WormBase Tree Display for Gene: WBGene00016655

WBGene00016655 SMap: S_parent: Sequence: C44E4
  Identity: Version: 2
    Name: CGC_name: acbp-1 Person_evidence: WBPerson344
      Sequence_name: C44E4.6
      Molecular_name: C44E4.6
        C44E4.6.1
        CE08720
        C44E4.6.2
      Other_name: CELE_C44E4.6 Accession_evidence: NDB BX284601
      Public_name: acbp-1
    DB_info: Database: AceView gene 1F204
        WormQTL gene WBGene00016655
        WormFlux gene WBGene00016655
        NDB locus_tag CELE_C44E4.6
        Panther gene CAEEL|WormBase=WBGene00016655|UniProtKB=O01805
          family PTHR23310
        NCBI gene 172071
        RefSeq protein NM_059011.8
        SwissProt UniProtAcc O01805
        TREEFAM TREEFAM_ID TF315078
        UniProt_GCRP UniProtAcc O01805
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 01 Apr 2005 11:05:24 WBPerson2970 Name_change: CGC_name: acbp-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acbp
    Allele (28)
    Strain: WBStrain00033090
    RNASeq_FPKM (74)
    GO_annotation: 00025731
      00025732
      00025733
      00025734
      00025735
      00122228
    Contained_in_operon: CEOP1196
    Ortholog (36)
    Paralog: WBGene00001153 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007680 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009818 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012457 Caenorhabditis elegans From_analysis: Panther
      WBGene00044603 Caenorhabditis elegans From_analysis: Panther
      WBGene00018949 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: acbp-1 encodes a highly conserved protein containing a functional acyl-CoA-binding binding domain orthologous to human DBI (Diazepam Binding inhibitor) (OMIM: 125950) required for protein stability and ligand binding; acyl-CoA proteins are required for lipid droplet morphology and lipid storage function; acbp-1 mutants have reduced triglycerides, aberrant lipid droplet morphology and number in the intestine; mutants contain approximately 70% fewer but 3.8 times enlarged than that of the average lipid droplet; loss of ACBP-1 results in increased lipid chain unsaturation by 1.25 times; disruption of ACBP-1 function significantly reduces worm life span from 14 to 9 days; ACBP-1::GFP is predominantly expressed in intestine of L4 larvae. Paper_evidence: WBPaper00038378
          Curator_confirmed: WBPerson12884
            WBPerson1843
          Date_last_updated: 16 May 2011 00:00:00
      Automated_description: Predicted to enable long-chain fatty acyl-CoA binding activity. Involved in determination of adult lifespan and lipid storage. Is an ortholog of human DBI (diazepam binding inhibitor, acyl-CoA binding protein). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C44E4.6
    Corresponding_transcript: C44E4.6.1
      C44E4.6.2
    Other_sequence: GR14873
      Tcir_isotig20858
      Tcol_isotig21312
      MH10887
      JI472356.1
      ASC17443_1
      Dviv_isotig15304
      Tcir_isotig10732
      ES408833.1
      Acan_isotig12435
    Associated_feature: WBsf649109
      WBsf649110
      WBsf664159
      WBsf219293
      WBsf219294
  Experimental_info: RNAi_result: WBRNAi00023965 Inferred_automatically: RNAi_primary
      WBRNAi00023089 Inferred_automatically: RNAi_primary
      WBRNAi00023677 Inferred_automatically: RNAi_primary
      WBRNAi00042488 Inferred_automatically: RNAi_primary
      WBRNAi00076215 Inferred_automatically: RNAi_primary
      WBRNAi00023165 Inferred_automatically: RNAi_primary
      WBRNAi00029810 Inferred_automatically: RNAi_primary
      WBRNAi00001450 Inferred_automatically: RNAi_primary
      WBRNAi00003156 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr13616
      Expr13619
      Expr1016939
      Expr1037161
      Expr1146474
      Expr2009114
      Expr2027351
    Drives_construct: WBCnstr00039882
    Construct_product: WBCnstr00039882
    Microarray_results (20)
    Expression_cluster (131)
    Interaction (40)
  Map_info: Map: I Position: -1.03673 Error: 0.000586
    Positive: Positive_clone: C44E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027468
    WBPaper00033353
    WBPaper00038378
    WBPaper00038491
    WBPaper00039062
    WBPaper00049828
    WBPaper00055090
    WBPaper00063976
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene