WormBase Tree Display for Gene: WBGene00017699

WBGene00017699 SMap: S_parent: Sequence: F22D3
  Identity: Version: 2
    Name: CGC_name: flcn-1 Person_evidence: WBPerson15935
      Sequence_name: F22D3.2
      Molecular_name (21)
      Other_name: CELE_F22D3.2 Accession_evidence: NDB BX284602
      Public_name: flcn-1
    DB_info: Database: AceView gene 2H237
        WormQTL gene WBGene00017699
        WormFlux gene WBGene00017699
        OMIM disease 135150
          gene 607273
        NDB locus_tag CELE_F22D3.2
        Panther gene CAEEL|WormBase=WBGene00017699|UniProtKB=H2KY80
          family PTHR31441
        NCBI gene 174134
        RefSeq protein NM_001306549.4
            NM_001330952.3
            NM_001276732.2
            NM_001381469.1
            NM_001306551.3
            NM_001381470.1
            NM_001026937.5
        TrEMBL UniProtAcc S6FCY3
            S6EZM3
            K0M7B5
            J7S130
            S6F533
            Q5DX40
            S6FMZ4
        UniProt_GCRP UniProtAcc S6FMZ4
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:59 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 29 Jun 2012 17:03:10 WBPerson2970 Name_change: CGC_name: flcn-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: flcn
    Allele: WBVar00172974
      WBVar02145196
      WBVar00172975
      WBVar01934862
      WBVar00172976
      WBVar01499702
      WBVar01934863
      WBVar00317940
      WBVar00257633
      WBVar00238182
      WBVar02002802
      WBVar00238183
      WBVar02002803
      WBVar00238184
      WBVar01250339
      WBVar00262790
      WBVar01250350
      WBVar01559594
      WBVar01498435
      WBVar01250362
      WBVar00741115
      WBVar00741116
      WBVar02109781
      WBVar00741117
      WBVar01250373
      WBVar00741118
      WBVar00741119
      WBVar00741120
      WBVar01240909
      WBVar01240910
      WBVar00741121
      WBVar01240912
      WBVar00741122
      WBVar00741123
      WBVar01240915
      WBVar01250384
      WBVar00741124
      WBVar00741125
      WBVar00741126
      WBVar01240923
      WBVar00741127
      WBVar01492759
      WBVar00741128
      WBVar00741129
      WBVar00741130
      WBVar01993956
      WBVar00741131
      WBVar00104387
      WBVar00310966
      WBVar00741132
      WBVar00741133
      WBVar01250395
      WBVar00741134
      WBVar00741135
      WBVar00741136
      WBVar00741137
      WBVar00741138
      WBVar00741139
      WBVar00741140
      WBVar00741141
      WBVar00741142
      WBVar00741143
      WBVar00741144
      WBVar00092246
      WBVar00741145
      WBVar00741146
      WBVar00741147
      WBVar00741148
      WBVar00741149
      WBVar00306342
      WBVar01604105
      WBVar00741150
      WBVar00741151
      WBVar01604106
      WBVar00306343
      WBVar00741152
      WBVar00316261
      WBVar01250417
      WBVar01604107
      WBVar00741153
      WBVar00316262
      WBVar00741154
      WBVar00276389
      WBVar00741155
      WBVar00741156
      WBVar02145275
      WBVar00741157
      WBVar01783969
      WBVar00741158
      WBVar00741159
      WBVar00741160
      WBVar00741161
      WBVar00741162
      WBVar00741163
      WBVar00741164
      WBVar01916772
      WBVar00741165
      WBVar00741166
      WBVar00741167
      WBVar00741168
      WBVar00741169
      WBVar00741170
      WBVar00741171
      WBVar00741172
      WBVar00741173
      WBVar00741174
      WBVar00741175
      WBVar00741176
      WBVar00741177
      WBVar00741178
      WBVar00741179
      WBVar00741180
      WBVar00741181
      WBVar00741182
      WBVar01626650
      WBVar00741183
      WBVar01626651
      WBVar00741184
      WBVar02066989
      WBVar02100094
      WBVar00741185
      WBVar00741186
      WBVar00741187
      WBVar01943379
      WBVar00741188
      WBVar00369156
      WBVar01943380
      WBVar00369157
      WBVar00741189
      WBVar00741190
      WBVar00369158
      WBVar00741191
      WBVar00369159
      WBVar00369160
      WBVar00741192
      WBVar00741193
      WBVar00369161
      WBVar00741194
      WBVar00369162
      WBVar00369163
      WBVar00741195
      WBVar00741196
      WBVar00369164
      WBVar01685335
      WBVar00307666
      WBVar00234614
      WBVar00369165
      WBVar00741197
      WBVar00369166
      WBVar00741198
      WBVar01685336
      WBVar00369167
      WBVar00741199
      WBVar00741200
      WBVar00369168
      WBVar00369169
      WBVar00741201
      WBVar00741202
      WBVar00369170
      WBVar00369171
      WBVar00741203
      WBVar00369172
      WBVar00741204
      WBVar00741205
      WBVar00369173
      WBVar00369174
      WBVar00741206
      WBVar02012107
      WBVar00741207
      WBVar00369175
      WBVar02152291
      WBVar00741208
      WBVar00369176
      WBVar00741209
      WBVar00369177
      WBVar00551129
      WBVar00369178
      WBVar00741210
      WBVar00369179
      WBVar00741211
      WBVar00741212
      WBVar00319806
      WBVar00369180
      WBVar00741213
      WBVar00369181
      WBVar00741214
      WBVar00369182
      WBVar00741215
      WBVar00369183
      WBVar00369184
      WBVar00741216
      WBVar00369185
      WBVar00741217
      WBVar00369186
      WBVar00602333
      WBVar00741218
      WBVar00369187
      WBVar01438316
      WBVar01393728
      WBVar00741219
      WBVar01438317
      WBVar00369188
      WBVar00741220
      WBVar01393731
      WBVar00369189
      WBVar01438318
      WBVar01393732
      WBVar00741221
      WBVar01438320
      WBVar00369190
      WBVar01438321
      WBVar00369191
      WBVar00369192
      WBVar01438322
      WBVar00369193
      WBVar01438323
      WBVar00369194
      WBVar00369195
      WBVar00369196
      WBVar01538246
      WBVar01538247
      WBVar01405203
      WBVar01405205
      WBVar01374778
      WBVar01477604
      WBVar02130170
      WBVar00225269
      WBVar01374789
      WBVar00268773
      WBVar02130171
      WBVar00225271
      WBVar00225274
      WBVar01307292
      WBVar01374800
      WBVar01307298
      WBVar01374811
      WBVar01307300
      WBVar00172965
      WBVar01318840
      WBVar01374823
      WBVar00172966
      WBVar00172967
      WBVar00305170
      WBVar00172968
      WBVar00305171
      WBVar00172969
      WBVar00305172
      WBVar00172970
      WBVar00172971
      WBVar00305173
      WBVar00172972
      WBVar00172973
    Strain: WBStrain00031743
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (40)
    Structured_description: Concise_description: F22D3.2 encodes an ortholog of human folliculin (OMIM:607273, mutated inBirt-Hogg-Dube syndrome). Paper_evidence: WBPaper00028837
          Curator_confirmed: WBPerson567
          Date_last_updated: 11 Dec 2006 00:00:00
      Automated_description: Predicted to contribute to GTPase activator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of TORC1 signaling; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol. Expressed in excretory cell; nervous system; spermatheca; and vulva. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in several diseases, including Birt-Hogg-Dube syndrome; primary spontaneous pneumothorax; and renal cell carcinoma. Is an ortholog of human FLCN (folliculin). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0050676 Homo sapiens Paper_evidence: WBPaper00048631
          Accession_evidence: OMIM 135150
          Curator_confirmed: WBPerson324
          Date_last_updated: 03 Nov 2015 00:00:00
    Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27310)
      DOID:0080218 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27310)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27310)
      DOID:0050676 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27310)
  Models_disease_in_annotation: WBDOannot00000382
  Molecular_info: Corresponding_CDS: F22D3.2c
      F22D3.2d
      F22D3.2e
      F22D3.2f
      F22D3.2g
      F22D3.2i
      F22D3.2j
    Corresponding_CDS_history: F22D3.2:wp127
      F22D3.2a:wp206
      F22D3.2a:wp238
      F22D3.2a:wp274
      F22D3.2b:wp206
      F22D3.2b:wp238
      F22D3.2h:wp274
    Corresponding_transcript: F22D3.2c.1
      F22D3.2d.1
      F22D3.2e.1
      F22D3.2f.1
      F22D3.2g.1
      F22D3.2i.1
      F22D3.2j.1
    Other_sequence (21)
    Associated_feature (63)
  Experimental_info: RNAi_result: WBRNAi00013748 Inferred_automatically: RNAi_primary
      WBRNAi00045306 Inferred_automatically: RNAi_primary
      WBRNAi00013747 Inferred_automatically: RNAi_primary
      WBRNAi00031265 Inferred_automatically: RNAi_primary
      WBRNAi00092437 Inferred_automatically: RNAi_primary
      WBRNAi00092428 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr10985
      Expr13864
      Expr1017397
      Expr1037596
      Expr1149230
      Expr2011814
      Expr2030052
    Drives_construct: WBCnstr00017598
      WBCnstr00017614
      WBCnstr00027093
    Construct_product: WBCnstr00017614
      WBCnstr00027093
      WBCnstr00040219
    Regulate_expr_cluster: WBPaper00042236:flcn-1(ok975)_upregulated
      WBPaper00056471:flcn-1(ok975)_downregulated
      WBPaper00056471:flcn-1(ok975)_upregulated
    Antibody: WBAntibody00002522
    Microarray_results (41)
    Expression_cluster (164)
    Interaction: WBInteraction000402369
      WBInteraction000520210
      WBInteraction000520211
      WBInteraction000520212
      WBInteraction000520213
      WBInteraction000520218
      WBInteraction000521811
      WBInteraction000534849
  Map_info: Map: II Position: 0.145905
    Positive: Positive_clone: F22D3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00042236
    WBPaper00043118
    WBPaper00048129
    WBPaper00048631
    WBPaper00049821
    WBPaper00051847
    WBPaper00055071
    WBPaper00055090
    WBPaper00061202
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene