020170 | |||||||||
| Expr1037870 | |||||||||
| Expr1150823 | |||||||||
| Expr2003576 | |||||||||
| Expr2021794 | |||||||||
| Drives_construct | WBCnstr00003444 | ||||||||
| WBCnstr00026650 | |||||||||
| Construct_product | WBCnstr00026650 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (239) | |||||||||
| Interaction (102) | |||||||||
| Map_info | Map | II | Position | -3.0949 | |||||
| Positive | Positive_clone | F41C3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00026952 | ||||||||
| WBPaper00027766 | |||||||||
| WBPaper00033118 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00057562 | |||||||||
| WBPaper00059755 | |||||||||
| WBPaper00061547 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
