WormBase Tree Display for Gene: WBGene00010775
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| WBGene00010775 | SMap | S_parent | Sequence | K11E4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | poml-1 | Person_evidence | WBPerson10017 | |||||
| WBPerson95 | |||||||||
| Sequence_name | K11E4.3 | ||||||||
| Molecular_name | K11E4.3 | ||||||||
| K11E4.3.1 | |||||||||
| CE44204 | |||||||||
| Other_name | CELE_K11E4.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | poml-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 13 Apr 2012 16:55:20 | WBPerson2970 | Name_change | CGC_name | poml-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | poml | ||||||||
| Allele (81) | |||||||||
| Strain | WBStrain00032454 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00071586 | ||||||||
| 00071587 | |||||||||
| 00071588 | |||||||||
| 00071589 | |||||||||
| 00071590 | |||||||||
| 00118109 | |||||||||
| Ortholog (29) | |||||||||
| Paralog | WBGene00003170 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00077701 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00017089 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00044697 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | poml-1 is homologous to the human Paraoxonase family of genes (PON1, PON2, PON3), which are arylesterases that mainly hydrolyze paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion; the PON genes also hydrolyze the toxic metabolites of a variety of organophosphorus insecticides. | Paper_evidence | WBPaper00005591 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 May 2013 00:00:00 | ||||||||
| Automated_description | Enables protein folding chaperone. Involved in protein maturation by protein folding. Located in rough endoplasmic reticulum. Expressed in neurons. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); eye disease (multiple); and hematologic cancer (multiple). Is an ortholog of human PON1 (paraoxonase 1); PON2 (paraoxonase 2); and PON3 (paraoxonase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1289 | Homo sapiens | Paper_evidence | WBPaper00049330 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 13 Mar 2023 00:00:00 | ||||||||
| Potential_model (51) | |||||||||
| Disease_relevance | Human pon genes, PON1, PON2 and PON3 are arylesterases that are involved in the detoxification of the metabolites of organophosphorus insecticides; mutations in PON1 have been implicated in coronary artery disease and the microvascular complications of diabetes. | Homo sapiens | Accession_evidence | OMIM | 612633 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 May 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000170 | ||||||||
| Molecular_info | Corresponding_CDS | K11E4.3 | |||||||
| Corresponding_CDS_history | K11E4.3:wp208 | ||||||||
| Corresponding_transcript | K11E4.3.1 | ||||||||
| Associated_feature | WBsf654539 | ||||||||
| WBsf671212 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00017015 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00050604 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9888 | ||||||||
| Expr12564 | |||||||||
| Expr12767 | |||||||||
| Expr1017377 | |||||||||
| Expr1154312 | |||||||||
| Expr2014996 | |||||||||
| Expr2033231 | |||||||||
| Drives_construct | WBCnstr00009826 | ||||||||
| WBCnstr00014378 | |||||||||
| WBCnstr00021619 | |||||||||
| WBCnstr00022647 | |||||||||
| WBCnstr00022762 | |||||||||
| WBCnstr00031156 | |||||||||
| Construct_product | WBCnstr00009826 | ||||||||
| WBCnstr00014378 | |||||||||
| WBCnstr00022647 | |||||||||
| WBCnstr00022762 | |||||||||
| WBCnstr00031156 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (64) | |||||||||
| Interaction (25) | |||||||||
| Map_info | Map | X | Position | 14.46 | |||||
| Positive | Positive_clone | K11E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00034024 | ||||||||
| WBPaper00034065 | |||||||||
| WBPaper00039337 | |||||||||
| WBPaper00047789 | |||||||||
| WBPaper00048712 | |||||||||
| WBPaper00049330 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
