Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00017089

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00017089SMapS_parentSequenceE01A2
IdentityVersion2
NameCGC_namepoml-2Person_evidenceWBPerson10017
WBPerson95
Sequence_nameE01A2.7
Molecular_nameE01A2.7
E01A2.7.1
CE24874
Other_nameCELE_E01A2.7Accession_evidenceNDBBX284601
Public_namepoml-2
DB_infoDatabaseAceViewgene1E712
WormQTLgeneWBGene00017089
WormFluxgeneWBGene00017089
NDBlocus_tagCELE_E01A2.7
PanthergeneCAEEL|WormBase=WBGene00017089|UniProtKB=Q966L1
familyPTHR11799
NCBIgene171999
RefSeqproteinNM_058905.5
TREEFAMTREEFAM_IDTF322436
TrEMBLUniProtAccQ966L1
UniProt_GCRPUniProtAccQ966L1
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:30:58WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
213 Apr 2012 16:55:20WBPerson2970Name_changeCGC_namepoml-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpoml
Allele (30)
StrainWBStrain00032254
RNASeq_FPKM (74)
GO_annotation00091003
00091004
00122569
Ortholog (57)
ParalogWBGene00003170Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00010775Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00077701Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00044697Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
Structured_descriptionConcise_descriptionThe E01A2.7 gene encodes one of five paraoxonase-like proteins; it is homologous to the human genes PARAOXONASE 1 gene (PON1, OMIM:168820) and PARAOXONASE 2 (OMIM:602447), which in some allelic forms are associated with susceptibility to coronary artery disease or to variations in fasting plasma glucose.Paper_evidenceWBPaper00005591
Curator_confirmedWBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable arylesterase activity and metal ion binding activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); eye disease (multiple); and hematologic cancer (multiple). Is an ortholog of human PON1 (paraoxonase 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (48)
Molecular_infoCorresponding_CDSE01A2.7
Corresponding_transcriptE01A2.7.1
Other_sequenceOden_isotig15033
CJC01469_1
Tcir_isotig22284
Oden_isotig15034
FK802982.1
ES413786.1
Associated_featureWBsf664125
WBsf219243
Experimental_infoRNAi_resultWBRNAi00043561Inferred_automaticallyRNAi_primary
WBRNAi00033607Inferred_automaticallyRNAi_primary
WBRNAi00023692Inferred_automaticallyRNAi_primary
WBRNAi00023396Inferred_automaticallyRNAi_primary
WBRNAi00023980Inferred_automaticallyRNAi_primary
WBRNAi00023180Inferred_automaticallyRNAi_primary
WBRNAi00003308Inferred_automaticallyRNAi_primary
Expr_patternExpr1013081
Expr1037347
Expr1147555
Expr2014997
Expr2033232
Drives_constructWBCnstr00027577
Construct_productWBCnstr00027577
Microarray_results (19)
Expression_clusterWBPaper00030922:glycosylated_protein
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:intestine_embryo_enriched
WBPaper00037950:pharyngeal-muscle_embryo_enriched
WBPaper00038168:lin-15B(n744)_downregulated
WBPaper00038237:age-1_upregulated_intestine_rescue
WBPaper00038237:age-1_upregulated_neuron_rescue
WBPaper00038237:age-1_upregulated_nontransgenic
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00044030:nhr-8(hd117)_downregulated
WBPaper00044316:CH3HgCl_7.5uM_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045390:ubc-9(RNAi)_upregulated
WBPaper00045521:Gender_Neutral
WBPaper00045934:wrn-1(gk99)_downregulated
WBPaper00046121:endoderm_unique
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048971:daf-16(mgDf50)_downregulated_L1
WBPaper00049134:hpk-1(pk1393)_downregulated
WBPaper00049732:blmp-1(tm548)_vs_N2_downregulated
WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00051558:aging_regulated
WBPaper00053318:Aging_downregulated_mRNA_N2
WBPaper00053318:mir-71(n4115)_downregulated_mRNA
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053810:sod-2(ok1030)_upregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055827:daf-2(e1370)_upregulated
WBPaper00056034:pals-25(jy9)_downregulated
WBPaper00056169:rrf-3(pk1426)_downregulated_L1
WBPaper00056169:rrf-3(pk1426)_downregulated_L3
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00057158:mdt-15(tm2182)_dependent_15C_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058711:skn-1(lax188)_downregulated
WBPaper00058948:PA14_upregulated
WBPaper00059117:B.subtilis_downregulated
WBPaper00059191:hsp-16.2p-LIN-29_upregulated
WBPaper00059604:fluvastatin_upregulated_dlk-1(km12)
WBPaper00059604:fluvastatin_upregulated_N2
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
WBPaper00059763:neuron_expressed
WBPaper00059895:wounding_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060661:hypoxia_downregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061106:endu-2(tm4977)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:Intestine
WBPaper00061341:28C_48h_downregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:gst-26-pho-1_10767
WBPaper00061530:nhr-49(e2144)_downregulated
WBPaper00061651:VA12_enriched
WBPaper00061699:daf-18(ok480)_downregulated
WBPaper00061853:osm-3(dh441)_downregulated_tunicamycin
WBPaper00061952:daf-18(nr2037)_downregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_downregulated_N2
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062446:nhr-8(hd117)_downregulated
WBPaper00062590:Aging_downregulated_hypodermis
WBPaper00062590:Aging_downregulated_neuron
WBPaper00062672:let-418(n3536)dcp-66(RNAi)_downregulated
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064107:lin-35(n745)_downregulated
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064532:pals-22(jy3)_downregulated
WBPaper00064632:daf-2(e1370)_upregulated_intestine
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065074:glna(-)_upregulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
WBPaper00065272:dhgd-1(tm6671)_downregulated
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:6_2
WBPaper00065841:6_3
WBPaper00065841:12_0
WBPaper00065841:68_1
WBPaper00065841:134_0
WBPaper00065841:136_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4489_group_6
WBPaper00025032:cluster_16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00028789:PA14_vs_OP50_downregulated_8hr
WBPaper00031832:slr-2_regulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00036286:Pattern_I
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00038231:Cry5B_2-fold_downregulated
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
WBPaper00040963:Q200_up
WBPaper00040963:TA300_up
WBPaper00041002:HQ_3d_0.2mM_Up
WBPaper00041174:environmental
WBPaper00041174:environmental_prime
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041906:I-3690_vs_OP50_3d
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00044091:Bpseudomallei_repressed_12h
WBPaper00045015:nhr-25(RNAi)_downregulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00047070:N2_UV_downregulated
WBPaper00047070:xpa-1_UV_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:N2_allantoin_upregulated
WBPaper00053236:daf-16(mgDF50)_regulated_Starved
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00057098:SiO2-nanoparticles_downregulated
InteractionWBInteraction000123689
WBInteraction000123690
Map_infoMapIPosition-1.69879
PositivePositive_cloneE01A2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00038491
WBPaper00055090
WBPaper00065080
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene