acbp-1 encodes a highly conserved protein containing a functional acyl-CoA-binding binding domain orthologous to human DBI (Diazepam Binding inhibitor) (OMIM: 125950) required for protein stability and ligand binding; acyl-CoA proteins are required for lipid droplet morphology and lipid storage function; acbp-1 mutants have reduced triglycerides, aberrant lipid droplet morphology and number in the intestine; mutants contain approximately 70% fewer but 3.8 times enlarged than that of the average lipid droplet; loss of ACBP-1 results in increased lipid chain unsaturation by 1.25 times; disruption of ACBP-1 function significantly reduces worm life span from 14 to 9 days; ACBP-1::GFP is predominantly expressed in intestine of L4 larvae.
Predicted to enable long-chain fatty acyl-CoA binding activity. Involved in determination of adult lifespan and lipid storage. Is an ortholog of human DBI (diazepam binding inhibitor, acyl-CoA binding protein).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.