WormBase Tree Display for Gene: WBGene00017089

WBGene00017089 SMap: S_parent: Sequence: E01A2
  Identity: Version: 2
    Name: CGC_name: poml-2 Person_evidence: WBPerson10017
            WBPerson95
      Sequence_name: E01A2.7
      Molecular_name: E01A2.7
        E01A2.7.1
        CE24874
      Other_name: CELE_E01A2.7 Accession_evidence: NDB BX284601
      Public_name: poml-2
    DB_info: Database: AceView gene 1E712
        WormQTL gene WBGene00017089
        WormFlux gene WBGene00017089
        NDB locus_tag CELE_E01A2.7
        Panther gene CAEEL|WormBase=WBGene00017089|UniProtKB=Q966L1
          family PTHR11799
        NCBI gene 171999
        RefSeq protein NM_058905.5
        TREEFAM TREEFAM_ID TF322436
        TrEMBL UniProtAcc Q966L1
        UniProt_GCRP UniProtAcc Q966L1
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:58 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 13 Apr 2012 16:55:20 WBPerson2970 Name_change: CGC_name: poml-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: poml
    Allele (30)
    Strain: WBStrain00032254
    RNASeq_FPKM (74)
    GO_annotation: 00091003
      00091004
      00122569
    Ortholog (57)
    Paralog: WBGene00003170 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010775 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00077701 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00044697 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: The E01A2.7 gene encodes one of five paraoxonase-like proteins; it is homologous to the human genes PARAOXONASE 1 gene (PON1, OMIM:168820) and PARAOXONASE 2 (OMIM:602447), which in some allelic forms are associated with susceptibility to coronary artery disease or to variations in fasting plasma glucose. Paper_evidence: WBPaper00005591
          Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable arylesterase activity and metal ion binding activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); eye disease (multiple); and hematologic cancer (multiple). Is an ortholog of human PON1 (paraoxonase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (48)
  Molecular_info: Corresponding_CDS: E01A2.7
    Corresponding_transcript: E01A2.7.1
    Other_sequence: Oden_isotig15033
      CJC01469_1
      Tcir_isotig22284
      Oden_isotig15034
      FK802982.1
      ES413786.1
    Associated_feature: WBsf664125
      WBsf219243
  Experimental_info: RNAi_result: WBRNAi00043561 Inferred_automatically: RNAi_primary
      WBRNAi00033607 Inferred_automatically: RNAi_primary
      WBRNAi00023692 Inferred_automatically: RNAi_primary
      WBRNAi00023396 Inferred_automatically: RNAi_primary
      WBRNAi00023980 Inferred_automatically: RNAi_primary
      WBRNAi00023180 Inferred_automatically: RNAi_primary
      WBRNAi00003308 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1013081
      Expr1037347
      Expr1147555
      Expr2014997
      Expr2033232
    Drives_construct: WBCnstr00027577
    Construct_product: WBCnstr00027577
    Microarray_results (19)
    Expression_cluster (155)
    Interaction: WBInteraction000123689
      WBInteraction000123690
  Map_info: Map: I Position: -1.69879
    Positive: Positive_clone: E01A2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00065080
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene