WormBase Tree Display for Gene: WBGene00017464

WBGene00017464 SMap: S_parent: Sequence: F14D12
  Identity: Version: 2
    Name: CGC_name: sulp-2 Person_evidence: WBPerson2233
      Sequence_name: F14D12.5
      Molecular_name: F14D12.5
        F14D12.5.1
        CE27963
      Other_name: CELE_F14D12.5 Accession_evidence: NDB BX284606
      Public_name: sulp-2
    DB_info: Database: AceView gene XG216
        WormQTL gene WBGene00017464
        WormFlux gene WBGene00017464
        NDB locus_tag CELE_F14D12.5
        Panther gene CAEEL|WormBase=WBGene00017464|UniProtKB=G5EDS5
          family PTHR11814
        NCBI gene 180828
        RefSeq protein NM_076543.7
        TrEMBL UniProtAcc G5EDS5
        UniProt_GCRP UniProtAcc G5EDS5
        OMIM gene 126650
            604943
            605646
            610130
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:58 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 19 Jan 2005 16:30:54 WBPerson2970 Name_change: CGC_name: sulp-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sulp
    Allele (50)
    Strain: WBStrain00032065
      WBStrain00032068
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (44)
    Paralog: WBGene00010788 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010789 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00012259 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00013963 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00016945 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00018283 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020914 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: sulp-2 encodes one of eight C. elegans members of the sulfate permease family of anion transporters; by homology, SULP-2 is predicted to function as an anion transporter that regulates cellular pH and volume via transmembrane movement of electrolytes and fluids and when expressed in Xenopus oocytes, SULP-2 does exhibit modest uptake of sulfate; a SULP-2::GFP fusion is expressed in the intestine and rectal gland cells, where it localizes to the basolateral membrane and in cephalic and deirid neurons, where it localizes to sensillar endings. Paper_evidence: WBPaper00025075
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 Sep 2006 00:00:00
      Automated_description: Enables sulfate transmembrane transporter activity. Predicted to be involved in inorganic anion transmembrane transport and organic anion transport. Located in basolateral plasma membrane and non-motile cilium. Expressed in dopaminergic neurons and intestine. Human ortholog(s) of this gene implicated in several diseases, including Pendred Syndrome; autosomal recessive nonsyndromic deafness (multiple); and calcium oxalate nephrolithiasis. Is an ortholog of several human genes including SLC26A1 (solute carrier family 26 member 1); SLC26A3 (solute carrier family 26 member 3); and SLC26A4 (solute carrier family 26 member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:12176 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8818)
      DOID:0060744 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8818)
      DOID:0060296 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3018)
      DOID:0110498 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8818)
      DOID:0110513 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9359)
      DOID:0080652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10993)
      DOID:13250 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3018)
  Molecular_info: Corresponding_CDS: F14D12.5
    Corresponding_transcript: F14D12.5.1
    Other_sequence: CJC12795_1
    Associated_feature: WBsf670538
      WBsf237387
  Experimental_info: RNAi_result: WBRNAi00000992 Inferred_automatically: RNAi_primary
      WBRNAi00030931 Inferred_automatically: RNAi_primary
      WBRNAi00013264 Inferred_automatically: RNAi_primary
      WBRNAi00044586 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3247
      Expr3259
      Expr1010356
      Expr1148543
      Expr2017113
      Expr2035249
    Drives_construct: WBCnstr00011250
      WBCnstr00011262
      WBCnstr00027278
    Construct_product: WBCnstr00011262
      WBCnstr00027278
    Microarray_results (18)
    Expression_cluster (152)
    Interaction (24)
  Map_info: Map: X Position: -4.46315 Error: 0.008938
    Positive: Positive_clone: F14D12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5231
    Pseudo_map_position
  Reference: WBPaper00025075
    WBPaper00035539
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene